Reference on EC 2.6.1.13 - ornithine aminotransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Strecker, H.J.
Purification and properties of rat liver ornithine DELTA-transaminase
J. Biol. Chem.
240
1225-1230
1965
Rattus norvegicus
Peraino, C.; Bunville, L.G.; Tahmisian, T.N.
Chemical, physical, and morphological properties of ornithine aminotransferase from rat liver
J. Biol. Chem.
244
2241-2249
1969
Rattus norvegicus
Kanda, M.; Hori, K.; Kurotsu, T.; Saito, Y.
Purification and properties of ornithine and N-acetylornithine aminotransferases from gramicidin S-producing Bacillus brevis
Enzymes Depend. Pyridoxal Phosphate Other Carbonyl Compd. Cofactors, Proc. Int. Symp. Vitamin B6 Carbonyl Catal. , Meeting Date 1990 (Fukui, T. , ed. ), Pergamon, Oxford
8
241-243
1991
Brevibacillus brevis
-
Sharma, V.; Katiyar, J.C.; Ghatak, S.; Shukla, O.P.
Ornithine aminotransferase of hookworm parasites
Indian J. Parasitol.
12
237-242
1988
Ancylostoma ceylanicum, Nippostrongylus brasiliensis
-
Park, K.S.
Characterization of bovine liver ornithine aminotransferase
Han'guk Saenghwa Hak Hoe Chi
18
351-360
1985
Bos taurus
-
Kim, G.S.; Park, J.O.; Park, K.S.
Studies on the ornithine aminotransferase from chicken liver
Han'guk Saenghwa Hak Hoe Chi
18
109-115
1985
Gallus gallus
-
Shiono, T.; Hayasaka, S.; Mizuno, K.
Partial purification and certain properties of ornithine ketoacid aminotransferases in the ciliary body and iris and the retinal pigment epithelium of the bovine eye
Exp. Eye Res.
32
475-490
1981
Bos taurus
Yasuda, M.; Toyama, S.; Yonaha, K.; Soda, K.
Purification and crystallization of L-ornithine:ALPHA-ketoglutarate DELTA-aminotransferase from Corynebacterium sepedonicum
Bull. Inst. Chem. Res.
58
366-370
1980
Clavibacter michiganensis subsp. sepedonicus
-
Goldberg, M.; Flescher, E.; Gold, D.; Lengy, J.
Ornithine-DELTA-transaminase from the liver fluke, Fasciola hepatica and the blood fluke, Schistosoma mansoni: a comparative study
Comp. Biochem. Physiol. B
65
605-613
1980
Fasciola hepatica, Schistosoma mansoni
-
Goldberg, M.; Flescher, E.; Lengy, J.
Schistosoma mansoni: partial purification and properties of ornithine-delta-transaminase
Exp. Parasitol.
47
333-341
1979
Schistosoma mansoni
Lu, T.S.; Mazelis, M.
L-ornithine 2-oxoacid aminotransferase from squash (Curcubita pepo) cotyledons. Purification and properties
Plant Physiol.
55
502-506
1975
Cucurbita pepo
Peraino, C.
Functional properties of ornithine-ketoacid aminotransferase from rat liver
Biochim. Biophys. Acta
289
117-127
1972
Rattus norvegicus
Stevens, L.; Heaton, A.
Induction, partial purification and properties of ornithine transaminase from Aspergillus nidulans
Biochem. Soc. Trans.
1
749-751
1973
Aspergillus nidulans
-
Yasuda, M.; Misono, H.; Soda, K.; Yonaha, K.; Toyama, S.
Purification and crystallization of L-ornithine:alpha-ketoglutarate delta-aminotransferase from Bacillus sphaericus
FEBS Lett.
105
209-212
1979
Lysinibacillus sphaericus
Yasuda, M.; Toyama, S.; Rando, R.R.; Esaki, N.; Tanizawa, K.; Soda, K.
Irreversible inactivation of L-ornithine: ALPHA-ketoglutarate DELTA-aminotransferase by gabaculine
Agric. Biol. Chem.
44
3005-3006
1980
Lysinibacillus sphaericus
-
Hervieu, F.; Le Dily, F.; Le Saos, J.; Billard, J.P.; Huault, C.
Inhibition of plant ornithine aminotransferase by gabaculine and 4-amino-5-hexynoic acid
Phytochemistry
34
1231-1234
1993
Raphanus sativus
-
Daune, G.; Gerhart, F.; Seiler, N.
5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase
Biochem. J.
253
481-488
1988
Mus musculus, Rattus norvegicus
Matsuzawa, T.
Characteristics of the inhibition of ornithine-delta-aminotransferase by branched-chain amino acids
J. Biochem.
75
601-609
1974
Rattus norvegicus
Marcovic-Housley, Z.; Kania, M.; Lustig, A.; Vincent, M.G.; Jansonius, J.N.; John, R.A.
Quaternary structure of ornithine aminotransferase in solution and preliminary crystallographic data
Eur. J. Biochem.
162
345-350
1987
Rattus norvegicus
Boernke, W.E.; Stevens, F.J.; Peraino, C.
Effects of self-association of ornithine aminotransferase on its physicochemical characteristics
Biochemistry
20
115-121
1981
Rattus norvegicus
Matsuzawa, T.; Sugimoto, N.; Sobue, M.; Ishiguro, I.
Ornithine oxoacid aminotransferase found in AH 130 ascites hepatoma cells
Biochim. Biophys. Acta
714
356-360
1982
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Williams, J.A.; Bridge, G.; Fowler, L.J.; John, R.A.
The reaction of ornithine aminotransferase with ornithine
Biochem. J.
201
221-225
1982
Rattus norvegicus
Rosenthal, G.A.; Dahlman, D.L.
Interaction of L-canaline with ornithine aminotransferase of the tobacco hornworm, Manduca sexta (Sphingidae)
J. Biol. Chem.
265
868-873
1990
Manduca sexta
Yasuda, M.; Tanizawa, K.; Misono, H.; Toyama, S.; Soda, K.
Properties of crystalline L-ornithine: alpha-ketoglutarate delta-aminotransferase from Bacillus sphaericus
J. Bacteriol.
148
43-50
1981
Lysinibacillus sphaericus, Erwinia aroidea, Staphylococcus aureus, Lysinibacillus sphaericus IFO3525
Ohura, T.; Kominami, E.; Tada, K.; Katunuma, N.
Crystallization and properties of human liver ornithine aminotransferase
J. Biochem.
92
1785-1792
1982
Homo sapiens, Rattus norvegicus
Kalita, C.; Kerman, J.D.; Strecker, H.J.
Preparation and properties of ornithine-oxo-acid aminotransferase of rat kidney. Comparison with the liver enzyme
Biochim. Biophys. Acta
429
780-797
1976
Rattus norvegicus
Burcham, J.M.; Giometti, C.S.; Tollaksen, S.L.; Peraino, C.
Comparison of rat and mouse ornithine aminotransferase with respect to molecular properties and regulation of synthesis
Arch. Biochem. Biophys.
262
501-507
1988
Mus musculus, Rattus norvegicus
Kito, K.; Sanada, Y.; Katunuma, N.
Mode of inhibition of ornithine aminotransferase by L-canaline
J. Biochem.
83
201-206
1978
Rattus norvegicus
Cooper, A.J.L.
Glutamate-ornithine transaminases
Methods Enzymol.
113
76-79
1985
Neurospora crassa, Rattus norvegicus
Dekaney, C.M.; Wu, G.; Jaeger, L.A.
Ornithine aminotransferase messenger RNA expression and enzymatic activity in fetal porcine intestine
Pediatr. Res.
50
104-109
2001
Sus scrofa
Gafan, C.; Wilson, J.; Berger, L.C.; Berger, B.J.
Characterization of the ornithine aminotransferase from Plasmodium falciparum
Mol. Biochem. Parasitol.
118
1-10
2001
Plasmodium falciparum
Heinanen, K.; Nanto-Salonen, K.; Leino, L.; Pulkki, K.; Heinonen, O.; Valle, D.; Simell, O.
Gyrate atrophy of the choroid and retina: lymphocyte ornithine-d-aminotransferase activity in different mutations and carriers
Pediatr. Res.
44
381-385
1998
Homo sapiens
Jhee, K.H.; Yoshimura, T.; Esaki, N.; Yonaha, K.; Soda, K.
Thermostable ornithine aminotransferase from Bacillus sp. YM-2: purification and characterization
J. Biochem.
118
101-108
1995
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) YM-2
Levillain, O.; Diaz, J.J.; Reymond, I.; Soulet, D.
Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase
Pflugers Arch.
440
761-769
2000
Mus musculus
Lim, S.N.; Rho, H.W.; Park, J.W.; Jhee, E.C.; Kim, J.S.; Kim, H.R.
A variant of ornithine aminotransferase from mouse small intestine
Exp. Mol. Med.
30
131-135
1998
Mus musculus
Madan, S.; Nainawatee, H.S.
Properties of partially purified leaf ornithine aminotransferase of Brassica juncea under salt stress
Acta Physiol. Plant.
22
444-450
2000
Brassica juncea
-
Roosens, N.H.; Bitar, F.A.; Loenders, K.; Angenon, G.; Jacobs, M.
Overexpression of ornithine-delta-aminotransferase increases proline biosynthesis and confers osmotolerance in transgenic plants
Mol. Breed.
9
73-80
2002
Arabidopsis thaliana
Roosens, N.H.C.J.; Thu, T.T.; Iskandar, H.M.; Jacobs, M.
Isolation of the ornithine-d-aminotransferase cDNA and effect of salt stress on its expression in Arabidopsis thaliana
Plant Physiol.
117
263-271
1998
Arabidopsis thaliana
Roschinger, W.; Endres, W.; Shin, Y.S.
Characteristics of L-ornithine: 2-oxoacid aminotransferase and potential prenatal diagnosis of gyrate atrophy of the choroid and retina by first trimester chorionic villus sampling
Clin. Chim. Acta
296
91-100
2000
Homo sapiens, Rattus norvegicus
Seiler, N.
Ornithine aminotransferase, a potential target for the treatment of hyperammonemias
Curr. Drug Targets
1
119-153
2000
Homo sapiens, Rattus norvegicus
Shah, S.A.; Shen, B.W.; Brunger, A.T.
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition
Structure
5
1067-1075
1997
Homo sapiens
Shen, B.W.; Hennig, M.; Hohenester, E.; Jansonius, J.N.; Schirmer, T.
Crystal structure of human recombinant ornithine aminotransferase
J. Mol. Biol.
277
81-102
1998
Homo sapiens
Storici, P.; Capitani, G.; Muller, R.; Schirmer, T.; Jansonius, J.N.
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine
J. Mol. Biol.
285
297-309
1999
Homo sapiens (P04181), Homo sapiens
Yang, C.W.; Kao, C.H.
Importance of ornithine-delta-aminotransferase to proline accumulation caused by water stress in detached rice leaves
Plant Growth Regul.
27
189-192
1999
Oryza sativa
-
Levillain, O.; Hus-Citharel, A.; Garvi, S.; Peyrol, S.; Reymond, I.; Mutin, M.; Morel, F.
Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II
Am. J. Physiol. Renal. Physiol.
286
F727-738
2004
Rattus norvegicus (P04182)
Levillain, O.; Diaz, J.J.; Blanchard, O.; Dechaud, H.
Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney
Endocrinology
146
950-959
2005
Mus musculus (P29758), Mus musculus
Wu, L.; Fan, Z.; Guo, L.; Li, Y.; Chen, Z.L.; Qu, L.J.
Over-expression of the bacterial nhaA gene in rice enhances salt and drought tolerance
Plant Sci.
168
297-302
2005
Arabidopsis thaliana
Ohkubo, Y.; Ueta, A.; Ito, T.; Sumi, S.; Yamada, M.; Ozawa, K.; Togari, H.
Vitamin B6-responsive ornithine aminotransferase deficiency with a novel mutation G237D
Tohoku J. Exp. Med.
205
335-342
2005
Homo sapiens
Levillain, O.; Ventura, G.; Dechaud, H.; Hobeika, M.; Meseguer, A.; Moinard, C.; Cynober, L.
Sex-differential expression of ornithine aminotransferase in the mouse kidney
Am. J. Physiol. Renal Physiol.
292
F1016-F1027
2007
Mus musculus (P29758), Mus musculus
Markova, M.; Peneff, C.; Hewlins, M.J.; Schirmer, T.; John, R.A.
Determinants of substrate specificity in omega-aminotransferases
J. Biol. Chem.
280
36409-36416
2005
Homo sapiens (P04181)
Wang, G.; Shang, L.; Burgett, A.W.; Harran, P.G.; Wang, X.
Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division
Proc. Natl. Acad. Sci. USA
104
2068-2073
2007
Homo sapiens, Xenopus sp.
Funck, D.; Stadelhofer, B.; Koch, W.
Ornithine-delta-aminotransferase is essential for arginine catabolism but not for proline biosynthesis
BMC Plant Biol.
8
40
2008
Arabidopsis thaliana
Ventura, G.; De Bandt, J.P.; Segaud, F.; Perret, C.; Robic, D.; Levillain, O.; Le Plenier, S.; Godard, C.; Cynober, L.; Moinard, C.
Overexpression of ornithine aminotransferase: consequences on amino acid homeostasis
Br. J. Nutr.
101
843-851
2009
Homo sapiens, Mus musculus
Sekhar, P.N.; Amrutha, R.N.; Sangam, S.; Verma, D.P.; Kishor, P.B.
Biochemical characterization, homology modeling and docking studies of ornithine delta-aminotransferase - an important enzyme in proline biosynthesis of plants
J. Mol. Graph. Model.
26
709-719
2007
Vigna aconitifolia (P31893), Vigna aconitifolia
Dekaney, C.M.; Wu, G.; Yin, Y.L.; Jaeger, L.A.
Regulation of ornithine aminotransferase gene expression and activity by all-transretinoic acid in Caco-2 intestinal epithelial cells
J. Nutr. Biochem.
19
674-681
2008
Homo sapiens
Wagemaker, M.J.; Eastwood, D.C.; Welagen, J.; van der Drift, C.; Jetten, M.S.; Burton, K.; Van Griensven, L.J.; Op den Camp, H.J.
The role of ornithine aminotransferase in fruiting body formation of the mushroom Agaricus bisporus
Mycol. Res.
111
909-918
2007
Agaricus bisporus (Q2Z0F8), Agaricus bisporus
Canas, R.A.; Villalobos, D.P.; Diaz-Moreno, S.M.; Canovas, F.M.; Canton, F.R.
Molecular and functional analyses support a role of Ornithine-delta-aminotransferase in the provision of glutamate for glutamine biosynthesis during pine germination
Plant Physiol.
148
77-88
2008
Pinus sylvestris (Q1RPP3), Pinus sylvestris
Ravikumar, H.; Devaraju, K.; Shetty, K.
Effect of pH on spectral characteristics of P5C-ninhydrin derivative: Application in the assay of ornithine amino transferase activity from tissue lysate
Indian J. Clin. Biochem.
23
117-122
2008
Homo sapiens
Ravi Kumar, H.; Ananda, S.; Devaraju, K.; Prakash, B.; Sampath Kumar, S.; Suresh Babu, S.; Ramachandraswamy, N.; Puttaraju, H.
A sensitive assay for ornithine amino transferase in rat brain mitochondria by ninhydrin method
Indian J. Clin. Biochem.
24
275-279
2009
Rattus norvegicus
Fonknechten, N.; Perret, A.; Perchat, N.; Tricot, S.; Lechaplais, C.; Vallenet, D.; Vergne, C.; Zaparucha, A.; Le Paslier, D.; Weissenbach, J.; Salanoubat, M.
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine
J. Bacteriol.
191
3162-3167
2009
Acetoanaerobium sticklandii
Stranska, J.; Kopecny, D.; Tylichova, M.; Snegaroff, J.; Sebela, M.
Ornithine delta-aminotransferase: An enzyme implicated in salt tolerance in higher plants
Plant Signal. Behav.
3
929-935
2008
Cucurbita pepo, Homo sapiens, Nicotiana plumbaginifolia, Oryza sativa, Pisum sativum (B1A0U3), Vigna aconitifolia (P31893), Arabidopsis thaliana (Q9FNK4)
Ventura, G.; Moinard, C.; Segaud, F.; Le Plenier, S.; Cynober, L.; De Bandt, J.P.
Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase
Amino Acids
39
1417-1426
2010
Homo sapiens
Stranska, J.; Tylichova, M.; Kopecny, D.; Snegaroff, J.; Sebela, M.
Biochemical characterization of pea ornithine-delta-aminotransferase: substrate specificity and inhibition by di- and polyamines
Biochimie
92
940-948
2010
Pisum sativum
Jortzik, E.; Fritz-Wolf, K.; Sturm, N.; Hipp, M.; Rahlfs, S.; Becker, K.
Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase
J. Mol. Biol.
402
445-459
2010
Plasmodium falciparum (Q6LFH8)
da Rocha, I.M.; Vitorello, V.A.; Silva, J.S.; Ferreira-Silva, S.L.; Viegas, R.A.; Silva, E.N.; Silveira, J.A.
Exogenous ornithine is an effective precursor and the ?-ornithine amino transferase pathway contributes to proline accumulation under high N recycling in salt-stressed cashew leaves
J. Plant Physiol.
169
41-49
2012
Anacardium occidentale
Senthil-Kumar, M.; Mysore, K.S.
Ornithine-delta-aminotransferase and proline dehydrogenase genes play a role in non-host disease resistance by regulating pyrroline-5-carboxylate metabolism-induced hypersensitive response
Plant Cell Environ.
35
1329-1343
2012
Arabidopsis thaliana, Nicotiana benthamiana
Juncosa, J.I.; Lee, H.; Silverman, R.B.
Two continuous coupled assays for ornithine-delta-aminotransferase
Anal. Biochem.
440
145-149
2013
Homo sapiens (P04181)
da Silva, R.; Levillain, O.; Brosnan, J.T.; Araneda, S.; Brosnan, M.E.
The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes
Can. J. Physiol. Pharmacol.
91
362-368
2013
Rattus norvegicus (P04182)
Peng, Y.; Cooper, S.K.; Li, Y.; Mei, J.M.; Qiu, S.; Borchert, G.L.; Donald, S.P.; Kung, H.F.; Phang, J.M.
Ornithine-delta-aminotransferase inhibits neurogenesis during Xenopus embryonic development
Invest. Ophthalmol. Vis. Sci.
56
2486-2497
2015
Xenopus laevis (Q98TS5)
Hampel, A.; Huber, C.; Geffers, R.; Spona-Friedl, M.; Eisenreich, W.; Bange, F.C.
Mycobacterium tuberculosis is a natural ornithine aminotransferase (rocD) mutant and depends on Rv2323c for growth on arginine
PLoS ONE
10
e0136914
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Hao, N.; Mu, J.; Hu, N.; Xu, S.; Shen, P.; Yan, M.; Li, Y.; Xu, L.
Implication of ornithine acetyltransferase activity on L-ornithine production in Corynebacterium glutamicum
Biotechnol. Appl. Biochem.
63
15-21
2016
Corynebacterium glutamicum, Corynebacterium glutamicum 1006
Astegno, A.; Maresi, E.; Bertoldi, M.; La Verde, V.; Paiardini, A.; Dominici, P.
Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii
Biochem. J.
474
939-955
2017
Toxoplasma gondii (S8EY38), Toxoplasma gondii, Toxoplasma gondii ATCC 50611 (S8EY38), Toxoplasma gondii ME49 (S8EY38)
Ginguay, A.; Cynober, L.; Curis, E.; Nicolis, I.
Ornithine aminotransferase, an important glutamate-metabolizing enzyme at the crossroads of multiple metabolic pathways
Biology
6
18
2017
Bos taurus (Q3ZCF5), Geukensia demissa, Homo sapiens (P04181), Mus musculus (P29758), Oryctolagus cuniculus (A0A5F9CII4), Pisum sativum (B1A0U3), Plasmodium falciparum (Q6LFH8), Rattus norvegicus (P04182), Salmo trutta (A0A674DA32), Vigna aconitifolia (P31893)
Anwar, A.; She, M.; Wang, K.; Ye, X.
Cloning and molecular characterization of Triticum aestivum ornithine amino transferase (TaOAT) encoding genes
BMC Plant Biol.
20
187
2020
Triticum aestivum (A0A3B6KM96), Triticum aestivum (A0A3B6LSQ4), Triticum aestivum (A0A3B6MXE9), Triticum aestivum
Montioli, R.; Paiardini, A.; Giardina, G.; Zanzoni, S.; Cutruzzola, F.; Cellini, B.; Borri Voltattorni, C.
R180T variant of delta-ornithine aminotransferase associated with gyrate atrophy biochemical, computational, X-ray and NMR studies provide insight into its catalytic features
FEBS J.
286
2787-2798
2019
Homo sapiens (P04181)
Zhu, W.; Doubleday, P.F.; Catlin, D.S.; Weerawarna, P.M.; Butrin, A.; Shen, S.; Wawrzak, Z.; Kelleher, N.L.; Liu, D.; Silverman, R.B.
A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of gamma-aminobutyric Acid
J. Am. Chem. Soc.
142
4892-4903
2020
Homo sapiens (P04181), Homo sapiens
Liu, Y.; Wu, L.; Li, K.; Liu, F.; Wang, L.; Zhang, D.; Zhou, J.; Ma, X.; Wang, S.; Yang, S.
Ornithine aminotransferase promoted the proliferation and metastasis of non-small cell lung cancer via upregulation of miR-21
J. Cell. Physiol.
234
12828-12838
2019
Homo sapiens (P04181), Homo sapiens
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