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Information on EC 2.5.1.48 - cystathionine gamma-synthase

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IUBMB Comments
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
AtCGS, CGS, CGS1, CS,26, cystathionine synthase, cystathionine synthetase, cystathionine-gamma-synthase, EC 4.2.99.9, homoserine O-transsuccinylase, homoserine transsuccinylase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
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