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Information on EC 2.5.1.41 - phosphoglycerol geranylgeranyltransferase

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IUBMB Comments
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria . Requires Mg2+ for maximal activity . It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate . The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
geranylgeranyl-transferase, geranylgeranyltransferase ii, gggp synthase, gggps, geranylgeranylglyceryl phosphate synthase, ((s)-gggp) synthase, (s)-3-o-geranylgeranylglyceryl phosphate synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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PATHWAY SOURCE
PATHWAYS
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