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Disease on EC 2.5.1.29 - geranylgeranyl diphosphate synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury.
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression.
Adenocarcinoma
Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma.
Adenocarcinoma of Lung
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Ataxia
Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition.
Azoospermia
The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis.
Bone Resorption
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Breast Neoplasms
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate.
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration.
Carcinoma, Hepatocellular
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis.
Cholestasis
Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
Dystocia
Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
Fatty Liver
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions.
geranylgeranyl diphosphate synthase deficiency
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling.
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury.
Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
Hearing Loss
GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.
Hyperinsulinism
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis.
Infections
Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection.
Biosynthesis of the Macrocyclic Diterpene Casbene in Castor Bean (Ricinus communis L.) Seedlings : Changes in Enzyme Levels Induced by Fungal Infection and Intracellular Localization of the Pathway.
Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin.
Insulin Resistance
Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway.
Leukemia
Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes.
Leukemia, Lymphoid
Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation.
Leukemia, Myeloid
In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors.
Liver Diseases
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions.
Liver Neoplasms
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis.
Lung Injury
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator-induced lung injury via regulation of TLR2/4-AP-1 signaling.
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression.
Malaria
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.
Multiple Myeloma
?-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors.
?-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Amides as bioisosteres of triazole-based geranylgeranyl diphosphate synthase inhibitors.
Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
In vivo evaluation of isoprenoid triazole bisphosphonate inhibitors of geranylgeranyl diphosphate synthase: impact of olefin stereochemistry on toxicity and biodistribution.
Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase.
Mumps
Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection.
Muscular Dystrophies
GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.
Neoplasm Metastasis
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.
Neoplasms
?-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Amides as bioisosteres of triazole-based geranylgeranyl diphosphate synthase inhibitors.
Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase.
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration.
Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator-induced lung injury via regulation of TLR2/4-AP-1 signaling.
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Suppression of MET Signaling Mediated by Pitavastatin and Capmatinib Inhibits Oral and Esophageal Cancer Cell Growth.
The intermediate enzymes of isoprenoid metabolism as anticancer targets.
Non-alcoholic Fatty Liver Disease
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions.
Obesity
The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis.
Pancreatic Neoplasms
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition.
Prostatic Neoplasms
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate.
Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models.
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.
Respiratory Distress Syndrome
Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator-induced lung injury via regulation of TLR2/4-AP-1 signaling.
Schistosomiasis
Characterization of farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni: potential drug targets.
Starvation
Regulation of mice liver regeneration by early growth response-1 through the GGPPS/RAS/MAPK pathway.
Ventilator-Induced Lung Injury
Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator-induced lung injury via regulation of TLR2/4-AP-1 signaling.