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Information on EC 2.5.1.15 - dihydropteroate synthase

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IUBMB Comments
The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase , while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25, dihydroneopterin aldolase .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pfdhps, dihydropteroate synthetase, pvdhps, folp1, rv1207, hppk-dhps, 7,8-dihydropteroate synthase, mtdhps, 6-hydroxymethyl-7,8-dihydropteroate synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate
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