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Information on EC 2.5.1.101 - N,N'-diacetyllegionaminate synthase

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IUBMB Comments
Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.
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Word Map
  • 2.5.1.101
  • ubiquitin-conjugating
  • polyubiquitination
  • ligases
  • ubiquitin-mediated
  • scfcdc4
  • multiubiquitination
  • ck2-mediated
  • scf-mediated
  • autoubiquitination
  • ub-conjugating
The enzyme appears in viruses and cellular organisms
Synonyms
legI, N,N'-diacetyllegionaminic acid synthase, NeuB, NeuB homologue, nonulosonic acid synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate
show the reaction diagram
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