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Information on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

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IUBMB Comments
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes .
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Word Map
  • 2.4.2.19
  • presenilins
  • abeta
  • notch
  • beta-amyloid
  • early-onset
  • intramembrane
  • nicastrin
  • amyloid-beta
  • fad
  • aspartyl
  • gamma-secretase
  • beta-peptide
  • beta-secretase
  • dementia
  • amyloidogenic
  • neuritic
  • endoproteolysis
  • nicotinic
  • hippocampal
  • neuropathological
  • senile
  • neurofibrillary
  • holoproteins
  • sh-sy5y
  • beta-site
  • ectodomain
  • beta-protein
  • adam10
  • secretase
  • betaapp
  • tangle
  • epsilon4
  • amyloidogenesis
  • non-demented
  • sappalpha
  • ad-related
  • angiopathy
  • 3-hydroxyanthranilic
  • hydroxyethylamine
  • abeta1-40
  • presenilin-dependent
  • isostere
  • alpha-secretase
  • non-amyloidogenic
  • intramembrane-cleaving
  • disease-linked
  • disintegrin
  • t-butyl
  • fad-linked
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
quinolinate phosphoribosyltransferase, quinolinic acid phosphoribosyltransferase, qaprtase, qprtase, nad pyrophosphorylase, quinolinate phosphoribosyl transferase, hqprtase, quinolate phosphoribosyltransferase, quinolinate phosphoribosyltransferase 2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
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