Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 2.4.1.92 - (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Scheideler, M.A.; Dawson, G.
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP
J. Neurochem.
46
1639-1643
1986
Rattus norvegicus
Manually annotated by BRENDA team
Dicesare, J.L.; Dain, J.A.
The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain
Biochim. Biophys. Acta
231
385-393
1971
Rattus norvegicus
Manually annotated by BRENDA team
Senn, H.J.; Cooper, C.; Warnke, P.C.; Wagner, M.; Decker, K.
Ganglioside biosynthesis in rat liver. Characterization of UDP-N-acetylgalactosamine - GM3 acetylgalactosaminyltransferase
Eur. J. Biochem.
120
59-67
1981
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Nagata, Y.; Yamashiro, S.; Yodoi, J.; Lloyd, K.O.; Shiku, H.; Furukawa, K.
Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides [published erratum appears in J Biol Chem 1994 Mar 4;269(9):7045]
J. Biol. Chem.
267
12082-12089
1992
Homo sapiens
Manually annotated by BRENDA team
Hashimoto, Y.; Sekine, M.; Iwasaki, K.; Suzuki, A.
Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver
J. Biol. Chem.
268
25857-25864
1993
Mus musculus
Manually annotated by BRENDA team
Pohlentz, G.; Klein, D.; Schwarzmann, G.; Schmitz, D.; Sandhoff, K.
Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver
Proc. Natl. Acad. Sci. USA
85
7044-7048
1988
Rattus norvegicus
Manually annotated by BRENDA team
Nagai, K.I.; Ishizuka, I.
Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain
J. Biochem.
101
1115-1127
1987
Rattus norvegicus
Manually annotated by BRENDA team
Yanagisawa, K.; Taniguchi, N.; Makita, A.
Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver
Biochim. Biophys. Acta
919
213-220
1987
Rattus norvegicus
Manually annotated by BRENDA team
Bieberich, E.; MacKinnon, S.; Silva, J.; Li, D.D.; Tencomnao, T.; Irwin, L.; Kapitonov, D.; Yu, R.K.
Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases
Biochemistry
41
11479-11487
2002
Mus musculus
Manually annotated by BRENDA team
Li, J.; Yen, T.Y.; Allende, M.L.; Joshi, R.K.; Cai, J.; Pierce, W.M.; Jaskiewicz, E.; Darling, D.S.; Macher, B.A.; Young, W.W., Jr.
Disulfide bonds of GM2 synthase homodimers. Antiparallel orientation of the catalytic domains
J. Biol. Chem.
275
41476-41486
2000
Cricetulus griseus
Manually annotated by BRENDA team
Jaskiewicz, E.; Zhu, G.; Taatjes, D.J.; Darling, D.S.; Zwanzig, G.E., Jr.; Young, W.W., Jr.
Cloned beta1,4N-acetylgalactosaminyltransferase: subcellular localization and formation of disulfide bonded species
Glycoconjugate J.
13
213-223
1996
Homo sapiens (Q00973), Homo sapiens
Manually annotated by BRENDA team
Zhu, G.; Jaskiewicz, E.; Bassi, R.; Darling, D.S.; Young, W.W., Jr.
beta1,4 N-Acetylgalactosaminyltransferase (GM2/GD2/GA2 synthase) forms homodimers in the endoplasmic reticulum: a strategy to test for dimerization of Golgi membrane proteins
Glycobiology
7
987-996
1997
Homo sapiens (Q00973)
Manually annotated by BRENDA team
Haraguchi, M.; Yamashiro, S.; Furukawa, K.; Takamiya, K.; Shiku, H.; Furukawa, K.
The effects of the site-directed removal of N-glycosylation sites from beta-1,4-N-acetylgalactosaminyltransferase on its function
Biochem. J.
312
273-280
1995
Homo sapiens (Q00973)
-
Manually annotated by BRENDA team
Ruan, S.; Raj, B.K.M.; Furukawa, K.; Lloyd, K.O.
Analysis of melanoma cells stably transfected with b1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression
Arch. Biochem. Biophys.
323
11-18
1995
Homo sapiens (Q00973)
Manually annotated by BRENDA team
Furukawa, K.; Takamiya, K.; Furukawa, K.
beta1,4-N-acetylgalactosaminyltransferase-GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides
Biochim. Biophys. Acta
1573
356-362
2002
Homo sapiens (Q00973), Mus musculus (Q09200)
Manually annotated by BRENDA team
Daniotti, J.L.; Martina, J.A.; Giraudo, C.G.; Zurita, A.R.; Maccioni, H.J.F.
GM3 alpha2,8-sialyltransferase (GD3 synthase): protein characterization and sub-Golgi location in CHO-K1 cells
J. Neurochem.
74
1711-1720
2000
Homo sapiens
Manually annotated by BRENDA team
Li, J.; Rancour, D.M.; Allende, M.L.; Worth, C.A.; Darling, D.S.; Gilbert, J.B.; Menon, A.K.; Young, W.W., Jr.
The DXD motif is required for GM2 synthase activity but is not critical for nucleotide binding
Glycobiology
11
217-229
2001
Homo sapiens (Q00973)
Manually annotated by BRENDA team
Klein, D.; Pohlentz, G.; Schwarzmann, G.; Sandhoff, K.
Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver
Eur. J. Biochem.
167
417-424
1987
Rattus norvegicus
Manually annotated by BRENDA team
Yusuf, H.K.M.; Schwarzmann, G.; Pohlentz, G.; Sandhoff, K.
Oligosialogangliosides inhibit GM2- and GD3-synthesis in isolated Golgi vesicles from rat liver
Biol. Chem. Hoppe-Seyler
368
455-462
1987
Rattus norvegicus
Manually annotated by BRENDA team
Ardail, D.; Popa, I.; Bodennec, J.; Louisot, P.; Schmitt, D.; Portoukalian, J.
The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases
Biochem. J.
371
1013-1019
2003
Rattus norvegicus
Manually annotated by BRENDA team
Gotoh, M.; Sato, T.; Kiyohara, K.; Kameyama, A.; Kikuchi, N.; Kwon, Y.D.; Ishizuka, Y.; Iwai, T.; Nakanishi, H.; Narimatsu, H.
Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine
FEBS Lett.
562
134-140
2004
Homo sapiens (Q76KP1)
Manually annotated by BRENDA team
Haines, N.; Irvine, K.D.
Functional analysis of Drosophila beta1,4-N-acetylgalactosaminyltransferases
Glycobiology
15
335-346
2005
Drosophila melanogaster
Manually annotated by BRENDA team
Giraudo, C.G.; Maccioni, H.J.F.
Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells
J. Biol. Chem.
278
40262-40271
2003
Cricetulus griseus
Manually annotated by BRENDA team
Vadaie, N.; Jarvis, D.L.
Molecular cloning and functional characterization of a lepidopteran insect beta4-N-acetylgalactosaminyltransferase with broad substrate specificity, a functional role in glycoprotein biosynthesis, and a potential functional role in glycolipid biosynthesis
J. Biol. Chem.
279
33501-33518
2004
Trichoplusia ni (Q6J4T9)
Manually annotated by BRENDA team
Kawar, Z.S.; Haslam, S.M.; Morris, H.R.; Dell, A.; Cummings, R.D.
Novel poly-GalNAcbeta1-4GlcNAc (LacdiNAc) and fucosylated poly-LacdiNAc N-glycans from mammalian cells expressing beta1,4-N-acetylgalactosaminyltransferase and alpha1,3-fucosyltransferase
J. Biol. Chem.
280
12810-12819
2005
Caenorhabditis elegans
Manually annotated by BRENDA team
Wendeler, M.; Reilaender, H.; Hoernschemeyer, J.; Schwarzmann, G.; Kolter, T.; Sandhoff, K.
Recombinant ganglioside GM2 synthase-expression in insect cells and enzyme assay
Methods Enzymol.
363
476-489
2003
Mus musculus
Manually annotated by BRENDA team
Sasaki, N.; Yoshida, H.; Fuwa, T.J.; Kinoshita-Toyoda, A.; Toyoda, H.; Hirabayashi, Y.; Ishida, H.; Ueda, R.; Nishihara, S.
Drosophila beta1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids
Biochem. Biophys. Res. Commun.
354
522-527
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Haines, N.; Stewart, B.A.
Functional roles for beta1,4-N-acetylgalactosaminyltransferase-A in Drosophila larval neurons and muscles
Genetics
175
671-679
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Ramakrishnan, B.; Qasba, P.K.
Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates
J. Mol. Biol.
365
570-576
2007
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Jacques, S.; Rich, J.R.; Ling, C.; Bundle, D.R.
Chemo-enzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications
Org. Biomol. Chem.
4
142-154
2006
Campylobacter jejuni, Campylobacter jejuni O:36
Manually annotated by BRENDA team
Martinez, C.; Hofmann, T.J.; Marino, R.; Dominici, M.; Horwitz, E.M.
Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs
Blood
109
4245-4248
2007
Homo sapiens (Q00973), Homo sapiens
Manually annotated by BRENDA team
Wang, H.R.; Hsieh, C.Y.; Twu, Y.C.; Yu, L.C.
Expression of the human Sda beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status
Glycobiology
18
104-113
2008
Homo sapiens
Manually annotated by BRENDA team
Furukawa, K.; Aixinjueluo, W.; Kasama, T.; Ohkawa, Y.; Yoshihara, M.; Ohmi, Y.; Tajima, O.; Suzumura, A.; Kittaka, D.; Furukawa, K.
Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21
J. Neurochem.
105
1057-1066
2008
Mus musculus (Q09200), Mus musculus
Manually annotated by BRENDA team
Ootsuka, S.; Asami, S.; Sasaki, T.; Yoshida, Y.; Nemoto, N.; Shichino, H.; Chin, M.; Mugishima, H.; Suzuki, T.
Useful markers for detecting minimal residual disease in cases of neuroblastoma
Biol. Pharm. Bull.
31
1071-1074
2008
Homo sapiens
Manually annotated by BRENDA team
Pukin, A.; Weijers, C.; van Lagen, B.; Wechselberger, R.; Sun, B.; Gilbert, M.; Karwaski, M.; Florack, D.; Jacobs, B.; Tio-Gillen, A.; van Belkum, A.; Endtz, H.; Visser, G.; Zuilhof, H.
GM3, GM2 and GM1 mimics designed for biosensing: chemoenzymatic synthesis, target affinities and 900 MHz NMR analysis
Carbohydr. Res.
343
636-650
2008
Campylobacter jejuni
Manually annotated by BRENDA team
Prinetti, A.; Aureli, M.; Illuzzi, G.; Prioni, S.; Nocco, V.; Scandroglio, F.; Gagliano, N.; Tredici, G.; Rodriguez-Menendez, V.; Chigorno, V.; Sonnino, S.
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells
Glycobiology
20
62-77
2010
Homo sapiens
Manually annotated by BRENDA team
Li, H.; Turley, S.D.; Liu, B.; Repa, J.J.; Dietschy, J.M.
GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice
J. Lipid Res.
49
1816-1828
2008
Mus musculus
Manually annotated by BRENDA team
Chen, L.C.; Brown, A.B.; Cheung, I.Y.; Cheung, N.K.; Kris, M.G.; Krug, L.M.
Analysis of GD2/GM2 synthase mRNA as a biomarker for small cell lung cancer
Lung Cancer
67
216-220
2010
Homo sapiens
Manually annotated by BRENDA team
Ohmi, Y.; Tajima, O.; Ohkawa, Y.; Mori, A.; Sugiura, Y.; Furukawa, K.; Furukawa, K.
Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues
Proc. Natl. Acad. Sci. USA
106
22405-22410
2009
Mus musculus
Manually annotated by BRENDA team
Song, N.; Kim, S.J.; Kwon, H.Y.; Son, S.W.; Kim, K.S.; Ahn, H.B.; Lee, Y.C.
Transcriptional activation of human GM3 synthase (hST3Gal V) gene by valproic acid in ARPE-19 human retinal pigment epithelial cells
BMB Rep.
44
405-409
2011
Homo sapiens
Manually annotated by BRENDA team
Suzuki, Y.; Yanagisawa, M.; Ariga, T.; Yu, R.K.
Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development
J. Neurochem.
116
874-880
2011
Mus musculus
Manually annotated by BRENDA team
Liu, Y.; Yan, S.; Wondimu, A.; Bob, D.; Weiss, M.; Sliwinski, K.; Villar, J.; Notario, V.; Sutherland, M.; Colberg-Poley, A.M.; Ladisch, S.
Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth
Oncogene
29
3297-3306
2010
Mus musculus
Manually annotated by BRENDA team
Miyata, M.; Ichihara, M.; Tajima, O.; Sobue, S.; Kambe, M.; Sugiura, K.; Furukawa, K.; Furukawa, K.
UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6
Biochem. Biophys. Res. Commun.
445
504-510
2014
Homo sapiens (Q00973)
Manually annotated by BRENDA team
Harlalka, G.V.; Lehman, A.; Chioza, B.; Baple, E.L.; Maroofian, R.; Cross, H.; Sreekantan-Nair, A.; Priestman, D.A.; Al-Turki, S.; McEntagart, M.E.; Proukakis, C.; Royle, L.; Kozak, R.P.; Bastaki, L.; Patton, M.; Wagner, K.; Coblentz, R.; Price, J.; Mezei, M.; Schlade-Bartusiak, K.; Platt, F.M.; Hurle, M.E.; Crosby, A.H.
Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis
Brain
136
3618-3624
2013
Homo sapiens (Q00973)
Manually annotated by BRENDA team
Kreutz, F.; dos Santos Petry, F.; Camassola, M.; Schein, V.; Guma, F.C.; Nardi, N.B.; Trindade, V.M.
Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I)
Gene
527
109-114
2013
Mus musculus (Q09200), Mus musculus, Mus musculus C57BL/6 (Q09200)
Manually annotated by BRENDA team
Klein, D.; Pohlentz, G.; Schwarzmann, G.; Sandhoff, K.
Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver
Eur. J. Biochem.
167
417-424
1987
Rattus norvegicus (Q10468)
Manually annotated by BRENDA team
Pohlentz, G.; Klein, D.; Schwarzmann, G.; Schmitz, D.; Sandhoff, K.
Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver
Proc. Natl. Acad. Sci. USA
85
7044-7048
1988
Rattus norvegicus (Q10468)
Manually annotated by BRENDA team
Chumpen Ramirez, S.; Ruggiero, F.M.; Daniotti, J.L.; Valdez Taubas, J.
Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation
Biochem. J.
474
2803-2816
2017
Mus musculus
Manually annotated by BRENDA team