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Information on EC 2.4.1.69 - type 1 galactoside alpha-(1,2)-fucosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase
IUBMB Comments
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
a-(1->/2)-L-GalT, alpha (1,2)fucosyltransferase, alpha (1,2)fucosyltransferase 2, alpha (1,2)fucosyltransferase I, alpha 1, 2-fucosyltransferase 1, alpha(1,2)-fucosyltransferase, alpha(1,2)-fucosyltransferase-I, alpha(1,2)fucosyltransferase, alpha(1,2)fucosyltransferase I, alpha-(1,2)-fucosyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
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