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Information on EC 2.4.1.47 - N-acylsphingosine galactosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.47 N-acylsphingosine galactosyltransferase
IUBMB Comments
This membrane-bound, endoplasmic reticulum-located enzyme catalyses the last step in the synthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. It has a strong preference for ceramides that contain hydroxylated fatty acids.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
ceramide galactosyltransferase, cerebroside synthase, CGalT, CGT, galactosyltransferase, uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, uridine diphosphogalactose-acylsphingosine, GALT, UDP galactose-N-acylsphingosine galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-galactose + a ceramide = UDP + a beta-D-galactosylceramide
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