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Information on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.5 glutaminyl-peptide cyclotransferase
IUBMB Comments
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-tRNA cyclotransferase, Golgi-resident glutaminyl cyclase, gQC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3
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PATHWAY SOURCE
PATHWAYS