Disease on EC 2.3.2.31 - RBR-type E3 ubiquitin transferase
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Adrenocortical Carcinoma
Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGF?, and Wnt/?-catenin signaling in adrenocortical carcinoma cells.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Amyotrophic Lateral Sclerosis
Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Arthritis, Rheumatoid
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Bacterial Infections
LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
Brain Injuries, Traumatic
The expression of TRIAD1 and DISC1 after traumatic brain injury and its influence on NSCs.
Breast Neoplasms
Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression.
Breast Neoplasms
Correction: The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor ? and modulates estrogen-stimulated breast cancer cell proliferation.
Breast Neoplasms
Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4.
Breast Neoplasms
Expression of the three components of linear ubiquitin assembly complex in breast cancer.
Breast Neoplasms
Metastasis-associated Protein 1 Drives Tumor Cell Migration and Invasion through Transcriptional Repression of RING Finger Protein 144A.
Breast Neoplasms
RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.
Breast Neoplasms
RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.
Breast Neoplasms
Solution structure of the zinc finger domain of human RNF144A ubiquitin ligase.
Breast Neoplasms
The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor ? and modulates estrogen-stimulated breast cancer cell proliferation.
Carcinogenesis
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Carcinogenesis
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Carcinoma, Hepatocellular
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Carcinoma, Ovarian Epithelial
RNF144A suppresses ovarian cancer stem cell properties and tumor progression through regulation of LIN28B degradation via the ubiquitin-proteasome pathway.
Cerebral Hemorrhage
Increased expression of Triad1 is associated with neuronal apoptosis after intracerebral hemorrhage in adult rats.
Chordoma
LINC00662 triggers malignant progression of chordoma by the activation of RNF144B via targeting miR-16-5p.
Chordoma
Long non-coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR-31 expression.
Colorectal Neoplasms
Taraxasterol acetate targets RNF31 to inhibit RNF31/p53 axis-driven cell proliferation in colorectal cancer.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Gaucher Disease
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Glioblastoma
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Glioma
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
HIV Infections
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
Infarction, Middle Cerebral Artery
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains.
Infections
NtRNF217, Encoding a Putative RBR E3 Ligase Protein of Nicotiana tabacum, Plays an Important Role in the Regulation of Resistance to Ralstonia solanacearum Infection.
Infections
The E3 ubiquitin ligase RNF144B is LPS-inducible in human, but not mouse, macrophages and promotes inducible IL-1? expression.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Influenza, Human
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Intellectual Disability
The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders.
Leukemia
An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice.
Leukemia
Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Leukemia
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.
Leukemia, B-Cell
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.
Leukemia, Myeloid, Acute
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.
Leukemia, Myeloid, Acute
The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.
Leukemia, Promyelocytic, Acute
Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Neoplasm Metastasis
Metastasis-associated Protein 1 Drives Tumor Cell Migration and Invasion through Transcriptional Repression of RING Finger Protein 144A.
Neoplasm Metastasis
miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer.
Neoplasm Metastasis
RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.
Neoplasms
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Neoplasms
Expression of the three components of linear ubiquitin assembly complex in breast cancer.
Neoplasms
HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy.
Neoplasms
Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells.
Neoplasms
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Neoplasms
Metastasis-associated Protein 1 Drives Tumor Cell Migration and Invasion through Transcriptional Repression of RING Finger Protein 144A.
Neoplasms
miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer.
Neoplasms
Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics.
Neoplasms
Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma.
Neoplasms
Phenotype-based single cell sequencing identifies diverse genetic subclones in CD133 positive cancer stem cells.
Neoplasms
Primary immunodeficiency with chronic enteropathy and developmental delay in a boy arising from a novel homozygous RIPK1 variant.
Neoplasms
Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31.
Neoplasms
Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.
Neoplasms
Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function.
Neoplasms
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Neoplasms
RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.
Neoplasms
RNF144A suppresses ovarian cancer stem cell properties and tumor progression through regulation of LIN28B degradation via the ubiquitin-proteasome pathway.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Ovarian Neoplasms
RNF144A suppresses ovarian cancer stem cell properties and tumor progression through regulation of LIN28B degradation via the ubiquitin-proteasome pathway.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinson Disease
Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice.
Parkinson Disease
Alternative mitochondrial quality control mediated by extracellular release.
Parkinson Disease
Autophagy and innate immunity: Insights from invertebrate model organisms.
Parkinson Disease
Identification & characterization of leucine-rich repeat kinase 2 & parkin RBR E3 ubiquitin protein ligase variants in patients with Parkinson's disease.
Parkinson Disease
LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10.
Parkinson Disease
Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning.
Parkinson Disease
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
Pituitary Neoplasms
MicroRNA-378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma.
Porcine Reproductive and Respiratory Syndrome
Autophagy and innate immunity: Insights from invertebrate model organisms.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.
Prostatic Neoplasms
miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer.
Psoriasis
Levels of miR-31 and its target genes in dermal mesenchymal cells of patients with psoriasis.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Disease, Chronic Obstructive
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
rbr-type e3 ubiquitin transferase deficiency
ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.
rbr-type e3 ubiquitin transferase deficiency
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Reperfusion Injury
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Spinal Cord Injuries
Triad1 regulates the expression and distribution of EHD1 contributing to the neurite outgrowth of neurons after spinal cord injury.
Spondylitis, Ankylosing
RAB5C, SYNJ1, and RNF19B promote male ankylosing spondylitis by regulating immune cell infiltration.
Stomach Neoplasms
Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function.
Urinary Bladder Neoplasms
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Vesicular Stomatitis
Autophagy and innate immunity: Insights from invertebrate model organisms.
Vesicular Stomatitis
HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner.
Virus Diseases
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
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