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Disease on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Acute Kidney Injury
Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2.
Adenocarcinoma
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Alzheimer Disease
Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors.
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
Arthritis
Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.
Bacterial Infections
SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis.
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Brain Injuries
Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury.
Brain Ischemia
Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5.
Breast Neoplasms
High-throughput screening of Sirtuin family of genes in breast cancer.
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
SIRT5 as a biomarker for response to anthracycline-taxane-based neoadjuvant chemotherapy in triple-negative breast cancer.
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Carcinogenesis
Emerging roles for SIRT5 in metabolism and cancer.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study.
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity.
SIRT5 downregulation is associated with poor prognosis in glioblastoma.
SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1.
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.
The growing landscape of succinylation links metabolism and heart disease.
Trending topics of SIRT1 in tumorigenicity.
Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration.
Carcinoma
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Carcinoma, Hepatocellular
Hypoxia-induced miR-3677-3p promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by suppressing SIRT5.
MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma.
SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1.
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration.
Carcinoma, Non-Small-Cell Lung
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
Carcinoma, Squamous Cell
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Cardiomegaly
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Cardiomyopathy, Hypertrophic
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
Colitis
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1? Production and to Prevent DSS-Induced Colitis in Mice.
Colonic Neoplasms
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration.
The role of SIRT5 and p53 proteins in the sensitivity of colon cancer cells to chemotherapeutic agent 5-Fluorouracil.
Colorectal Neoplasms
SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity.
[Coronavirus disease (COVID-19) and sirtuins].
COVID-19
[Coronavirus disease (COVID-19) and sirtuins].
Dermatitis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Diabetes Mellitus, Type 1
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Diabetes Mellitus, Type 2
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
SIRT3 Overexpression Attenuates Palmitate-Induced Pancreatic ?-Cell Dysfunction.
SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.
SIRT5 regulates pancreatic ?-cell proliferation and insulin secretion in type 2 diabetes.
Endometriosis
Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis?
Endotoxemia
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Epilepsy
SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2.
Fatty Liver
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.
Glioblastoma
SIRT5 downregulation is associated with poor prognosis in glioblastoma.
Heart Diseases
The growing landscape of succinylation links metabolism and heart disease.
Hyperalgesia
Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats.
Hyperglycemia
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Hypertension
Mitochondrial dysfunction-mediated decline in angiogenic capacity of endothelial progenitor cells is associated with capillary rarefaction in patients with hypertension via downregulation of CXCR4/JAK2/SIRT5 signaling.
Infections
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Insulin Resistance
Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.
Ischemic Stroke
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Leukemia
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Deregulation of mitochondrial sirtuins and OGG1-2a acts as a prognostic and diagnostic biomarker in leukemia.
Leukemia, Myeloid, Acute
SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.
Listeriosis
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Liver Diseases
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.
Liver Diseases, Alcoholic
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
Liver Neoplasms
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
Lung Neoplasms
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer.
Melanoma
Mitochondrial Sirtuins in Skin and Skin Cancers.
SIRT1 Regulates Lamellipodium Extension and Migration of Melanoma Cells.
Sirt5 is dispensable for BrafV600E -mediated cutaneous melanoma development and growth in vivo.
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
Metabolic Diseases
Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein.
Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
The role of mitochondrial sirtuins in health and disease.
Myocardial Infarction
Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism.
Functional genetic variants in the SIRT5 gene promoter in acute myocardial infarction.
Neoplasms
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer.
Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Emerging roles for SIRT5 in metabolism and cancer.
Expression and role of SIRT1 in hepatocellular carcinoma.
Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology.
Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein.
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma.
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity.
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
Sirt5 is dispensable for BrafV600E -mediated cutaneous melanoma development and growth in vivo.
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
SIRT5 regulates autophagy and apoptosis in gastric cancer cells.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors.
Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
The expression levels of the sirtuins in patients with BCC.
The role of mitochondrial sirtuins in health and disease.
Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration.
[Coronavirus disease (COVID-19) and sirtuins].
Neuralgia
Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats.
Neuroblastoma
Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells.
Neurodegenerative Diseases
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology.
The role of mitochondrial sirtuins in health and disease.
Non-alcoholic Fatty Liver Disease
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.
Obesity
SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.
Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions.
SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes.
Ovarian Neoplasms
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Pancreatic Neoplasms
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Parkinson Disease
Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease.
Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors.
Periapical Periodontitis
The possible role of sirtuin 5 in the pathogenesis of apical periodontitis.
Peritonitis
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Pneumonia
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Prostatic Neoplasms
Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1.
Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1.
protein acetyllysine n-acetyltransferase deficiency
High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities.
protein-lysine desuccinylase (nad+) deficiency
Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses.
Metabolic Characterization of a Sirt5 deficient mouse model.
NAD(+) dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.
Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease.
SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.
Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions.
SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2.
SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose-derived mesenchymal stem cells via metabolic switching.
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1? Production and to Prevent DSS-Induced Colitis in Mice.
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
Psoriasis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Reperfusion Injury
SIRT5 and post-translational protein modifications: A potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism.
Sarcoma, Kaposi
[Coronavirus disease (COVID-19) and sirtuins].
Seizures
SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2.
selenocysteine lyase deficiency
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.
Sepsis
Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses.
NAD(+) dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.
Staphylococcal Infections
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Starvation
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
Stomach Neoplasms
CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer.
Expression of SIRT5 protein in gastric cancer cells.
OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer.
SIRT5 regulates autophagy and apoptosis in gastric cancer cells.
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Stroke
Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury.
Sirtuin 5 promotes ischemia/reperfusion-induced blood-brain barrier damage after stroke.
Thrombosis
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Triple Negative Breast Neoplasms
SIRT5 as a biomarker for response to anthracycline-taxane-based neoadjuvant chemotherapy in triple-negative breast cancer.
Virus Diseases
Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses.