Reference on EC 2.3.1.B41 - protein-long-chain fatty-acyl-lysine deacylase (NAD+)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhu, A.Y.; Zhou, Y.; Khan, S.; Deitsch, K.W.; Hao, Q.; Lin, H.
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine
ACS Chem. Biol.
7
155-159
2012
Plasmodium falciparum (Q8IE47), Plasmodium falciparum isolate 3D7 (Q8IE47)
Chen, X.; Hao, B.; Liu, Y.; Dai, D.; Han, G.; Li, Y.; Wu, X.; Zhou, X.; Yue, Z.; Wang, L.; Cao, Y.; Liu, J.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma
Biochem. Biophys. Res. Commun.
446
364-369
2014
Homo sapiens (Q8N6T7), Homo sapiens
Liu, R.; Liu, H.; Ha, Y.; Tilton, R.G.; Zhang, W.
Oxidative stress induces endothelial cell senescence via downregulation of Sirt6
Biomed Res. Int.
2014
902842
2014
Homo sapiens (Q8N6T7), Homo sapiens
Ming, M.; Han, W.; Zhao, B.; Sundaresan, N.R.; Deng, C.X.; Gupta, M.P.; He, Y.Y.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer
Cancer Res.
74
5925-5933
2014
Mus musculus (P59941), Mus musculus, Homo sapiens (Q8N6T7), Homo sapiens
Merrick, C.J.; Duraisingh, M.T.
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity
Eukaryot. Cell
6
2081-291
2007
Plasmodium falciparum (Q8IE47), Plasmodium falciparum isolate 3D7 (Q8IE47)
Kokkonen, P.; Rahnasto-Rilla, M.; Mellini, P.; Jarho, E.; Lahtela-Kakkonen, M.; Kokkola, T.
Studying SIRT6 regulation using H3K56 based substrate and small molecules
Eur. J. Pharm. Sci.
63
71-76
2014
Homo sapiens (Q8N6T7)
Wu, M.; Dickinson, S.I.; Wang, X.; Zhang, J.
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder
Int. J. Clin. Exp. Pathol.
7
6504-6513
2014
Homo sapiens (Q8N6T7)
Pan, P.W.; Feldman, J.L.; Devries, M.K.; Dong, A.; Edwards, A.M.; Denu, J.M.
Structure and biochemical functions of SIRT6
J. Biol. Chem.
286
14575-14587
2011
Homo sapiens (Q8N6T7), Homo sapiens
Feldman, J.L.; Baeza, J.; Denu, J.M.
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins
J. Biol. Chem.
288
31350-31356
2013
Homo sapiens (Q8N6T7)
Jedrusik-Bode, M.; Studencka, M.; Smolka, C.; Baumann, T.; Schmidt, H.; Kampf, J.; Paap, F.; Martin, S.; Tazi, J.; Mller, K.M.; Krger, M.; Braun, T.; Bober, E.
The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
J. Cell Sci.
126
5166-5177
2013
Mus musculus (P59941)
Avalos, J.L.; Bever, K.M.; Wolberger, C.
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
Mol. Cell
17
855-868
2005
Archaeoglobus fulgidus (O30124)
Jiang, H.; Khan, S.; Wang, Y.; Charron, G.; He, B.; Sebastian, C.; Du, J.; Kim, R.; Ge, E.; Mostoslavsky, R.; Hang, H.C.; Hao, Q.; Lin, H.
SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine
Nature
496
110-113
2013
Homo sapiens (Q8N6T7), Homo sapiens
Cardinale, A.; de Stefano, M.C.; Mollinari, C.; Racaniello, M.; Garaci, E.; Merlo, D.
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response
Neurochem. Res.
40
59-69
2015
Mus musculus (P59941)
Gil, R.; Barth, S.; Kanfi, Y.; Cohen, H.Y.
SIRT6 exhibits nucleosome-dependent deacetylase activity
Nucleic Acids Res.
41
8537-8545
2013
Homo sapiens (Q8N6T7)
Ardestani, P.M.; Liang, F.
Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells
Nucleus
3
442-451
2012
Homo sapiens (Q8N6T7)
Fischer, F.; Gertz, M.; Suenkel, B.; Lakshminarasimhan, M.; Schutkowski, M.; Steegborn, C.
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition
PLoS One
7
e45098
2012
Archaeoglobus fulgidus (O30124)
Silberman, D.M.; Ross, K.; Sande, P.H.; Kubota, S.; Ramaswamy, S.; Apte, R.S.; Mostoslavsky, R.
SIRT6 is required for normal retinal function
PLoS One
9
e98831
2014
Homo sapiens (Q8N6T7)
Ringel, A.E.; Roman, C.; Wolberger, C.
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2
Protein Sci.
23
1686-1697
2014
Archaeoglobus fulgidus (O30124)
Piao, J.; Tsuji, K.; Ochi, H.; Iwata, M.; Koga, D.; Okawa, A.; Morita, S.; Takeda, S.; Asou, Y.
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
Sci. Rep.
3
3022
2013
Mus musculus (P59941)
Cea, M.; Cagnetta, A.; Adamia, S.; Acharya, C.; Tai, Y.T.; Fulciniti, M.; Ohguchi, H.; Munshi, A.; Acharya, P.; Bhasin, M.K.; Zhong, L.; Carrasco, R.; Monacelli, F.; Ballestrero, A.; Richardson, P.; Gobbi, M.; Lemoli, R.M.; Munshi, N.; Hideshima, T.; Nencioni, A.; Chauhan, D.; Anderson, K.C.
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells
Blood
127
1138-1150
2016
Homo sapiens (Q8N6T7), Homo sapiens
Hwang, B.J.; Jin, J.; Gao, Y.; Shi, G.; Madabushi, A.; Yan, A.; Guan, X.; Zalzman, M.; Nakajima, S.; Lan, L.; Lu, A.L.
SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp
BMC Mol. Biol.
16
12
2015
Mus musculus (P59941), Mus musculus
Feng, X.X.; Luo, J.; Liu, M.; Yan, W.; Zhou, Z.Z.; Xia, Y.J.; Tu, W.; Li, P.Y.; Feng, Z.H.; Tian, D.A.
Sirtuin 6 promotes transforming growth factor-beta1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence
Cancer Sci.
106
559-566
2015
Homo sapiens (Q8N6T7)
Rahnasto-Rilla, M.; Kokkola, T.; Jarho, E.; Lahtela-Kakkonen, M.; Moaddel, R.
N-acylethanolamines bind to SIRT6
ChemBioChem
17
77-81
2016
Homo sapiens (Q8N6T7)
Zhang, J.; Yin, X.J.; Xu, C.J.; Ning, Y.X.; Chen, M.; Zhang, H.; Chen, S.F.; Yao, L.Q.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression
Eur. Rev. Med. Pharmacol. Sci.
19
818-824
2015
Homo sapiens (Q8N6T7), Homo sapiens
Maksin-Matveev, A.; Kanfi, Y.; Hochhauser, E.; Isak, A.; Cohen, H.Y.; Shainberg, A.
Sirtuin 6 protects the heart from hypoxic damage
Exp. Cell Res.
330
81-90
2015
Mus musculus (P59941), Mus musculus
Hu, S.; Liu, H.; Ha, Y.; Luo, X.; Motamedi, M.; Gupta, M.P.; Ma, J.X.; Tilton, R.G.; Zhang, W.
Posttranslational modification of Sirt6 activity by peroxynitrite
Free Radic. Biol. Med.
79
176-185
2015
Homo sapiens (Q8N6T7), Homo sapiens
Etchegaray, J.P.; Chavez, L.; Huang, Y.; Ross, K.N.; Choi, J.; Martinez-Pastor, B.; Walsh, R.M.; Sommer, C.A.; Lienhard, M.; Gladden, A.; Kugel, S.; Silberman, D.M.; Ramaswamy, S.; Mostoslavsky, G.; Hochedlinger, K.; Goren, A.; Rao, A.; Mostoslavsky, R.
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine
Nat. Cell Biol.
17
545-557
2015
Mus musculus (P59941)
Zhang, X.; Khan, S.; Jiang, H.; Antonyak, M.A.; Chen, X.; Spiegelman, N.A.; Shrimp, J.H.; Cerione, R.A.; Lin, H.
Identifying the functional contribution of the defatty-acylase activity of SIRT6
Nat. Chem. Biol.
12
614-620
2016
Homo sapiens (Q8N6T7)
Tasselli, L.; Xi, Y.; Zheng, W.; Tennen, R.I.; Odrowaz, Z.; Simeoni, F.; Li, W.; Chua, K.F.
SIRT6 deacetylates H3K18Ac at pericentric chromatin to prevent mitotic errors and cellular senescence
Nat. Struct. Mol. Biol.
23
434-440
2016
Homo sapiens (Q8N6T7), Homo sapiens
Liu, J.; Zheng, W.
Cyclic peptide-based potent human SIRT6 inhibitors
Org. Biomol. Chem.
14
5928-5935
2016
Homo sapiens (Q8N6T7), Homo sapiens
Tian, K.; Liu, Z.; Wang, J.; Xu, S.; You, T.; Liu, P.
Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor kappaB signaling
Transl. Res.
165
374-386
2015
Rattus norvegicus (Q4FZY2)
Cui, X.; Yao, L.; Yang, X.; Gao, Y.; Fang, F.; Zhang, J.; Wang, Q.; Chang, Y.
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK
Am. J. Physiol. Endocrinol. Metab.
313
E493-E505
2017
Mus musculus (P59941), Mus musculus, Mus musculus C57BL/6 (P59941)
You, W.; Rotili, D.; Li, T.M.; Kambach, C.; Meleshin, M.; Schutkowski, M.; Chua, K.F.; Mai, A.; Steegborn, C.
Structural basis of sirtuin 6 activation by synthetic small molecules
Angew. Chem. Int. Ed. Engl.
56
1007-1011
2017
Homo sapiens (Q8N6T7), Homo sapiens
Hong, J.; Mei, C.; Abbas Raza, S.; Khan, R.; Cheng, G.; Zan, L.
SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKalpha signaling pathway
Arch. Biochem. Biophys.
681
108260
2020
Bos taurus (A5D7K6), Bos taurus
Sosnowska, B.; Mazidi, M.; Penson, P.; Gluba-Brzozka, A.; Rysz, J.; Banach, M.
The sirtuin family members SIRT1, SIRT3 and SIRT6 their role in vascular biology and atherogenesis
Atherosclerosis
265
275-282
2017
Homo sapiens (Q8N6T7), Homo sapiens
Sun, S.; Liu, Z.; Feng, Y.; Shi, L.; Cao, X.; Cai, Y.; Liu, B.
Sirt6 deacetylase activity regulates circadian rhythms via Per2
Biochem. Biophys. Res. Commun.
511
234-238
2019
Mus musculus (P59941)
Kaluski, S.; Portillo, M.; Besnard, A.; Stein, D.; Einav, M.; Zhong, L.; Ueberham, U.; Arendt, T.; Mostoslavsky, R.; Sahay, A.; Toiber, D.
Neuroprotective functions for the histone deacetylase SIRT6
Cell Rep.
18
3052-3062
2017
Mus musculus (P59941), Homo sapiens (Q8N6T7), Homo sapiens
Pan, H.; Guan, Di; Liu, X.; Li, J.; Wang, L.; Wu5, J.; Zhou1, J.; Zhang, W.; Ren, R.; Zhang, W.; Li, Y.; Yang, J.; Hao, Y.; Yuan, T.; Yuan, G.; Wang, H.; Ju, Z.; Mao, Z.; Li, J.; Qu, J.; Tang, F.; Liu, G.-H.
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
Cell Res.
26
190-205
2016
Homo sapiens (Q8N6T7), Homo sapiens
Jin, Z.; Xiao, Y.; Yao, F.; Wang, B.; Zheng, Z.; Gao, H.; Lv, X.; Chen, L.; He, Y.; Wang, W.; Lin, R.
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation
Exp. Cell Res.
387
111744
2020
Mus musculus (P59941), Homo sapiens (Q8N6T7)
Sociali, G.; Grozio, A.; Caffa, I.; Schuster, S.; Becherini, P.; Damonte, P.; Sturla, L.; Fresia, C.; Passalacqua, M.; Mazzola, F.; Raffaelli, N.; Garten, A.; Kiess, W.; Cea, M.; Nencioni, A.; Bruzzone, S.
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells
FASEB J.
33
3704-3717
2019
Homo sapiens (Q8N6T7)
Harlan, B.; Pehar, M.; Killoy, K.; Vargas, M.
Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1
FASEB J.
33
7084-7091
2019
Homo sapiens (Q8N6T7), Homo sapiens
Garcia-Peterson, L.; Ndiaye, M.; Singh, C.; Chhabra, G.; Huang, W.; Ahmad, N.
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma
Genes Cancer
8
701-712
2017
Homo sapiens (Q8N6T7), Homo sapiens
Ferrer, C.; Alders, M.; Postma, A.; Park, S.; Klein, M.; Cetinbas, M.; Pajkrt, E.; Glas, A.; van Koningsbruggen, S.; Christoffels, V.; Mannens, M.; Knegt, L.; Etchegaray, J.; Sadreyev, R.; Denu, J.; Mostoslavsky, G.; van Maarle, M.; Mostoslavsky, R.
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
Genes Dev.
32
373-388
2018
Homo sapiens (Q8N6T7), Homo sapiens, Mus musculus (P59941), Mus musculus
Fan, Y.; Yang, Q.; Yang, Y.; Gao, Z.; Ma, Y.; Zhang, L.; Liang, W.; Ding, G.
Sirt6 suppresses high glucose-induced mitochondrial dysfunction and apoptosis in podocytes through AMPK activation
Int. J. Biol. Sci.
15
701-713
2019
Mus musculus (P59941), Homo sapiens (Q8N6T7), Homo sapiens, Mus musculus C57BL/6 (P59941)
Klein, M.A.; Liu, C.; Kuznetsov, V.I.; Feltenberger, J.B.; Tang, W.; Denu, J.M.
Mechanism of activation for the sirtuin 6 protein deacylase
J. Biol. Chem.
295
1385-1399
2020
Homo sapiens (Q8N6T7)
Zhang, Q.; Tu, W.; Tian, K.; Han, L.; Wang, Q.; Chen, P.; Zhou, X.
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-beta1/Smad2 and nuclear factor-kappaB signaling pathways in human fetal lung fibroblasts
J. Cell. Biochem.
120
93-104
2019
Homo sapiens (Q8N6T7), Homo sapiens
You, W.; Steegborn, C.
Structural basis of sirtuin 6 inhibition by the hydroxamate trichostatin A implications for protein deacylase drug development
J. Med. Chem.
61
10922-10928
2018
Homo sapiens (Q8N6T7)
Cai, J.; Liu, Z.; Huang, X.; Shu, S.; Hu, X.; Zheng, M.; Tang, C.; Liu, Y.; Chen, G.; Sun, L.; Liu, H.; Liu, F.; Cheng, J.; Dong, Z.
The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking beta-catenin targetgene expression
Kidney Int.
97
106-118
2020
Homo sapiens (Q8N6T7)
Han, L.; Jia, L.; Wu, F.; Huang, C.
Sirtuin6 (SIRT6) promotes the EMT of hepatocellular carcinoma by stimulating autophagic degradation of E-cadherin
Mol. Cancer Res.
17
2267-2280
2019
Homo sapiens
Sociali, G.; Liessi, N.; Grozio, A.; Caffa, I.; Parenti, M.; Ravera, S.; Tasso, B.; Benzi, A.; Nencioni, A.; Del Rio, A.; Robina, I.; Millo, E.; Bruzzone, S.
Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules
Mol. Divers.
24
655-671
2019
Homo sapiens (Q8N6T7)
Hu, J.; Deng, F.; Hu, X.; Zhang, W.; Zeng, X.; Tian, X.
Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity
Oncol. Rep.
40
3635-3644
2018
Homo sapiens (Q8N6T7)
Chang, A.; Ferrer, C.; Mostoslavsky, R.
SIRT6, a mammalian deacylase with multitasking abilities
Physiol. Rev.
100
145-169
2020
Homo sapiens (Q8N6T7), Mus musculus (P59941)
Samant, S.; Kanwal, A.; Pillai, V.; Bao, R.; Gupta, M.
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
Sci. Rep.
7
11744
2017
Mus musculus (P59941), Homo sapiens (Q8N6T7)
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