Disease on EC 2.3.1.B41 - protein-long-chain fatty-acyl-lysine deacylase (NAD+)
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Acne Vulgaris
Sirtuin6 inhibits c-triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1/CGRP.
Acute Kidney Injury
Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.
Acute Kidney Injury
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.
Acute Lung Injury
Sirtuin 6 mitigated LPS-induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2-related factor 2.
Adenocarcinoma
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
Adenocarcinoma
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.
Adenocarcinoma of Lung
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Adenocarcinoma of Lung
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
Adenoviridae Infections
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
Adrenocortical Carcinoma
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-?B signaling.
Alzheimer Disease
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes.
Alzheimer Disease
Effect of Colloidal Aqueous Solution of Fullerene (C60) in the Presence of a P-Glycoprotein Inhibitor (Verapamil) on Spatial Memory and Hippocampal Expression of Sirtuin6, SELADIN1, and AQP1 Genes in a Rat Model of Alzheimer's Disease.
Alzheimer Disease
Efficacy and safety of NAD+ ADP-ribosyltransferase 1 agonist versus Donepezil in elderly Chinese patients with Alzheimer disease: A novel target for effective therapy.
Alzheimer Disease
SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis.
Alzheimer Disease
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
Alzheimer Disease
The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.
Alzheimer Disease
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Anaphylaxis
Sirtuin 6 is a negative regulator of Fc?RI signaling and anaphylactic responses.
Arthritis
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Arthritis, Experimental
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.
Arthritis, Rheumatoid
Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6.
Arthritis, Rheumatoid
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Arthritis, Rheumatoid
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
Asthma
Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-?1/Smad3 pathway and c-Jun in asthma models.
Asthma
Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma.
Atherosclerosis
Correction to: SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis.
Atherosclerosis
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Atherosclerosis
ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.
Atherosclerosis
Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.
Atherosclerosis
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.
Atherosclerosis
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1? and reactive oxygen species.
Atherosclerosis
SIRT6 protects against endothelial dysfunction and atherosclerosis in mice.
Atherosclerosis
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis.
Atherosclerosis
SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.
Atherosclerosis
Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells.
Atherosclerosis
Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction.
Atherosclerosis
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.
Autoimmune Diseases
Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease.
Autoimmune Diseases
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Bone Diseases, Metabolic
Loss of Sirtuin 6 in osteoblast lineage cells activates osteoclasts, resulting in osteopenia.
Bone Diseases, Metabolic
Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation.
Bone Resorption
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Bone Resorption
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor ?.
Bone Resorption
Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption.
Brain Diseases
Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction.
Brain Injuries
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
Brain Injuries
SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells.
Brain Ischemia
Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage.
Brain Ischemia
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
Brain Ischemia
MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway.
Breast Neoplasms
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Breast Neoplasms
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Breast Neoplasms
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Breast Neoplasms
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
Breast Neoplasms
Icariin-induced inhibition of SIRT6/NF-?B triggers redox mediated apoptosis and enhances anti-tumor immunity in TNBC.
Breast Neoplasms
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Breast Neoplasms
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells.
Breast Neoplasms
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.
Breast Neoplasms
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
Breast Neoplasms
SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling.
Breast Neoplasms
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
Breast Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Breast Neoplasms
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Breast Neoplasms
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Breast Neoplasms
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
Carcinogenesis
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
Carcinogenesis
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Carcinogenesis
CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo.
Carcinogenesis
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Carcinogenesis
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Carcinogenesis
Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma.
Carcinogenesis
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
Carcinogenesis
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Carcinogenesis
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Carcinogenesis
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Carcinogenesis
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.
Carcinogenesis
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Carcinogenesis
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Carcinogenesis
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
Carcinogenesis
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-?B signaling.
Carcinogenesis
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
Carcinogenesis
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.
Carcinogenesis
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
Carcinogenesis
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
Carcinogenesis
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
Carcinogenesis
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
Carcinogenesis
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
Carcinogenesis
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Carcinogenesis
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
Carcinogenesis
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
Carcinogenesis
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
Carcinogenesis
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
Carcinogenesis
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Carcinoma
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Carcinoma
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Carcinoma
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
Carcinoma
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Carcinoma
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
Carcinoma
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Carcinoma
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Carcinoma
The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells.
Carcinoma
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Carcinoma, Ductal
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Carcinoma, Hepatocellular
Coordination of FOXA2 and SIRT6 suppresses the hepatocellular carcinoma progression through ZEB2 inhibition.
Carcinoma, Hepatocellular
Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Identification of a cellularly active SIRT6 allosteric activator.
Carcinoma, Hepatocellular
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Carcinoma, Hepatocellular
NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.
Carcinoma, Hepatocellular
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
Carcinoma, Hepatocellular
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
Carcinoma, Hepatocellular
SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression.
Carcinoma, Hepatocellular
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
Carcinoma, Hepatocellular
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
Carcinoma, Hepatocellular
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
Carcinoma, Hepatocellular
SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway.
Carcinoma, Hepatocellular
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal?regulated kinase signaling pathway.
Carcinoma, Hepatocellular
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Carcinoma, Hepatocellular
Sirtuin 6 promotes transforming growth factor-?1/H2 O2 /HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Carcinoma, Hepatocellular
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
Carcinoma, Hepatocellular
The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth.
Carcinoma, Hepatocellular
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Carcinoma, Intraductal, Noninfiltrating
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Carcinoma, Non-Small-Cell Lung
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Carcinoma, Non-Small-Cell Lung
Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway.
Carcinoma, Non-Small-Cell Lung
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Carcinoma, Non-Small-Cell Lung
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Carcinoma, Non-Small-Cell Lung
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Carcinoma, Non-Small-Cell Lung
Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
Carcinoma, Non-Small-Cell Lung
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression.
Carcinoma, Non-Small-Cell Lung
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Carcinoma, Non-Small-Cell Lung
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Carcinoma, Non-Small-Cell Lung
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Carcinoma, Renal Cell
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Carcinoma, Renal Cell
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Carcinoma, Squamous Cell
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Carcinoma, Squamous Cell
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Cardiomegaly
Deubiquitinase Ubiquitin-Specific Protease 10 Deficiency Regulates Sirt6 signaling and Exacerbates Cardiac Hypertrophy.
Cardiomegaly
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Cardiomegaly
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
Cardiomegaly
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
Cardiomegaly
SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.
Cardiomegaly
SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity.
Cardiomegaly
Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-?B-dependent transcriptional activity.
Cardiomegaly
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
Cardiomegaly
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.
Cardiomegaly
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Cardiomyopathies
Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy.
Cardiotoxicity
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a.
Cardiovascular Diseases
Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.
Cardiovascular Diseases
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.
Cardiovascular Diseases
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Cardiovascular Diseases
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Cardiovascular Diseases
Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.
Cardiovascular Diseases
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
Cardiovascular Diseases
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
Cardiovascular Diseases
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.
Cardiovascular Diseases
Sirtuin 6: a potential therapeutic target for cardiovascular diseases.
Cholera
A note on the predicted secondary structures of the active chains of cholera and diphtheria toxins.
Cholera
ADP-ribosyl transferase activity of cholera toxin polypeptide A1 and the effect of limited trypsinolysis.
Cholera
ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins.
Colitis
Interferon-? inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.
Colitis
Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice.
Colonic Neoplasms
Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Colonic Neoplasms
Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities.
Colonic Neoplasms
Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.
Colonic Neoplasms
FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.
Colonic Neoplasms
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Colonic Neoplasms
PKC? Phosphorylates SIRT6 to Mediate Fatty Acid ?-Oxidation in Colon Cancer Cells.
Colonic Neoplasms
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Colonic Neoplasms
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
Colonic Neoplasms
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.
Colonic Neoplasms
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
Colorectal Neoplasms
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Colorectal Neoplasms
SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A.
Colorectal Neoplasms
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Colorectal Neoplasms
Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer.
Congenital Abnormalities
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Coronary Artery Disease
Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
Cystic Fibrosis
The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.
Dengue
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-?B p65.
Dermatitis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Dermatitis, Atopic
A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis.
Dermatitis, Atopic
A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
Dermatitis, Atopic
Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.
Dermatitis, Atopic
Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis.
Dermatitis, Atopic
The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
Diabetes Complications
New insight in molecular mechanisms regulating SIRT6 expression in diabetes: Hyperglycaemia effects on SIRT6 DNA methylation.
Diabetes Mellitus
Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.
Diabetes Mellitus
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Diabetes Mellitus
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Diabetes Mellitus
Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: An immunohistochemical study.
Diabetes Mellitus, Type 2
Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.
Diabetes Mellitus, Type 2
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
Diabetes Mellitus, Type 2
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Diabetes Mellitus, Type 2
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Diabetes Mellitus, Type 2
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of sodium-glucose co-transporter2 inhibitor treatment.
Diabetic Cardiomyopathies
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
Diabetic Cardiomyopathies
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Diabetic Nephropathies
FOXO3a Protects against Kidney Injury in Type II Diabetic Nephropathy by Promoting Sirt6 Expression and Inhibiting Smad3 Acetylation.
Diabetic Nephropathies
Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy.
Diabetic Nephropathies
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Diabetic Retinopathy
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.
Diabetic Retinopathy
Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.
Diphtheria
A note on the predicted secondary structures of the active chains of cholera and diphtheria toxins.
Diphtheria
An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.
Diphtheria
Genetic assembly and selective toxicity of diphtheria-toxin-related polypeptide hormone fusion proteins.
Diphtheria
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks.
Dyslipidemias
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.
Encephalomyelitis
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Encephalomyelitis
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration.
Encephalomyelitis, Autoimmune, Experimental
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Encephalomyelitis, Autoimmune, Experimental
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration.
Endometrial Neoplasms
Molecular markers of endometrial carcinoma detected in uterine aspirates.
Endometriosis
Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis?
Esophageal Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Fanconi Anemia
The basal and the mutagen-induced levels of ADP-ribosyl transferase activity are not modified in Fanconi's anemia cells.
Farber Lipogranulomatosis
Leukocyte and plasma N-laurylsphingosine deacylase (ceramidase) in Farber disease.
Farber Lipogranulomatosis
The synthetic pathway for glucosylsphingosine in cultured fibroblasts.
Fatty Liver
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Fatty Liver
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Fatty Liver
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Fetal Death
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Fetal Diseases
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Gastrointestinal Neoplasms
Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysis.
Glioblastoma
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Glioblastoma
Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells.
Glioma
Histone deacetylase SIRT6 inhibits glioma cell growth through down-regulating NOTCH3 expression.
Glioma
Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation.
Glioma
MST1 suppresses viability and promotes apoptosis of glioma cells via upregulating SIRT6 expression.
Glioma
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Glioma
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
Glioma
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
Glioma
Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells.
Glucose Intolerance
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans.
Glucose Intolerance
Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis.
Glucose Intolerance
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Heart Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Heart Diseases
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Heart Diseases
The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling.
Heart Failure
Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.
Heart Failure
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Heart Failure
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Hematologic Neoplasms
Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.
Hematologic Neoplasms
Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.
Hematuria
Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.
Hepatitis B
SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors ?.
Hepatitis, Alcoholic
The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice.
Hodgkin Disease
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Huntington Disease
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Hypercholesterolemia
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hypercholesterolemia
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6.
Hyperglycemia
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Hyperglycemia
Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs.
Hyperglycemia
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Hyperglycemia
Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis.
Hypersensitivity
Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction.
Hypersensitivity
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
Hypertension
Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling.
Hypertension
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
Hypertension
SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling.
Hypertrophy, Left Ventricular
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Hypoglycemia
A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.
Hypoglycemia
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Hypoglycemia
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
Hypoglycemia
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
Idiopathic Pulmonary Fibrosis
Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-?1/Smad3 signaling.
Idiopathic Pulmonary Fibrosis
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-?1/Smad2 and nuclear factor-?B signaling pathways in human fetal lung fibroblasts.
Infarction, Middle Cerebral Artery
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
Infarction, Middle Cerebral Artery
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Infections
Antimalarial activity of inhibitors of ADP-ribosyl transferase against Plasmodium yoelii infection in mice. 1. Preliminary data.
Infections
Bst1 is required for Candida albicans infecting host via facilitating cell wall anchorage of Glycosylphosphatidyl inositol anchored proteins.
Infections
Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.
Infections
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-?B p65.
Infections
Sirtuin 6 Attenuates Kaposi's Sarcoma-associated herpesvirus (KSHV) Reactivation via Suppressing the Ori-Lyt Activity and Expression of RTA.
Insulin Resistance
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans.
Insulin Resistance
Administration of kynurenic acid reduces hyperlipidemia-induced inflammation and insulin resistance in skeletal muscle and adipocytes.
Insulin Resistance
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Insulin Resistance
Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.
Insulin Resistance
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Insulin Resistance
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Insulin Resistance
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Insulin Resistance
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.
Insulin Resistance
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
Insulin Resistance
Sirt6 deletion in hepatocytes increases insulin sensitivity of female mice by enhancing ER? expression.
Insulin Resistance
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Insulin Resistance
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Insulin Resistance
Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.
Intervertebral Disc Degeneration
Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.
Intervertebral Disc Degeneration
Sirtuin 6 prevents matrix degradation through inhibition of the NF-?B pathway in intervertebral disc degeneration.
Intestinal Volvulus
Detection of adenosine diphosphate-ribosyl transferase activity in the filarial worm, Onchocerca volvulus.
Ischemic Stroke
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Ischemic Stroke
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Ischemic Stroke
Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.
Kidney Diseases
Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity.
Kidney Diseases
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Kidney Neoplasms
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Leukemia
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Leukemia
Author Correction: Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Leukemia
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
Leukemia
Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.
Leukemia
Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.
Leukemia, Myeloid, Acute
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Leukemia, Myeloid, Acute
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.
Leukemia, Myeloid, Acute
MYC upregulated LINC00319 promotes human acute myeloid leukemia (AML) cells growth through stabilizing SIRT6.
Leukemia, Myeloid, Acute
SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.
Leukemia, Myeloid, Acute
Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition.
Liver Cirrhosis
Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells.
Liver Cirrhosis
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Liver Cirrhosis
Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-?1/Smad3 pathway and c-Jun in asthma models.
Liver Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Liver Diseases
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis.
Liver Diseases
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Liver Diseases
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Liver Diseases
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Liver Diseases
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
Liver Diseases
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Liver Diseases
The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice.
Liver Diseases
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
Liver Neoplasms
Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity.
Liver Neoplasms
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
Liver Neoplasms
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
Liver Neoplasms
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
Lung Injury
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Lung Neoplasms
?-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.
Lung Neoplasms
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Lung Neoplasms
Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway.
Lung Neoplasms
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Lung Neoplasms
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Lung Neoplasms
Influence of SIRT6 regulation of cellular glycometabolism on radiosensitivity of non-small-cell lung cancer A549 cells.
Lung Neoplasms
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
Lung Neoplasms
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells.
Lung Neoplasms
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Lung Neoplasms
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Lung Neoplasms
Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines.
Lung Neoplasms
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
Lung Neoplasms
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Lung Neoplasms
SIRT6 overexpression inhibits HIF1? expression and its impact on tumor angiogenesis in lung cancer.
Lung Neoplasms
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression.
Lung Neoplasms
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Lung Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Lung Neoplasms
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Lung Neoplasms
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Lymphatic Metastasis
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Lymphatic Metastasis
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Lymphatic Metastasis
Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer.
Lymphatic Metastasis
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Lymphoma
The effects of benzamide ADP-ribosyl transferase inhibitors on cell survival and DNA strand-break repair in irradiated mammalian cells.
Lymphoma, B-Cell
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
Lymphoma, B-Cell
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Lymphoma, Large B-Cell, Diffuse
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
Medulloblastoma
RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein.
Melanoma
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Melanoma
CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo.
Melanoma
Selection Signatures Analysis Reveals Genes Associated with High-Altitude Adaptation in Tibetan Goats from Nagqu, Tibet.
Melanoma
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling.
Melanoma
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.
Melanoma
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
Metabolic Diseases
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Metabolic Diseases
SIRT6 protects against pathological damage caused by diet-induced obesity.
Metabolic Diseases
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPAR?.
Metabolic Diseases
Sirtuins as endogenous regulators of lung fibrosis: A current perspective.
Metabolic Diseases
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Metabolic Syndrome
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Metabolic Syndrome
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Metabolic Syndrome
SIRT6 protects against pathological damage caused by diet-induced obesity.
Multiple Myeloma
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Muscular Atrophy
Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.
Muscular Atrophy
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
Myocardial Infarction
Metformin Therapy Effects on the Expression of Sodium-Glucose Cotransporter 2, Leptin, and SIRT6 Levels in Pericoronary Fat Excised from Pre-Diabetic Patients with Acute Myocardial Infarction.
Nasal Polyps
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Nasal Polyps
Sirtuin 6 modulates hypoxia-induced autophagy in nasal polyp fibroblasts via inhibition of glycolysis.
Nasopharyngeal Carcinoma
SIRT6 inhibits metastasis by suppressing SNAIL expression in nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-?B signaling.
Neoplasm Metastasis
Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.
Neoplasm Metastasis
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Neoplasm Metastasis
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Neoplasm Metastasis
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Neoplasm Metastasis
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Neoplasm Metastasis
Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer.
Neoplasm Metastasis
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Neoplasm Metastasis
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
Neoplasm Metastasis
SIRT6 inhibits metastasis by suppressing SNAIL expression in nasopharyngeal carcinoma cells.
Neoplasm Metastasis
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
Neoplasm Metastasis
SIRT6 Loss Promotes PDAC Progression by Epigenetic Induction of LIN28B.
Neoplasm Metastasis
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
Neoplasm Metastasis
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Neoplasm Metastasis
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
Neoplasm Metastasis
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
Neoplasm Metastasis
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Neoplasm Metastasis
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
Neoplasm Metastasis
Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis.
Neoplasm Metastasis
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Neoplasms
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.
Neoplasms
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.
Neoplasms
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes.
Neoplasms
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
Neoplasms
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Neoplasms
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.
Neoplasms
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Neoplasms
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
Neoplasms
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Neoplasms
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response.
Neoplasms
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.
Neoplasms
Changes in the response of the RIF-1 tumour to melphalan in vivo induced by inhibitors of nuclear ADP-ribosyl transferase.
Neoplasms
Chemical enhancement of cisplatin cytotoxicity in a human ovarian and cervical cancer cell line.
Neoplasms
CK2?/CSNK2A1 Induces Resistance to Doxorubicin through SIRT6-Mediated Activation of the DNA Damage Repair Pathway.
Neoplasms
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Neoplasms
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes.
Neoplasms
Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-? Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.
Neoplasms
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
Neoplasms
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Neoplasms
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
Neoplasms
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Neoplasms
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Neoplasms
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Neoplasms
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Neoplasms
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.
Neoplasms
Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities.
Neoplasms
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Neoplasms
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Neoplasms
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
Neoplasms
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Neoplasms
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Neoplasms
Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice.
Neoplasms
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Neoplasms
Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.
Neoplasms
In silico screening of small molecule modulators and their binding studies against human sirtuin-6 protein.
Neoplasms
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics.
Neoplasms
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Neoplasms
Inhibitors of ADP-ribosyl transferase suppress the mitogenic actions exerted by tumour promoters, but not those evoked by peptide mitogens, in primary neonatal rat hepatocytes.
Neoplasms
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Neoplasms
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.
Neoplasms
Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products.
Neoplasms
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
Neoplasms
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Neoplasms
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Neoplasms
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators.
Neoplasms
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Neoplasms
MiR-654-5p regulated cell progression and tumor growth through targeting SIRT6 in osteosarcoma.
Neoplasms
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.
Neoplasms
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Neoplasms
Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
Neoplasms
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Neoplasms
Novel tools to analyze the function of Salmonella effectors show that SvpB ectopic expression induces cell cycle arrest in tumor cells.
Neoplasms
NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma.
Neoplasms
Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy.
Neoplasms
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Neoplasms
Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin.
Neoplasms
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Neoplasms
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Neoplasms
PKC? Phosphorylates SIRT6 to Mediate Fatty Acid ?-Oxidation in Colon Cancer Cells.
Neoplasms
Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation.
Neoplasms
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Neoplasms
Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence.
Neoplasms
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Neoplasms
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Neoplasms
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Neoplasms
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells.
Neoplasms
Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines.
Neoplasms
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
Neoplasms
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
Neoplasms
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
Neoplasms
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-?B signaling.
Neoplasms
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.
Neoplasms
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
Neoplasms
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
Neoplasms
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
Neoplasms
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.
Neoplasms
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
Neoplasms
SIRT6 inhibits metastasis by suppressing SNAIL expression in nasopharyngeal carcinoma cells.
Neoplasms
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
Neoplasms
SIRT6 inhibits TNF-?-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway.
Neoplasms
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
Neoplasms
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
Neoplasms
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
Neoplasms
SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-?B signaling.
Neoplasms
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.
Neoplasms
SIRT6 overexpression inhibits HIF1? expression and its impact on tumor angiogenesis in lung cancer.
Neoplasms
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
Neoplasms
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
Neoplasms
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
Neoplasms
SIRT6 regulates TNF-? secretion through hydrolysis of long-chain fatty acyl lysine.
Neoplasms
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
Neoplasms
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Neoplasms
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal?regulated kinase signaling pathway.
Neoplasms
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression.
Neoplasms
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Neoplasms
Sirtuin 6 Attenuates Kaposi's Sarcoma-associated herpesvirus (KSHV) Reactivation via Suppressing the Ori-Lyt Activity and Expression of RTA.
Neoplasms
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Neoplasms
Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-?1/Smad3 signaling.
Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Neoplasms
Sirtuin 6 promotes transforming growth factor-?1/H2 O2 /HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Neoplasms
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Neoplasms
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Neoplasms
Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.
Neoplasms
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR).
Neoplasms
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Neoplasms
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.
Neoplasms
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
Neoplasms
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
Neoplasms
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.
Neoplasms
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
Neoplasms
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
Neoplasms
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Neoplasms
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
Neoplasms
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
Neoplasms
The molecular mechanisms associated with PIN7, a protein-protein interaction network of seven pleiotropic proteins.
Neoplasms
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Neoplasms
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Neoplasms
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
Neoplasms
Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis.
Neoplasms
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
Neoplasms
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Neoplasms
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
Neoplasms
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Neoplasms
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Neoplasms
Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability.
Nephrolithiasis
Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Neuralgia
Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel.
Neuroblastoma
Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.
Neurodegenerative Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Neurodegenerative Diseases
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Neurodegenerative Diseases
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
Neuroinflammatory Diseases
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
Nevus, Pigmented
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Non-alcoholic Fatty Liver Disease
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis.
Non-alcoholic Fatty Liver Disease
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
Non-alcoholic Fatty Liver Disease
Pediatric Non-Alcoholic Fatty Liver Disease Is Affected by Genetic Variants Involved in Lifespan/Healthspan.
Obesity
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans.
Obesity
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Obesity
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Obesity
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Obesity
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Obesity
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Obesity
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Obesity
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.
Obesity
SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPK? signaling pathway.
Obesity
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
Obesity
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling.
Obesity
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
Obesity
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.
Obesity
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Obesity
Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
Obesity, Morbid
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.
Obstetric Labor, Premature
SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes.
Osteoarthritis
MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6 : possible involvement in cartilage degradation in osteoarthritis.
Osteoarthritis
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Osteoarthritis
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Osteoarthritis
Overexpression of Sirtuin 6 suppresses cellular senescence and NF-?B mediated inflammatory responses in osteoarthritis development.
Osteoarthritis
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Osteoarthritis
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Osteonecrosis
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Osteoporosis
Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.
Osteoporosis
MiR-128 inhibits the osteogenic differentiation in osteoporosis by down-regulating SIRT6 expression.
Osteoporosis
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor ?.
Osteosarcoma
CK2?/CSNK2A1 Induces Resistance to Doxorubicin through SIRT6-Mediated Activation of the DNA Damage Repair Pathway.
Osteosarcoma
FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.
Osteosarcoma
Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma.
Osteosarcoma
Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma.
Osteosarcoma
MiR-654-5p regulated cell progression and tumor growth through targeting SIRT6 in osteosarcoma.
Osteosarcoma
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
Osteosarcoma
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Ovarian Neoplasms
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
Ovarian Neoplasms
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer.
Ovarian Neoplasms
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
Ovarian Neoplasms
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
Overnutrition
SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPK? signaling pathway.
Overweight
Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients.
Overweight
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Pancreatic Neoplasms
Epigenomic therapies: the potential of targeting SIRT6 for the treatment of pancreatic cancer.
Pancreatic Neoplasms
miR-373 Suppresses Cell Proliferation and Apoptosis via Regulation of SIRT1/PGC-1?/NRF2 Axis in Pancreatic Cancer.
Pancreatic Neoplasms
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Parkinson Disease
Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.
Parkinson Disease
Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.
Parkinsonian Disorders
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Periapical Periodontitis
Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia-induced chemokine (C-C motif) ligand 2 production in osteoblasts.
Periodontitis
Identification of PGN_1123 as the gene encoding lipid A deacylase, an enzyme required for Toll-like receptor 4 evasion, in Porphyromonas gingivalis.
Plasmacytoma
Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6.
Pneumonia
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Polycystic Ovary Syndrome
Serum sirtuin 1 levels in patients with polycystic ovary syndrome.
Prediabetic State
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Progeria
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei.
Prostatic Neoplasms
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics.
Prostatic Neoplasms
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
Prostatic Neoplasms
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
Prostatic Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Prostatic Neoplasms
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
Prostatic Neoplasms
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
protein acetyllysine n-acetyltransferase deficiency
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
A sirtuin link between metabolism and heart disease.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
beta-hydroxyisobutyryl coenzyme A deacylase deficiency: a defect in valine metabolism associated with physical malformations.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Characterization of physiological defects in adult SIRT6-/- mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
ERR? suppression by Sirt6 alleviates cholestatic liver injury and fibrosis.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
FoxO3 transcription factor and Sirt6 deacetylase regulate LDL-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 deficiency culminates in low-turnover osteopenia.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirt6 deficiency impairs corneal epithelial wound healing.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirt6 deficiency results in progression of glomerular injury in the kidney.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 is required for normal retinal function.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPAR?.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin 6 deficiency transcriptionally up-regulates TGF-? signaling and induces fibrosis in mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin 6 is a negative regulator of Fc?RI signaling and anaphylactic responses.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin 6 promotes eosinophil differentiation by activating GATA-1 transcription factor.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin 6: linking longevity with genome and epigenome stability.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking ?-catenin target gene expression.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
The Role of Sirt6 in Obesity and Diabetes.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
[3-Hydroxyisobutyryl-CoA deacylase deficiency]
Proteinuria
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Psoriasis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Psoriasis
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Pulmonary Disease, Chronic Obstructive
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis.
Pulmonary Disease, Chronic Obstructive
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Pulmonary Disease, Chronic Obstructive
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
Pulmonary Disease, Chronic Obstructive
Oxidative stress dependent microRNA-34a activation via PI3K? reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells.
Pulmonary Disease, Chronic Obstructive
Role of sirtuins in chronic obstructive pulmonary disease.
Pulmonary Fibrosis
Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-?1/Smad2 signaling pathway.
Pulpitis
Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70.
Pulpitis
SIRT6 protects against lipopolysaccharide (LPS)-induced apoptosis in human dental pulp cells by deacetylation of Ku70.
Rectal Neoplasms
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
Renal Insufficiency
Calorie Restriction-induced SIRT6 Activation Delays Aging by Suppressing NF-?B Signaling.
Reperfusion Injury
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
Reperfusion Injury
MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway.
Reperfusion Injury
The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking ?-catenin target gene expression.
Retinal Degeneration
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.
Sepsis
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Sepsis
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.
Skin Neoplasms
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
Spinal Cord Injuries
Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury.
Spinal Stenosis
SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patients.
Squamous Cell Carcinoma of Head and Neck
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Squamous Cell Carcinoma of Head and Neck
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Starvation
Formation of D-tyrosyl-tRNATyr accounts for the toxicity of D-tyrosine toward Escherichia coli.
Starvation
SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis.
Stomach Neoplasms
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer.
Stomach Neoplasms
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
Stomach Neoplasms
SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer.
Stroke
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Stroke
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Thyroid Cancer, Papillary
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
Thyroid Cancer, Papillary
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
Thyroid Cancer, Papillary
SIRT6/HIF-1? axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.
Thyroid Cancer, Papillary
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
Thyroid Neoplasms
Long Noncoding RNA CCDC26 Promotes Thyroid Cancer Malignant Progression via miR-422a/EZH2/Sirt6 Axis.
Triple Negative Breast Neoplasms
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Tuberculosis
Studies on the binding of modest modulators of the human enzyme, Sirtuin 6, using STD-NMR.
Urinary Bladder Neoplasms
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Uterine Cervical Neoplasms
DNA repair gene expression is associated with differential prognosis between HPV16 and HPV18 positive cervical cancer patients following radiation therapy.
Vascular Calcification
Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.
Vascular Diseases
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells.
Werner Syndrome
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Whooping Cough
ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins.
Whooping Cough
Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment.
Whooping Cough
Elucidation of linear epitopes of pertussis toxin using overlapping synthetic decapeptides: identification of a human B-cell determinant in the S1 subunit indicative of acute infections.
Whooping Cough
Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate.
Whooping Cough
Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.
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