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Disease on EC 2.3.1.B41 - protein-long-chain fatty-acyl-lysine deacylase (NAD+)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acne Vulgaris
Sirtuin6 inhibits c-triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1/CGRP.
Acute Kidney Injury
Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.
Acute Lung Injury
Sirtuin 6 mitigated LPS-induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2-related factor 2.
Adenocarcinoma
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.
Adenocarcinoma of Lung
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
Adenoviridae Infections
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
Adrenocortical Carcinoma
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-?B signaling.
Alzheimer Disease
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes.
Effect of Colloidal Aqueous Solution of Fullerene (C60) in the Presence of a P-Glycoprotein Inhibitor (Verapamil) on Spatial Memory and Hippocampal Expression of Sirtuin6, SELADIN1, and AQP1 Genes in a Rat Model of Alzheimer's Disease.
Efficacy and safety of NAD+ ADP-ribosyltransferase 1 agonist versus Donepezil in elderly Chinese patients with Alzheimer disease: A novel target for effective therapy.
Emerging Roles of Sirtuin 6 in Alzheimer's Disease.
Neuroprotective Functions for the Histone Deacetylase SIRT6.
SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis.
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Anaphylaxis
Sirtuin 6 is a negative regulator of Fc?RI signaling and anaphylactic responses.
Arthritis
Emerging roles of SIRT6 in human diseases and its modulators.
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Arthritis, Experimental
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.
Arthritis, Rheumatoid
Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6.
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
Asthma
Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-?1/Smad3 pathway and c-Jun in asthma models.
Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma.
Atherosclerosis
Correction to: SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis.
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.
Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1? and reactive oxygen species.
SIRT6 protects against endothelial dysfunction and atherosclerosis in mice.
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis.
SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.
SIRT6 slows VSMC senescence and atherogenesis.
Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells.
Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction.
Sirtuin 6: a potential therapeutic target for cardiovascular diseases.
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.
Autoimmune Diseases
Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease.
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Bone Diseases, Metabolic
Evidence for excessive osteoclast activation in SIRT6 null mice.
Loss of Sirtuin 6 in osteoblast lineage cells activates osteoclasts, resulting in osteopenia.
Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation.
SIRT6 deficiency culminates in low-turnover osteopenia.
Bone Resorption
Evidence for excessive osteoclast activation in SIRT6 null mice.
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
SIRT6 deficiency culminates in low-turnover osteopenia.
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor ?.
Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption.
Brain Diseases
Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction.
Brain Injuries
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells.
Brain Ischemia
Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage.
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway.
Breast Neoplasms
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
High-throughput screening of Sirtuin family of genes in breast cancer.
Icariin-induced inhibition of SIRT6/NF-?B triggers redox mediated apoptosis and enhances anti-tumor immunity in TNBC.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells.
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling.
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
[Function of SIRT6 in tumor initiation and progression].
Carcinogenesis
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma.
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
miR-34a inhibits tumorigenesis of NSCLC via targeting SIRT6.
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
SIRT1, a promising regulator of bone homeostasis.
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
SIRT3 Expression as a Biomarker for Better Prognosis in Gastric Cancer.
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-?B signaling.
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
Sirt6 is required for spermatogenesis in mice.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
Sirtuins and SIRT6 in Carcinogenesis and in Diet.
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
The complex role of SIRT6 in carcinogenesis.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
The sirtuin 6: An overture in skin cancer.
The Two-Faced Role of SIRT6 in Cancer.
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
[Function of SIRT6 in tumor initiation and progression].
Carcinoma
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells.
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
The sirtuin 6: An overture in skin cancer.
Carcinoma, Basal Cell
The sirtuin 6: An overture in skin cancer.
Carcinoma, Ductal
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Carcinoma, Hepatocellular
Coordination of FOXA2 and SIRT6 suppresses the hepatocellular carcinoma progression through ZEB2 inhibition.
Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.
Identification of a cellularly active SIRT6 allosteric activator.
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma.
Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells.
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression.
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway.
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal?regulated kinase signaling pathway.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 promotes transforming growth factor-?1/H2 O2 /HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth.
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Carcinoma, Intraductal, Noninfiltrating
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
Carcinoma, Non-Small-Cell Lung
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines.
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Carcinoma, Renal Cell
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Carcinoma, Squamous Cell
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
The sirtuin 6: An overture in skin cancer.
Cardiomegaly
Deubiquitinase Ubiquitin-Specific Protease 10 Deficiency Regulates Sirt6 signaling and Exacerbates Cardiac Hypertrophy.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.
SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity.
Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-?B-dependent transcriptional activity.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.
The role of sirtuins in cardiac disease.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Cardiomyopathies
Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy.
Cardiomyopathy, Hypertrophic
A sirtuin link between metabolism and heart disease.
Cardiotoxicity
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a.
Cardiovascular Diseases
Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice.
Emerging roles of SIRT6 in human diseases and its modulators.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.
Sequence Variants of SIRT6 Gene Promoter in Myocardial Infarction.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases.
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.
Sirtuin 6: a potential therapeutic target for cardiovascular diseases.
Sirtuins and Insulin Resistance.
Cholera
A note on the predicted secondary structures of the active chains of cholera and diphtheria toxins.
ADP-ribosyl transferase activity of cholera toxin polypeptide A1 and the effect of limited trypsinolysis.
ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins.
Cholestasis
ERR? suppression by Sirt6 alleviates cholestatic liver injury and fibrosis.
Colitis
Interferon-? inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.
Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice.
Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice.
Colonic Neoplasms
Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities.
Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.
FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
PKC? Phosphorylates SIRT6 to Mediate Fatty Acid ?-Oxidation in Colon Cancer Cells.
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
Colorectal Neoplasms
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A.
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer.
[Coronavirus disease (COVID-19) and sirtuins].
Congenital Abnormalities
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Corneal Injuries
Emerging roles of SIRT6 in human diseases and its modulators.
Corneal Opacity
Sirt6 deficiency impairs corneal epithelial wound healing.
Coronary Artery Disease
Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
COVID-19
[Coronavirus disease (COVID-19) and sirtuins].
Cystic Fibrosis
The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.
Dengue
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-?B p65.
Dermatitis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Dermatitis, Atopic
A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis.
A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.
Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis.
The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
Diabetes Complications
New insight in molecular mechanisms regulating SIRT6 expression in diabetes: Hyperglycaemia effects on SIRT6 DNA methylation.
Diabetes Mellitus
Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: An immunohistochemical study.
Sirtuins and Insulin Resistance.
Diabetes Mellitus, Type 2
Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuins and Insulin Resistance.
Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of sodium-glucose co-transporter2 inhibitor treatment.
Diabetic Cardiomyopathies
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Diabetic Nephropathies
FOXO3a Protects against Kidney Injury in Type II Diabetic Nephropathy by Promoting Sirt6 Expression and Inhibiting Smad3 Acetylation.
Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Diabetic Retinopathy
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.
Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.
Diphtheria
A note on the predicted secondary structures of the active chains of cholera and diphtheria toxins.
An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.
Genetic assembly and selective toxicity of diphtheria-toxin-related polypeptide hormone fusion proteins.
Mapping the enzymatic active site of Pseudomonas aeruginosa exotoxin A.
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks.
Dyslipidemias
SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.
Encephalomyelitis
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration.
Encephalomyelitis, Autoimmune, Experimental
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration.
Endometrial Neoplasms
Molecular markers of endometrial carcinoma detected in uterine aspirates.
Putative tumor suppression function of SIRT6 in endometrial cancer.
Endometriosis
Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis?
Esophageal Neoplasms
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Fanconi Anemia
The basal and the mutagen-induced levels of ADP-ribosyl transferase activity are not modified in Fanconi's anemia cells.
Farber Lipogranulomatosis
Leukocyte and plasma N-laurylsphingosine deacylase (ceramidase) in Farber disease.
The synthetic pathway for glucosylsphingosine in cultured fibroblasts.
Fatty Liver
Emerging roles of SIRT6 in human diseases and its modulators.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Sirtuins and Insulin Resistance.
The Role of Sirt6 in Obesity and Diabetes.
Fetal Death
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Fetal Diseases
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Gastrointestinal Neoplasms
Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysis.
Glioblastoma
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells.
Glioma
Histone deacetylase SIRT6 inhibits glioma cell growth through down-regulating NOTCH3 expression.
Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation.
MST1 suppresses viability and promotes apoptosis of glioma cells via upregulating SIRT6 expression.
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells.
Glucose Intolerance
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans.
Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis.
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Heart Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Chromatin and beyond: the multitasking roles for SIRT6.
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling.
Heart Failure
A sirtuin link between metabolism and heart disease.
Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Sirtuin 6: a potential therapeutic target for cardiovascular diseases.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Hematologic Neoplasms
Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.
Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.
Hematuria
Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.
Hepatitis B
SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors ?.
Hepatitis, Alcoholic
The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice.
Hodgkin Disease
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Huntington Disease
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Hypercholesterolemia
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6.
Hyperglycemia
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs.
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis.
Hypersensitivity
Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction.
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
Hypertension
Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling.
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling.
Hypertrophy, Left Ventricular
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Hypoglycemia
A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
The Role of Sirt6 in Obesity and Diabetes.
Idiopathic Pulmonary Fibrosis
Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-?1/Smad3 signaling.
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-?1/Smad2 and nuclear factor-?B signaling pathways in human fetal lung fibroblasts.
Infarction, Middle Cerebral Artery
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Infections
Antimalarial activity of inhibitors of ADP-ribosyl transferase against Plasmodium yoelii infection in mice. 1. Preliminary data.
Bst1 is required for Candida albicans infecting host via facilitating cell wall anchorage of Glycosylphosphatidyl inositol anchored proteins.
FOXO3a?SIRT6 axis suppresses aerobic glycolysis in melanoma.
IRF5 regulates airway macrophage metabolic responses.
Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-?B p65.
Sirtuin 6 Attenuates Kaposi's Sarcoma-associated herpesvirus (KSHV) Reactivation via Suppressing the Ori-Lyt Activity and Expression of RTA.
Targeting of the actin cytoskeleton during infection by Salmonella strains.
Infertility
SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity.
Influenza, Human
IRF5 regulates airway macrophage metabolic responses.
Insulin Resistance
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans.
Administration of kynurenic acid reduces hyperlipidemia-induced inflammation and insulin resistance in skeletal muscle and adipocytes.
Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental?
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.
SIRT6 as a potential target for treating insulin resistance.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
Sirt6 deletion in hepatocytes increases insulin sensitivity of female mice by enhancing ER? expression.
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Sirtuins and Insulin Resistance.
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
The Role of Sirt6 in Obesity and Diabetes.
The Roles of Mitochondrial SIRT4 in Cellular Metabolism.
Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.
Intervertebral Disc Degeneration
Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.
Sirtuin 6 prevents matrix degradation through inhibition of the NF-?B pathway in intervertebral disc degeneration.
Intestinal Volvulus
Detection of adenosine diphosphate-ribosyl transferase activity in the filarial worm, Onchocerca volvulus.
Ischemic Stroke
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.
Kidney Diseases
Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Sirtuins in Renal Health and Disease.
Kidney Neoplasms
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Leukemia
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Author Correction: Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.
Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.
Leukemia, Myeloid, Acute
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.
MYC upregulated LINC00319 promotes human acute myeloid leukemia (AML) cells growth through stabilizing SIRT6.
SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.
Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition.
Liver Cirrhosis
Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells.
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-?1/Smad3 pathway and c-Jun in asthma models.
Liver Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Sirtuins and Insulin Resistance.
The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
Liver Neoplasms
Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
[Function of SIRT6 in tumor initiation and progression].
Lung Injury
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Lung Neoplasms
?-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Influence of SIRT6 regulation of cellular glycometabolism on radiosensitivity of non-small-cell lung cancer A549 cells.
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.
MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines.
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6 overexpression inhibits HIF1? expression and its impact on tumor angiogenesis in lung cancer.
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
[Function of SIRT6 in tumor initiation and progression].
Lymphatic Metastasis
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Lymphoma
The effects of benzamide ADP-ribosyl transferase inhibitors on cell survival and DNA strand-break repair in irradiated mammalian cells.
Lymphoma, B-Cell
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
Sirtuin 6 protects the heart from hypoxic damage.
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Lymphoma, Large B-Cell, Diffuse
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
Medulloblastoma
RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein.
Melanoma
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo.
Selection Signatures Analysis Reveals Genes Associated with High-Altitude Adaptation in Tibetan Goats from Nagqu, Tibet.
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling.
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
The sirtuin 6: An overture in skin cancer.
Metabolic Diseases
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
SIRT6 protects against pathological damage caused by diet-induced obesity.
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPAR?.
SIRT6: Novel Mechanisms and Links to Aging and Disease.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuins as endogenous regulators of lung fibrosis: A current perspective.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Metabolic Syndrome
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
SIRT6 protects against pathological damage caused by diet-induced obesity.
Multiple Myeloma
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Muscular Atrophy
Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
Myocardial Infarction
Metformin Therapy Effects on the Expression of Sodium-Glucose Cotransporter 2, Leptin, and SIRT6 Levels in Pericoronary Fat Excised from Pre-Diabetic Patients with Acute Myocardial Infarction.
Sequence Variants of SIRT6 Gene Promoter in Myocardial Infarction.
Nasal Polyps
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Sirtuin 6 modulates hypoxia-induced autophagy in nasal polyp fibroblasts via inhibition of glycolysis.
Nasopharyngeal Carcinoma
SIRT6 inhibits metastasis by suppressing SNAIL expression in nasopharyngeal carcinoma cells.
SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-?B signaling.
Neoplasm Metastasis
Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer.
Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysis.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.
SIRT6 inhibits metastasis by suppressing SNAIL expression in nasopharyngeal carcinoma cells.
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
SIRT6 Loss Promotes PDAC Progression by Epigenetic Induction of LIN28B.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
Neoplasms
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes.
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
A miR-34a-SIRT6 axis in the squamous cell differentiation network.
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response.
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.
C. elegans sirtuin SIR-2.4 and its mammalian homolog SIRT6 in stress response.
Changes in the response of the RIF-1 tumour to melphalan in vivo induced by inhibitors of nuclear ADP-ribosyl transferase.
Chemical enhancement of cisplatin cytotoxicity in a human ovarian and cervical cancer cell line.
Chromatin and beyond: the multitasking roles for SIRT6.
CK2?/CSNK2A1 Induces Resistance to Doxorubicin through SIRT6-Mediated Activation of the DNA Damage Repair Pathway.
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes.
Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-? Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Discovery of novel and selective SIRT6 inhibitors.
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells.
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.
Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities.
Emerging roles of SIRT6 in human diseases and its modulators.
Emerging Therapeutic Potential of SIRT6 Modulators.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
Expression of SIRT2 and SIRT6 in retinoblastoma.
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
FOXO3a?SIRT6 axis suppresses aerobic glycolysis in melanoma.
Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice.
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Identification of a cellularly active SIRT6 allosteric activator.
Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.
In silico screening of small molecule modulators and their binding studies against human sirtuin-6 protein.
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics.
Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Inhibitors of ADP-ribosyl transferase suppress the mitogenic actions exerted by tumour promoters, but not those evoked by peptide mitogens, in primary neonatal rat hepatocytes.
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.
Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products.
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators.
MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
miR-34a inhibits tumorigenesis of NSCLC via targeting SIRT6.
MiR-654-5p regulated cell progression and tumor growth through targeting SIRT6 in osteosarcoma.
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.
Multiple Regulatory Layers of SREBP1/2 by SIRT6.
Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Novel tools to analyze the function of Salmonella effectors show that SvpB ectopic expression induces cell cycle arrest in tumor cells.
NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma.
Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.
Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin.
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
PKC? Phosphorylates SIRT6 to Mediate Fatty Acid ?-Oxidation in Colon Cancer Cells.
Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation.
Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysis.
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Putative tumor suppression function of SIRT6 in endometrial cancer.
Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence.
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
Scientometric Analysis of SIRT6 Studies.
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells.
Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines.
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-?B signaling.
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients.
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice.
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
SIRT6 inhibits metastasis by suppressing SNAIL expression in nasopharyngeal carcinoma cells.
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
SIRT6 inhibits TNF-?-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-?B signaling.
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.
SIRT6 overexpression inhibits HIF1? expression and its impact on tumor angiogenesis in lung cancer.
SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinoma via BCL2-associated X protein-dependent apoptotic pathway.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
SIRT6 puts cancer metabolism in the driver's seat.
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
SIRT6 regulates TNF-? secretion through hydrolysis of long-chain fatty acyl lysine.
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation.
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal?regulated kinase signaling pathway.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression.
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.
SIRT6: A master epigenetic gatekeeper of glucose metabolism.
SIRT6: A Promising Target for Cancer Prevention and Therapy.
SIRT6: Novel Mechanisms and Links to Aging and Disease.
Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers.
Sirtuin 6 Attenuates Kaposi's Sarcoma-associated herpesvirus (KSHV) Reactivation via Suppressing the Ori-Lyt Activity and Expression of RTA.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling.
Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-?1/Smad3 signaling.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin 6 promotes transforming growth factor-?1/H2 O2 /HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B-cell lymphoma 2.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.
Sirtuins and SIRT6 in Carcinogenesis and in Diet.
Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™).
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
Targeting aberrant cancer metabolism - The role of sirtuins.
The complex role of SIRT6 in carcinogenesis.
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.
The dual role of sirtuins in cancer.
The expression levels of the sirtuins in patients with BCC.
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The molecular mechanisms associated with PIN7, a protein-protein interaction network of seven pleiotropic proteins.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer.
The role of SIRT6 in tumors.
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
The sirtuin 6: An overture in skin cancer.
The Two-Faced Role of SIRT6 in Cancer.
Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis.
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability.
[Coronavirus disease (COVID-19) and sirtuins].
[Effects of SIRT6 in cardiovascular, cancer and metabolic diseases].
[Function of SIRT6 in tumor initiation and progression].
Nephrolithiasis
Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Neuralgia
Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel.
Neuroblastoma
Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation.
Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.
Neurodegenerative Diseases
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Emerging roles of SIRT6 in human diseases and its modulators.
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
Neuroinflammatory Diseases
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
Nevus, Pigmented
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.
Non-alcoholic Fatty Liver Disease
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis.
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
Pediatric Non-Alcoholic Fatty Liver Disease Is Affected by Genetic Variants Involved in Lifespan/Healthspan.
Obesity
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans.
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Chromatin and beyond: the multitasking roles for SIRT6.
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance.
Multiple Regulatory Layers of SREBP1/2 by SIRT6.
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.
SIRT6 as a potential target for treating insulin resistance.
SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPK? signaling pathway.
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity.
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling.
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
SIRT6 protects against pathological damage caused by diet-induced obesity.
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.
Sirtuin 6, a possible therapeutic target for type 2 diabetes.
Sirtuins and Insulin Resistance.
The complex role of SIRT6 in carcinogenesis.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
The Role of Sirt6 in Obesity and Diabetes.
Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.
Obesity, Morbid
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.
Obstetric Labor, Premature
SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes.
Osteoarthritis
MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6 : possible involvement in cartilage degradation in osteoarthritis.
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Osteoarthritis: SIRT6 prevents chondrocyte senescence and DNA damage.
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Overexpression of Sirtuin 6 suppresses cellular senescence and NF-?B mediated inflammatory responses in osteoarthritis development.
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Osteonecrosis
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling.
Osteoporosis
Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.
MiR-128 inhibits the osteogenic differentiation in osteoporosis by down-regulating SIRT6 expression.
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
SIRT6 deficiency culminates in low-turnover osteopenia.
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor ?.
Osteosarcoma
CK2?/CSNK2A1 Induces Resistance to Doxorubicin through SIRT6-Mediated Activation of the DNA Damage Repair Pathway.
FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.
Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma.
Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma.
MiR-654-5p regulated cell progression and tumor growth through targeting SIRT6 in osteosarcoma.
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.
Ovarian Neoplasms
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer.
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via ?-Catenin-Mediated Epithelial to Mesenchymal Transition.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
Overnutrition
SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPK? signaling pathway.
The Role of Sirt6 in Obesity and Diabetes.
Overweight
Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients.
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Pancreatic Neoplasms
Epigenomic therapies: the potential of targeting SIRT6 for the treatment of pancreatic cancer.
miR-373 Suppresses Cell Proliferation and Apoptosis via Regulation of SIRT1/PGC-1?/NRF2 Axis in Pancreatic Cancer.
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Paralysis
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
Parkinson Disease
Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.
Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.
Parkinsonian Disorders
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Periapical Periodontitis
Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia-induced chemokine (C-C motif) ligand 2 production in osteoblasts.
Periodontitis
Identification of PGN_1123 as the gene encoding lipid A deacylase, an enzyme required for Toll-like receptor 4 evasion, in Porphyromonas gingivalis.
Plasmacytoma
Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6.
Pneumonia
Experimental studies on the protective effects of the overexpression of lentivirus-mediated sirtuin 6 on radiation-induced lung injury.
Polycystic Ovary Syndrome
Serum sirtuin 1 levels in patients with polycystic ovary syndrome.
Prediabetic State
SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus.
Progeria
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei.
Prostatic Neoplasms
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics.
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
protein acetyllysine n-acetyltransferase deficiency
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.
A sirtuin link between metabolism and heart disease.
beta-hydroxyisobutyryl coenzyme A deacylase deficiency: a defect in valine metabolism associated with physical malformations.
Characterization of physiological defects in adult SIRT6-/- mice.
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.
ERR? suppression by Sirt6 alleviates cholestatic liver injury and fibrosis.
FoxO3 transcription factor and Sirt6 deacetylase regulate LDL-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting.
Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes.
Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium.
Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype.
Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes.
SIRT6 deficiency culminates in low-turnover osteopenia.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Sirt6 deficiency impairs corneal epithelial wound healing.
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
Sirt6 deficiency results in progression of glomerular injury in the kidney.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling.
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
SIRT6 is required for normal retinal function.
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPAR?.
SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity.
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.
Sirtuin 6 deficiency transcriptionally up-regulates TGF-? signaling and induces fibrosis in mice.
Sirtuin 6 is a negative regulator of Fc?RI signaling and anaphylactic responses.
Sirtuin 6 promotes eosinophil differentiation by activating GATA-1 transcription factor.
Sirtuin 6: linking longevity with genome and epigenome stability.
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.
The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking ?-catenin target gene expression.
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
The Role of Sirt6 in Obesity and Diabetes.
Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.
[3-Hydroxyisobutyryl-CoA deacylase deficiency]
Proteinuria
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Sirt6 deficiency results in progression of glomerular injury in the kidney.
Psoriasis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Pulmonary Disease, Chronic Obstructive
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis.
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
Oxidative stress dependent microRNA-34a activation via PI3K? reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells.
Role of sirtuins in chronic obstructive pulmonary disease.
Senotherapy: A New Horizon for COPD Therapy.
Pulmonary Fibrosis
Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-?1/Smad2 signaling pathway.
Pulpitis
Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70.
Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel.
SIRT6 protects against lipopolysaccharide (LPS)-induced apoptosis in human dental pulp cells by deacetylation of Ku70.
Rectal Neoplasms
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
Renal Insufficiency
Calorie Restriction-induced SIRT6 Activation Delays Aging by Suppressing NF-?B Signaling.
Reperfusion Injury
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.
MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway.
The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking ?-catenin target gene expression.
Retinal Degeneration
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.
Role of Sirtuins in Retinal Function Under Basal Conditions.
Retinoblastoma
Expression of SIRT2 and SIRT6 in retinoblastoma.
Sirt1 increases skeletal muscle precursor cell proliferation.
Sarcoma, Kaposi
[Coronavirus disease (COVID-19) and sirtuins].
Sepsis
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
Skin Diseases
The sirtuin 6: An overture in skin cancer.
Skin Neoplasms
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
The sirtuin 6: An overture in skin cancer.
Spinal Cord Injuries
Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury.
Spinal Stenosis
SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patients.
Squamous Cell Carcinoma of Head and Neck
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
Starvation
Effect of starvation on the N-acetylglutamate system of rat liver.
Formation of D-tyrosyl-tRNATyr accounts for the toxicity of D-tyrosine toward Escherichia coli.
SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis.
Stomach Neoplasms
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer.
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer.
Stroke
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Thyroid Cancer, Papillary
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl?1 pathway.
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
SIRT6/HIF-1? axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
Thyroid Neoplasms
Long Noncoding RNA CCDC26 Promotes Thyroid Cancer Malignant Progression via miR-422a/EZH2/Sirt6 Axis.
Triple Negative Breast Neoplasms
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Tuberculosis
Studies on the binding of modest modulators of the human enzyme, Sirtuin 6, using STD-NMR.
Urinary Bladder Neoplasms
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder.
Uterine Cervical Neoplasms
DNA repair gene expression is associated with differential prognosis between HPV16 and HPV18 positive cervical cancer patients following radiation therapy.
Vascular Calcification
Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.
Vascular Diseases
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells.
Virus Diseases
Emerging roles of SIRT6 in human diseases and its modulators.
IRF5 regulates airway macrophage metabolic responses.
Werner Syndrome
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Whooping Cough
ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins.
Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment.
Elucidation of linear epitopes of pertussis toxin using overlapping synthetic decapeptides: identification of a human B-cell determinant in the S1 subunit indicative of acute infections.
G(z) signaling: emerging divergence from G(i) signaling.
Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate.
Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.