Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 2.3.1.32 - lysine N-acetyltransferase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.
p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene.
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
Adenocarcinoma of Lung
Subcellular localization of ?-arrestin1 and its prognostic value in lung adenocarcinoma.
Adenoviridae Infections
Stimulation of p300-mediated transcription by the kinase MEKK1.
Alzheimer Disease
Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces ?-Secretase (BACE1) Levels and A? Generation.
Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism.
Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease.
Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.
The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway.
Ataxia Telangiectasia
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.
Atherosclerosis
Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease.
Autoimmune Diseases
Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease.
Breast Neoplasms
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGF?-mediated breast cancer cell migration and invasion.
CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50.
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer.
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.
Erratum to: A novel function for p21 Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGF?-mediated breast cancer cell migration and invasion.
Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression.
p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Carcinogenesis
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs.
P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma.
p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis.
Carcinoma
Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator.
Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.
Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.
[Effect of mutation in the p300 transcription coactivator on transcriptional response and cell proliferation of human carcinoma cell lines]
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
Carcinoma, Ductal
Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator.
Carcinoma, Hepatocellular
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism.
Carcinoma, Squamous Cell
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
Cardiomegaly
Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis.
Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach.
Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300.
Choriocarcinoma
Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.
Colitis
C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome.
Colonic Neoplasms
Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators.
The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma.
Colorectal Neoplasms
5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer.
Acetylation-dependent function of human single-stranded DNA binding protein 1.
Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT.
Contracture
Protective effect of ?-lipoic acid against radiation-induced fibrosis in mice.
Cysts
Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes.
Diabetes Mellitus, Type 2
Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling.
Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity.
Endometrial Hyperplasia
Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression.
Endometrial Neoplasms
Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression.
Glioma
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1? interaction with co-factors p300/CBP.
EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.
Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site.
Heart Septal Defects, Ventricular
Down-regulation of EBAF in the heart with ventricular septal defects and its regulation by histone acetyltransferase p300 and transcription factors smad2 and cited2.
Hematologic Neoplasms
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.
Hepatitis B
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Hepatitis C
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity.
Hepatitis E
The hepatitis E virus ORF3 protein stabilizes HIF-1alpha and enhances HIF-1-mediated transcriptional activity through p300/CBP.
Herpes Simplex
Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3.
Hypercholesterolemia
Piceatannol reduces resistance to statins in hypercholesterolemia by reducing PCSK9 expression through p300 acetyltransferase inhibition.
Hyperglycemia
Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling.
Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.
Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycemic conditions.
Infections
A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase.
Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.
Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity.
Direct suppression of Stat1 function during adenoviral infection.
Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling.
Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo.
Influenza, Human
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Insulin Resistance
Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.
Iron Overload
Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway.
Leukemia
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ.
BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.
P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP.
Leukemia, Erythroblastic, Acute
P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.
Leukemia, Myeloid
Acetylation of lysine564 adjacent to the CTBP-binding motif in EVI1 is crucial for transcriptional activation of GATA2.
Leukemia, Myeloid, Acute
MAP30 inhibits autophagy through enhancing acetyltransferase p300 and induces apoptosis in acute myeloid leukemia cells.
Leukemia, T-Cell
An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ.
Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.
p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function.
Tax abolishes histone H1 repression of p300 acetyltransferase activity at the human T-cell leukemia virus type 1 promoter.
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP.
Liver Cirrhosis
p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis.
Liver Diseases
p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis.
Lung Neoplasms
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300.
C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe.
Snail acetylation by histone acetyltransferase p300 in lung cancer.
TGF-?1-induced epithelial-mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in Human A549 lung cancer cells.
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
[p300/CBP and Lung Cancer.]
Lupus Nephritis
Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor ? mRNA, glucocorticoid receptor ? mRNA and P300/CBP protein in lupus nephritis mice.
[Effect of artemisinin on the expressions of GRalpha mRNA, GRbeta mRNA and P300/CBP protein in lupus nephritis mice].
Lymphatic Metastasis
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGF?-mediated breast cancer cell migration and invasion.
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
Lymphoma
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K? inhibitor idelalisib.
Lymphoma, B-Cell
Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.
Lymphoma, Large B-Cell, Diffuse
Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.
Lymphoma, Mantle-Cell
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K? inhibitor idelalisib.
Melanoma
A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.
CBP/p300 as a co-factor for the Microphthalmia transcription factor.
MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.
Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP.
Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.
Microphthalmos
Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia.
Multiple Myeloma
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
Neoplasm Metastasis
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGF?-mediated breast cancer cell migration and invasion.
Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma.
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300.
Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-?1 signaling pathways.
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
Neoplasms
A novel function of novobiocin: disrupting the interaction of HIF 1? and p300/CBP through direct binding to the HIF1? C-terminal activation domain.
Acetylation control of the retinoblastoma tumour-suppressor protein.
Acetylation-dependent function of human single-stranded DNA binding protein 1.
Activation of NF-?B and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation.
Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.
Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.
Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor Aggressiveness.
Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Autoacetylation Induced Specific Structural Changes in Histone Acetyltransferase Domain of p300: Probed by Surface Enhanced Raman Spectroscopy.
Binding and modulation of p53 by p300/CBP coactivators.
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Cholecystokinin attenuates radiation-induced lung cancer cell apoptosis by modulating p53 gene transcription.
CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP.
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Curcumin is an inhibitor of p300 histone acetylatransferase.
Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets.
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP.
Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease.
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.
Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator.
Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-?1 signaling pathways.
Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.
Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.
Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.
Inhibition of the HIF1?-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).
Insights from molecular dynamics simulations and steered molecular dynamics simulations to exploit new trends of the interaction between HIF-1? and p300.
Latent viruses can cause disease by disrupting the competition for the limiting factor p300/CBP.
Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.
Nuclear factor I-mediated repression of the mouse mammary tumor virus promoter is abrogated by the coactivators p300/CBP and SRC-1.
P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma.
p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells.
p300/CBP and cancer.
p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer.
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K? inhibitor idelalisib.
p300/CBP proteins: HATs for transcriptional bridges and scaffolds.
p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response.
p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.
PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis.
Polyamine-mediated regulation of protein acetylation in murine skin and tumors.
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein.
Regulation of the p53 homolog p73 by adenoviral oncogene E1A.
Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells.
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.
Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues.
Synthesis and Biological Evaluation of Spirocyclic Chromane Derivatives as a Potential Treatment of Prostate Cancer.
Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP.
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism.
The p300/CBP family: integrating signals with transcription factors and chromatin.
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease.
Toppling the HAT to Treat Lethal Prostate Cancer.
[Expression and significance of TSG101, P21 and P300/CBP in squamous cell carcinoma and adenocarcinoma of the lung.]
Neuralgia
Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model.
Neurodegenerative Diseases
Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.
The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease.
Obesity
Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling.
Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.
Osteosarcoma
Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma.
Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells.
The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells.
Pituitary Neoplasms
Histone acetyltransferase p300 regulates the expression of human pituitary tumor transforming gene (hPTTG).
Pneumonia
Study of insect succession and rate of decomposition on a partially burned pig carcass in an oil palm plantation in Malaysia.
Prostatic Neoplasms
Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region.
Androgen axis in prostate cancer.
p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis.
P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth.
p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer.
Studies on Steroid Receptor Coactivators in Prostate Cancer.
Targeting p300/CBP axis in lethal prostate cancer.
Toppling the HAT to Treat Lethal Prostate Cancer.
Respiratory Distress Syndrome
Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.
Retinoblastoma
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
Acetylation control of the retinoblastoma tumour-suppressor protein.
Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.
Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A.
Gene and protein expression profiling during differentiation of neuroblastoma cells triggered by 13-cis retinoic acid.
Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.
Phosphate is a specific signal for induction of osteopontin gene expression.
Recruitment of TRRAP required for oncogenic transformation by E1A.
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.
Rhabdomyosarcoma, Alveolar
P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma.
Sarcoma, Kaposi
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Spinocerebellar Ataxias
Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin.
Starvation
Autophagy regulation by acetylation-implications for neurodegenerative diseases.
Stomach Neoplasms
Histone acetyltransferase p300/CBP inhibitor C646 blocks the survival and invasion pathways of gastric cancer cell lines.
Tauopathies
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
Urinary Bladder Neoplasms
p300 mediates cellular resistance to doxorubicin in bladder cancer.
Virus Diseases
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients.
Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.
The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease.