Information on EC 2.3.1.266 - [ribosomal protein S18]-alanine N-acetyltransferase

for references in articles please use BRENDA:EC2.3.1.266
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
2.3.1.266
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RECOMMENDED NAME
GeneOntology No.
[ribosomal protein S18]-alanine N-acetyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal L-alanyl-[S18 protein of 30S ribosome] = CoA + an N-terminal N-acetyl-L-alanyl-[S18 protein of 30S ribosome]
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:N-terminal L-alanyl-[S18 protein of 30S ribosome] N-acetyltransferase
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an N-terminal L-alanyl-[L-A virus major coat protein]
CoA + an N-terminal N-acetyl-L-alanyl-[L-A virus major coat protein]
show the reaction diagram
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?
acetyl-CoA + an N-terminal L-alanyl-[S18 protein of 30S ribosome]
CoA + an N-terminal N-acetyl-L-alanyl-[S18 protein of 30S ribosome]
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an N-terminal L-alanyl-[L-A virus major coat protein]
CoA + an N-terminal N-acetyl-L-alanyl-[L-A virus major coat protein]
show the reaction diagram
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-
?
acetyl-CoA + an N-terminal L-alanyl-[S18 protein of 30S ribosome]
CoA + an N-terminal N-acetyl-L-alanyl-[S18 protein of 30S ribosome]
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CoA-S-acetyl-ARYFRR
linearly competitive against acetyl-CoA and linearly noncompetitive against S18 protein(1-6)
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0041
CoA-S-acetyl-ARYFRR
at pH 7.3 and 25°C
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PDB
SCOP
CATH
ORGANISM
UNIPROT
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 16000, SDS-PAGE; x * 18232, calculated from amino acid sequence
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
in complex with CoA, acetyl-CoA, and a CoA-S-acetyl-ARYFRR bisubstrate inhibitor, vapor diffusion method, using
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni HiTrap column chromatography
Sepharose column chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli JM109 cells
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expressed in Escherichia coli Rosetta2 (DE3) pLysS cells
Show AA Sequence (7455 entries)
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