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Information on EC 2.3.1.255 - N-terminal amino-acid Nalpha-acetyltransferase NatA

for references in articles please use BRENDA:EC2.3.1.255
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EC Tree
IUBMB Comments
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
hide(3 overall reactions are displayed. Show all (6)>>)
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an N-terminal-glycyl-[protein]
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an N-terminal-Nalpha-acetyl-glycyl-[protein]
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an N-terminal-L-alanyl-[protein]
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an N-terminal-Nalpha-acetyl-L-alanyl-[protein]
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an N-terminal-L-seryl-[protein]
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an N-terminal-Nalpha-acetyl-L-seryl-[protein]
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Synonyms
naa15, arrest-defective protein 1, n-alpha-acetyltransferase 10, naa10/ard1, nata nalpha-terminal acetyltransferase, n-terminal protein acetyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
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(1)
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acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
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(2)
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acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
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(5)
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acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
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(3)
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acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
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(6)
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acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
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(4)
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PATHWAY SOURCE
PATHWAYS
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