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Information on EC 2.3.1.219 - demethoxycurcumin synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.219 demethoxycurcumin synthase
IUBMB Comments
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well .
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The expected taxonomic range for this enzyme is: Curcuma longa
Synonyms
curcumin synthase, CURS, CURS1, CURS2, CURS3, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2
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4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2
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