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Information on EC 2.3.1.194 - acetoacetyl-CoA synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.194 acetoacetyl-CoA synthase
IUBMB Comments
The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway. Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
npht7, thiolase superfamily acetoacetyl-coa synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2
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