show all | hide all No of entries

Information on EC 2.3.1.181 - lipoyl(octanoyl) transferase

for references in articles please use BRENDA:EC2.3.1.181
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the true substrate . The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues).
Specify your search results
Select one or more organisms in this record:
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
lipoyltransferase, lipb octanoyltransferase, lipoyl(octanoyl)transferase, lip2p2, octanoyltransferase lipm, lipoyl (octanoyl)-acyl carrier protein:protein transferase, octanoyl (lipoyl) n-octanoyl (lipoyl) transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an octanoyl-[acyl-carrier protein] + a protein = a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
show the reaction diagram
Select items on the left to see more content.