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Information on EC 2.3.1.161 - lovastatin nonaketide synthase

for references in articles please use BRENDA:EC2.3.1.161
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EC Tree
IUBMB Comments
This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. The PKS catalyses many of the chain building reactions of EC 2.3.1.85, fatty-acid synthase, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.
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Word Map
The expected taxonomic range for this enzyme is: Aspergillus terreus
Reaction Schemes
9
+
11
+
10
+
+
holo-[lovastatin nonaketide synthase]
=
dihydromonacolin L-[lovastatin nonaketide synthase]
+
9
+
9
+
11
+
+
6
Synonyms
LNKS, lovastatin nonaketide synthase, LovB, synthase, lovastatin nonaketide, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
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