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Information on EC - glycerophospholipid arachidonoyl-transferase (CoA-independent)

for references in articles please use BRENDA:EC2.3.1.147
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IUBMB Comments
Catalyses the transfer of arachidonate and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC glycerophospholipid acyltransferase (CoA-dependent) in not requiring CoA and in its specificity for poly-unsaturated acyl groups.
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Word Map
  • arachidonic
  • platelet-activating
  • paf
  • transacylation
  • plasmalogens
  • coa-dependent
  • 1-acyl
  • 3hlyso-paf
  • alkylacylglycerophosphocholine
  • arachidonylated
  • ethanolamine-containing
  • ionophore-stimulated
  • 3harachidonate
  • arachidonoyl-coa
  • arachidonate-containing
  • alkylacyl-gpc
  • pharmacology
  • medicine
The enzyme appears in viruses and cellular organisms
coa-independent transacylase, coa-it, coenzyme a-independent transacylase, coait, more
1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine
show the reaction diagram
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