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Information on EC 2.3.1.111 - mycocerosate synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.111 mycocerosate synthase
IUBMB Comments
The enzyme, characterized from mycobacteria, is loaded with a long-chain acyl moiety by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, and elongates it by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the product remains bound and requires additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo.
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Word Map
The expected taxonomic range for this enzyme is: Mycobacterium
Reaction Schemes
a long-chain acyl-[mycocerosic acid synthase]
+
3
+
6
+
6
=
a trimethylated-mycocerosoyl-[mycocerosate synthase]
+
3
+
3
+
6
+
3
a long-chain acyl-[mycocerosic acid synthase]
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4
+
8
+
8
=
a tetramethylated-mycocerosoyl-[mycocerosate synthase]
+
4
+
4
+
8
+
4
Synonyms
mycocerosic acid synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a long-chain acyl-[mycocerosic acid synthase] + 3 methylmalonyl-CoA + 6 NADPH + 6 H+ = a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CoA + 3 CO2 + 6 NADP+ + 3 H2O
show the reaction diagram
(1)
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a long-chain acyl-[mycocerosic acid synthase] + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ = a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
show the reaction diagram
(2)
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-
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