Reference on EC 2.1.4.1 - glycine amidinotransferase
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Walker, J.B.
Biosynthesis of arginine from canavanine and ornithine in kidney
J. Biol. Chem.
218
549-556
1956
no activity in Leuconostoc mesenteroides, Sus scrofa
Walker, J.B.
Studies on the mechanism of action of kidney transamidinase
J. Biol. Chem.
224
57-66
1957
Rattus norvegicus, Sus scrofa
Conconi, F.; Grazi, E.
Transamidinase in hog kidney. I. Purification and properties
J. Biol. Chem.
240
2461-2463
1965
Sus scrofa
Grazi, E.; Conconi, F.; Vigi, V.
Transamidinase in hog kidney. II. Isolation of a stable enzyme-amidine complex
J. Biol. Chem.
240
2465-2467
1965
Sus scrofa
Walker, J.B.
Amidinotranferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
9
497-509
1973
Bos taurus, Canavalia ensiformis, Gallus gallus, Homo sapiens, Lacerta sp., Rana sp., Rattus norvegicus, Sus scrofa
-
Dubach, U.C.
Transamidinase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
740-743
1974
Homo sapiens, Rattus norvegicus, Sus scrofa
-
McGuire, D.M.; Tormanen, C.D.; Segal, I.S.; Van Pilsum, J.F.
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats
J. Biol. Chem.
255
1152-1159
1980
Rattus norvegicus, Sus scrofa
Sipilae, I.
Inhibition of arginine-glycine amidinotransferase by ornithine. A possible mechanism for the muscular and chorioretinal atrophies in gyrate atrophy of the choroid and retina with hyperornithinemia
Biochim. Biophys. Acta
613
79-84
1980
Gallus gallus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Sus scrofa
Gross, M.D.; Eggen, M.A.; Simon, A.M.; Van Pilsum, J.F.
The purification and charcterization of human kidney L-arginine:glycine amidinotransferase
Arch. Biochem. Biophys.
251
747-755
1986
Homo sapiens, Rattus norvegicus, Sus scrofa
Gross, M.D.; Simon, A.M.; Jenny, R.J.; Gray, E.D.; McGuire, D.M.; Van Pilsum, J.F.
Multiple forms of rat kidney L-arginine:glycine amidinotransferase
J. Nutr.
118
1403-1409
1988
Rattus norvegicus
Raman Rao, S.V.R.; Indira, K.
Effects of guanidine hydrochloride on catalytic efficiency of glycine amidinotransferase of rat
Biochem. Mol. Biol. Int.
29
63-67
1993
Rattus norvegicus, Rattus norvegicus Wistar
Guthmiller, P.; Van Pilsum, J.F.; Boen, J.R.; McGuire, D.M.
Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
J. Biol. Chem.
269
17556-17560
1994
Homo sapiens, Rattus norvegicus, Sus scrofa
Watanabe, Y.; Van Pilsum, J.F.; Yokoi, I.; Mori, A.
Synthesis of neuroactive guanidino compounds by rat kidney L-arginine:glycine amidinotransferase
Life Sci.
55
351-358
1994
Felis domestica, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Humm, A.; Fritsche, E.; Mann, K.; Goehl, M.; Huber, R.
Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue
Biochem. J.
322
771-776
1997
Homo sapiens, Homo sapiens (P50440), Sus scrofa, Rattus norvegicus (P50442)
-
Humm, A.; Fritsche, E.; Steinbacher, S.
Structure and reaction mechanism of L-arginine:glycine amidinotransferase
Biol. Chem.
378
193-197
1997
Homo sapiens, Rattus norvegicus, Sus scrofa
Humm, A.; Fritsche, E.; Steinbacher, S.; Huber, R.
Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
EMBO J.
16
3373-3385
1997
Homo sapiens, Homo sapiens (P50440), Rattus norvegicus, Rattus norvegicus (P50442), Sus scrofa
Bedekar, A.; Zink, R.M.; Sherman, D.H.; Line, T.V.; Van Pilsum, J.F.
The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: implications for evolution
Comp. Biochem. Physiol. B
119B
677-690
1998
Homo sapiens, Lampetra planeri, no activity in Streptomyces sp., Rattus norvegicus, Sus scrofa
-
Fritsche, E.; Humm, A.; Huber, R.
The ligand-induced structural changes of human L-arginine:glycine amidinotransferase. A mutational and crystallographic study
J. Biol. Chem.
274
3026-3032
1999
Homo sapiens
Zhu, Y.; Evans, M.I.
Estrogen modulates the expression of L-arginine:glycine amidinotransferase in chick liver
Mol. Cell. Biochem.
221
139-145
2001
Gallus gallus, Gallus gallus (Q9I9K9), Homo sapiens, Rana sp., Rattus norvegicus, Sus scrofa
Carducci, C.; Birarelli, M.; Leuzzi, V.; Carducci, C.; Battini, R.; Cioni, G.; Antonozzi, I.
Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies
Clin. Chem.
48
1772-1778
2002
Homo sapiens
Lee, G.T.; Kim, W.J.; Cho, Y.D.
Polyamine synthesis in plants. Purification and properties of amidinotransferase from soybean (Glycine max) axes
Phytochemistry
61
781-789
2002
Glycine max
Verhoeven, N.M.; Schor, D.S.M.; Roos, B.; Battini, R.; Stockler-Ipsiroglu, S.; Salomons, G.S.; Jakobs, C.
Diagnostic enzyme assay that uses stable-isotope-labeled substrates to detect L-arginine: glycine amidinotransferase deficiency
Clin. Chem.
49
803-805
2003
Homo sapiens
Verhoeven, N.M.; Salomons, G.S.; Jakobs, C.
Laboratory diagnosis of defects of creatine biosynthesis and transport
Clin. Chim. Acta
361
1-9
2005
Homo sapiens
Wang, L.; Chen, D.; Zhang, Y.; Lin, Y.; Li, J.; Zhang, H.
Characterization of AGAT, GAMT and CT1 in amphioxus: implications for the evolutionary conservation of creatine metabolism related molecules at the invertebrate-to-vertebrate transition
Dev. Genes Evol.
218
681-689
2008
Branchiostoma belcheri (Q0GU46)
Braissant, O.; Cagnon, L.; Monnet-Tschudi, F.; Speer, O.; Wallimann, T.; Honegger, P.; Henry, H.
Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency
Eur. J. Neurosci.
27
1673-1685
2008
Rattus norvegicus (P50442)
Braissant, O.; Henry, H.
AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review
J. Inherit. Metab. Dis.
31
230-239
2008
Mammalia
Braissant, O.; Bachmann, C.; Henry, H.
Expression and function of AGAT, GAMT and CT1 in the mammalian brain
Subcell. Biochem.
46
67-81
2007
Rattus norvegicus
Bera, S.; Wallimann, T.; Ray, S.; Ray, M.
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells
FEBS J.
275
5899-5909
2008
Mus musculus
Bourdelas, A.; Li, H.Y.; Carron, C.; Shi, D.L.
Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development
Int. J. Dev. Biol.
53
1075-1079
2009
Xenopus laevis (Q9IAJ6)
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
J. Nutr.
139
1292-1297
2009
Sus scrofa
Muenchhoff, J.; Siddiqui, K.S.; Poljak, A.; Raftery, M.J.; Barrow, K.D.; Neilan, B.A.
A novel prokaryotic L-arginine:glycine amidinotransferase is involved in cylindrospermopsin biosynthesis
FEBS J.
277
3844-3860
2010
Cylindrospermopsis raciborskii (B0LI36), Cylindrospermopsis raciborskii AWT205 (B0LI36), Cylindrospermopsis raciborskii AWT205
Muenchhoff, J.; Siddiqui, K.S.; Neilan, B.A.
Identification of two residues essential for the stringent substrate specificity and active site stability of the prokaryotic L-arginine:glycine amidinotransferase CyrA
FEBS J.
279
805-815
2012
Cylindrospermopsis raciborskii (B0LI36), Cylindrospermopsis raciborskii AWT205 (B0LI36)
Choe, C.U.; Atzler, D.; Wild, P.S.; Carter, A.M.; Boeger, R.H.; Ojeda, F.; Simova, O.; Stockebrand, M.; Lackner, K.; Nabuurs, C.; Marescau, B.; Streichert, T.; Mueller, C.; Lueneburg, N.; De Deyn, P.P.; Benndorf, R.A.; Baldus, S.; Gerloff, C.; Blankenberg, S.; Heerschap, A.; Grant, P.J.; Magnus, T.; Zeller, T.; Isbrandt, D.; Schwedhelm, E.
Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies
Circulation
128
1451-1461
2013
Homo sapiens (P50440), Homo sapiens, Mus musculus (Q9D964), Mus musculus, Mus musculus C57BL6 (Q9D964)
Jang, H.J.; Lee, M.O.; Kim, S.; Kim, T.H.; Kim, S.K.; Song, G.; Womack, J.E.; Han, J.Y.
Biallelic expression of the L-arginine:glycine amidinotransferase gene with different methylation status between male and female primordial germ cells in chickens
Poult. Sci.
92
760-769
2013
Gallus gallus (Q9I9K9), Gallus gallus, Gallus gallus White leghorn (Q9I9K9), Gallus gallus Korean Oge (Q9I9K9)
Faller, K.M.E.; Atzler, D.; McAndrew, D.J.; Zervou, S.; Whittington, H.J.; Simon, J.N.; Aksentijevic, D.; Ten Hove, M.; Choe, C.U.; Isbrandt, D.; Casadei, B.; Schneider, J.E.; Neubauer, S.; Lygate, C.A.
Impaired cardiac contractile function in arginine glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine
Cardiovasc. Res.
114
417-430
2018
Mus musculus
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