Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

No. of entries

Information on EC 2.1.2.1 - glycine hydroxymethyltransferase

for references in articles please use BRENDA:EC2.1.2.1

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.

The enzyme appears in viruses and cellular organisms

Synonyms
serine hydroxymethyltransferase, shmt2, shmt1, serine hydroxymethyl transferase, serine transhydroxymethylase, serine hydroxymethyltransferase 2, mitochondrial serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, bsshmt, pvshmt, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
dTMP de novo biosynthesis (mitochondrial), folate polyglutamylation, folate transformations I, folate transformations II (plants), folate transformations III (E. coli), formaldehyde assimilation I (serine pathway), glycine betaine degradation I, glycine betaine degradation II (mammalian), glycine betaine degradation III, glycine biosynthesis I, photorespiration I, photorespiration II, photorespiration III, purine nucleobases degradation II (anaerobic)