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(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-Ser
-
Substrates: the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
5,6,7,8-tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
D-alanine + 4-(benzyloxy)butanal + H2O
(3R)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline + (3S)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline
Substrates: -
Products: -
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D-alanine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid
Substrates: -
Products: -
?
D-alanine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid
Substrates: -
Products: -
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D-alanine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid
Substrates: -
Products: -
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D-alanine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid
Substrates: -
Products: -
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D-alanine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid
Substrates: -
Products: -
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D-alanine + benzyl (2-oxoethyl)carbamate + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline
Substrates: -
Products: -
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D-alanine + benzyl (3-oxopropyl)carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylhexanoic acid
Substrates: -
Products: -
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D-alanine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine
Substrates: -
Products: -
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D-alanine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(3S,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline + (3R,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline
Substrates: -
Products: -
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D-alanine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid
Substrates: -
Products: -
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D-alanine + phenoxyacetaldehyde + H2O
(3R)-3-hydroxy-4-phenoxy-L-isovaline + (3S)-3-hydroxy-4-phenoxy-L-isovaline
Substrates: -
Products: -
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D-alanine + phenylacetaldehyde + H2O
(3S)-3-hydroxy-4-phenyl-L-isovaline + (3R)-3-hydroxy-4-phenyl-L-isovaline
Substrates: -
Products: -
?
D-serine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline + (3S)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline
Substrates: -
Products: -
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D-serine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid
Substrates: -
Products: -
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D-serine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline
Substrates: -
Products: -
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D-serine + 4-(benzyloxy)butanal + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3S)-2',3-dihydroxy-4-(3-phenylpropoxy)-L-isovaline
Substrates: -
Products: -
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D-serine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid
Substrates: -
Products: -
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D-serine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid
Substrates: -
Products: -
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D-serine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
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D-serine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid
Substrates: -
Products: -
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D-serine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-phenylpropanoic acid
Substrates: -
Products: -
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D-serine + benzyl (2-oxoethyl)carbamate + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline
Substrates: -
Products: -
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D-serine + benzyl (3-oxopropyl)carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-(hydroxymethyl)-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-(hydroxymethyl)-L-lysine
Substrates: -
Products: -
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D-serine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(3S,4R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline + (3R,4R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline
Substrates: -
Products: -
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D-serine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(3S,4S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline + (3R,4S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline
Substrates: -
Products: -
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D-serine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(pentafluorophenyl)propanoic acid
Substrates: -
Products: -
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D-serine + phenoxyacetaldehyde + H2O
(3R)-2',3-dihydroxy-4-phenoxy-L-isovaline + (3S)-2',3-dihydroxy-4-phenoxy-L-isovaline
Substrates: -
Products: -
?
D-serine + phenylacetaldehyde + H2O
(3S)-2',3-dihydroxy-4-phenyl-L-isovaline + (3R)-2',3-dihydroxy-4-phenyl-L-isovaline
Substrates: -
Products: -
?
D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
DL-3-phenylserine + ?
benzaldehyde + ?
Substrates: -
Products: -
?
DL-phenylserine + ?
benzaldehyde + ?
-
Substrates: -
Products: -
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glycine + (benzyloxy)acetaldehyde + H2O
(2S,3R)-2-amino-4-(benzyloxy)-3-hydroxybutanoic acid + (2S,3S)-2-amino-4-(benzyloxy)-3-hydroxybutanoic acid
Substrates: -
Products: -
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glycine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxypropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxypropanoic acid
Substrates: -
Products: -
?
glycine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-5-phenyl-L-norvaline + (3R)-3-hydroxy-5-phenyl-L-norvaline
Substrates: -
Products: -
?
glycine + 4-(benzyloxy)butanal + H2O
(2S,3R)-2-amino-3-hydroxy-4-(3-phenylpropoxy)butanoic acid + (2S,3S)-2-amino-3-hydroxy-4-(3-phenylpropoxy)butanoic acid
Substrates: -
Products: -
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glycine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxypropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxypropanoic acid
Substrates: -
Products: -
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glycine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxypropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxypropanoic acid
Substrates: -
Products: -
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glycine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
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glycine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid
Substrates: -
Products: -
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glycine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-phenylpropanoic acid
Substrates: -
Products: -
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glycine + benzyl (2-oxoethyl)carbamate + H2O
(2S,3S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid + (2S,3R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid
Substrates: -
Products: -
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glycine + benzyl (3-oxopropyl)carbamate + H2O
(2S,3S)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxyhexanoic acid + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxyhexanoic acid
Substrates: -
Products: -
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glycine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(2S,3S,4R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylpentanoic acid + (2S,3S,4R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid
Substrates: -
Products: -
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glycine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(2S,3R,4S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid + (2S,3S,4S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid
Substrates: -
Products: -
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glycine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(pentafluorophenyl)propanoic acid
Substrates: -
Products: -
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glycine + phenoxyacetaldehyde + H2O
(2S,3R)-2-amino-3-hydroxy-4-phenoxybutanoic acid + (2S,3S)-2-amino-3-hydroxy-4-phenoxybutanoic acid
Substrates: -
Products: -
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glycine + phenylacetaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-4-phenylbutanoic acid + (2S,3R)-2-amino-3-hydroxy-4-phenylbutanoic acid
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
L-serine + modified folate
glycine + modified methylenefolate
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine
tetrahydrofolate + L-Ser
? + glycine + H2O
-
Substrates: -
Products: -
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tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydromethanopterin + L-Ser
glycine + ?
-
Substrates: -
Products: -
?
tetrahydropteroylglutamate + L-Ser
glycine + ?
-
Substrates: -
Products: -
?
additional information
?
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(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: poor activity
Products: -
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(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
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(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
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(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
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(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: the enzyme also catalyzes the formation of methylene-tetrahydromethanopterin from tetrahydromethanopterin and L-serine, albeit with a catalytic efficiency which is less than 1% of that with (6S)-tetrahydrofolate as substrate. The catalytic efficiency with methylene-tetrahydrosarcinapterin as substrate is even lower
Products: -
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(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: the enzyme also catalyzes the formation of methylene-tetrahydromethanopterin from tetrahydromethanopterin and L-serine, albeit with a catalytic efficiency which is less than 1% of that with (6S)-tetrahydrofolate as substrate. The catalytic efficiency with methylene-tetrahydrosarcinapterin as substrate is even lower
Products: -
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(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
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(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
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5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
-
Substrates: -
Products: -
?
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: i.e. tetrahydropteroylglutamate, tetrahydropteroylglutamates with more than one glutamate residue are poor substrates and competitive inhibitors, overview
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: at high concentrations of enzyme
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
Substrates: -
Products: -
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D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
Substrates: -
Products: -
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D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
Substrates: -
Products: -
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D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
Substrates: -
Products: -
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D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
Substrates: -
Products: -
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D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
Substrates: -
Products: -
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D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: the catalytic efficiency for D-serine is 580fold lower than that of L-serine
Products: -
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D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: the catalytic efficiency for D-serine is 580fold lower than that of L-serine
Products: -
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D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: the binding affinity for D-serine is 150fold lower than that of L-serine
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
Substrates: placental conversion of serine to glycine is a major source of fetal glycine
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + modified folate
glycine + modified methylenefolate
Substrates: not: tetrahydrofolate, synthetic modified folate derivate
Products: -
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L-serine + modified folate
glycine + modified methylenefolate
Substrates: not: tetrahydrofolate, synthetic modified folate derivate
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: catalyzes interconversion of serine and glycine
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: adding 2fold more glycine in the medium increases significantly the expression of SHMT-S and to an even higher level, the expression of SHMT-L, adding 2fold more serine has the reverse effect on the expression of SHMT-L, while the expression of SHMT-S does not change significantly
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: regulatory protein
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme is a component of thymidylate cycle
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: catalyzes interconversion of serine and glycine
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme is a component of thymidylate cycle
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: only (6S)-tetrahydrofolate can serve as a substrate for His6-tagged SHMT, the presence of (6R)-tetrahydrofolate has no interference to the reaction
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: only (6S)-tetrahydrofolate can serve as a substrate for His6-tagged SHMT, the presence of (6R)-tetrahydrofolate has no interference to the reaction
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: L-serine is the physiological substrate
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: catalyzes interconversion of serine and glycine
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: SHMT antisense plants display lower photosynthetic capacity and accumulate glycine in light, glycine is converted to serine in the second half of the light period, serine shows an inverse diurnal rhythm and reaches highest values in darkness, glycine/serine conversion is independent of light in the transformant, but not in the wild-type
Products: -
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L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: regulatory protein
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
-
Substrates: -
Products: -
r
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
-
Substrates: -
Products: -
r
NADH + coenzyme Q10
?
Substrates: -
Products: -
?
NADH + coenzyme Q10
?
Substrates: -
Products: -
?
tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine
Substrates: -
Products: -
r
tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
additional information
?
-
-
Substrates: the enzyme is also active with DL-threo-3-phenylserine
Products: -
?
additional information
?
-
Substrates: purified recombinant ApSHMT protein exhibits catalytic reactions for DL-threo-3-phenylserine as well as for L-serine
Products: -
?
additional information
?
-
-
Substrates: purified recombinant ApSHMT protein exhibits catalytic reactions for DL-threo-3-phenylserine as well as for L-serine
Products: -
?
additional information
?
-
-
Substrates: SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death
Products: -
?
additional information
?
-
-
Substrates: SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death
Products: -
?
additional information
?
-
-
Substrates: SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate
Products: -
?
additional information
?
-
-
Substrates: broad substrate and reaction specificity
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
Substrates: disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine
Products: -
?
additional information
?
-
-
Substrates: disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine
Products: -
?
additional information
?
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
Substrates: enzyme catalyses the racemization of D- and L-alanine
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyses the racemization of D- and L-alanine
Products: -
?
additional information
?
-
-
Substrates: 3-phenylserine is used as a substrate
Products: -
?
additional information
?
-
-
Substrates: SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate
Products: -
?
additional information
?
-
-
Substrates: broad substrate and reaction specificity, overview
Products: -
?
additional information
?
-
-
Substrates: SHMT activity with beta-phenylserine as substrate is about 1.48fold and 1.25fold higher than that with beta-(methylsulfonylphenyl) serine and beta-(nitrophenyl) serine as substrate, respectively. Besides SHMT activity, the enzyme also shows L-allo-threonine aldolase activity, EC 4.1.2.48
Products: -
?
additional information
?
-
-
Substrates: SHMT activity with beta-phenylserine as substrate is about 1.48fold and 1.25fold higher than that with beta-(methylsulfonylphenyl) serine and beta-(nitrophenyl) serine as substrate, respectively. Besides SHMT activity, the enzyme also shows L-allo-threonine aldolase activity, EC 4.1.2.48
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: no: D-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: no: D-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: no: D-threonine
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyses the racemization of D- and L-alanine
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyses the racemization of D- and L-alanine
Products: -
?
additional information
?
-
Substrates: SHMT also catalyses several tetrahydrofolate-independent side reactions such as cleavage of beta-hydroxy amino acids, transamination, racemization and decarboxylation
Products: -
?
additional information
?
-
-
Substrates: SHMT also catalyses several tetrahydrofolate-independent side reactions such as cleavage of beta-hydroxy amino acids, transamination, racemization and decarboxylation
Products: -
?
additional information
?
-
-
Substrates: the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
Products: -
?
additional information
?
-
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine
Products: -
?
additional information
?
-
-
Substrates: the enzyme plays an indispensable role in nucleic acid biosynthesis
Products: -
?
additional information
?
-
-
Substrates: human serine hydroxymethyltransferase 2 binds specifically to heterogeneous nuclear ribonucleoprotein D
Products: -
?
additional information
?
-
-
Substrates: the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
Products: -
?
additional information
?
-
-
Substrates: the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: no: D-threonine
Products: -
?
additional information
?
-
-
Substrates: insoluble enzyme/antibody-complex shows 90% of original activity
Products: -
?
additional information
?
-
Substrates: the enzyme also catalyzes the tetrahydrofolate-independent retroaldol cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde
Products: -
?
additional information
?
-
Substrates: the enzyme also catalyzes the tetrahydrofolate-independent retroaldol cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde
Products: -
?
additional information
?
-
Substrates: SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
-
Substrates: SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
-
Substrates: SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
Substrates: SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: mutant enzyme H230Y catalyses oxidation of NADH, not wild type enzyme, H230A, H230F, H230N
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyses the racemization of D- and L-alanine
Products: -
?
additional information
?
-
-
Substrates: the enzyme also exhibits THF-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
Products: -
?
additional information
?
-
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: Plasmodium SHMT can use D-serine and L-serine as a substrate
Products: -
?
additional information
?
-
-
Substrates: SHMT also catalyzes the tetrahydrofolate-independent retro-aldol cleavage of 3-hydroxy amino acids
Products: -
?
additional information
?
-
-
Substrates: Plasmodium SHMT can use D-serine and L-serine as a substrate
Products: -
?
additional information
?
-
-
Substrates: serine hydroxymethyltransferase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes a hydroxymethyl group transfer from L-serine to tetrahydrofolate to yield glycine and 5,10-methylenetetrahydrofolate
Products: -
?
additional information
?
-
Substrates: the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction
Products: -
?
additional information
?
-
-
Substrates: the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction
Products: -
?
additional information
?
-
Substrates: L- and D-serine substrate binding structure analysis, overview
Products: -
?
additional information
?
-
-
Substrates: L- and D-serine substrate binding structure analysis, overview
Products: -
?
additional information
?
-
Substrates: SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity
Products: -
?
additional information
?
-
Substrates: SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: no: D-threonine
Products: -
?
additional information
?
-
-
Substrates: low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: no: D-serine
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
-
Substrates: no: D-allothreonine
Products: -
?
additional information
?
-
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: no: L-threonine
Products: -
?
additional information
?
-
-
Substrates: enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
Products: -
?
additional information
?
-
Substrates: the enzyme shows high serine hydroxymethyltransferase activity and L-serine production
Products: -
?
additional information
?
-
-
Substrates: the enzyme shows high serine hydroxymethyltransferase activity and L-serine production
Products: -
?
additional information
?
-
-
Substrates: review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
Products: -
?
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(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-Ser
-
Substrates: the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
Substrates: placental conversion of serine to glycine is a major source of fetal glycine
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
additional information
?
-
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Substrates: -
Products: -
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: catalyzes interconversion of serine and glycine
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: regulatory protein
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: main glycine source for purine biosynthetic pathway in ureide biogenesis
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme is a component of thymidylate cycle
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: catalyzes interconversion of serine and glycine
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme is a component of thymidylate cycle
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: catalyzes interconversion of serine and glycine
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: may play important role in central nervous system
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: -
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: regulatory protein
Products: -
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Substrates: key enzyme of serine pathway for assimilation of C1-compounds
Products: -
?
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
-
Substrates: -
Products: -
r
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
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r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
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Substrates: -
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r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
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Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Substrates: -
Products: -
r
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Substrates: SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death
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Substrates: SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death
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Substrates: SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate
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Substrates: disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine
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Substrates: disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine
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Substrates: SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate
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Substrates: low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine
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Substrates: the enzyme plays an indispensable role in nucleic acid biosynthesis
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Substrates: Plasmodium SHMT can use D-serine and L-serine as a substrate
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Substrates: Plasmodium SHMT can use D-serine and L-serine as a substrate
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Substrates: serine hydroxymethyltransferase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes a hydroxymethyl group transfer from L-serine to tetrahydrofolate to yield glycine and 5,10-methylenetetrahydrofolate
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Substrates: the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction
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Substrates: the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction
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Substrates: SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity
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Substrates: SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity
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Substrates: low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine
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Substrates: the enzyme shows high serine hydroxymethyltransferase activity and L-serine production
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Substrates: the enzyme shows high serine hydroxymethyltransferase activity and L-serine production
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