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Information on EC 2.1.1.350 - menaquinone C8-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.350 menaquinone C8-methyltransferase
IUBMB Comments
The enzyme, found in a wide range of bacteria and archaea, is a radical SAM (AdoMet) enzyme that utilizes two molecules of S-adenosyl-L-methionine, one as the methyl group donor, and one for the creation of a 5'-deoxyadenosine radical that drives the reaction forward.
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The expected taxonomic range for this enzyme is: Adlercreutzia equolifaciens
Synonyms
Aequ0025, menK, mqnK, radical SAM menaquinone methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + a 2-demethylmenaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + oxidized flavodoxin
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(2)
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2 S-adenosyl-L-methionine + a menaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + an 8-methylmenaquinone + oxidized flavodoxin
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
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