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Information on EC 2.1.1.264 - 23S rRNA (guanine2069-N7)-methyltransferase

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IUBMB Comments
The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In gamma-proteobacteria the enzyme also catalyses EC 2.1.1.173, 23S rRNA (guanine2445-N2)-methyltransferase, while in beta-proteobacteria the activities are carried out by separate proteins . The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well .
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
sav1081, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
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