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Information on EC 2.1.1.260 - rRNA small subunit pseudouridine methyltransferase Nep1

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IUBMB Comments
This enzyme, which occurs in both prokaryotes and eukaryotes, recognizes specific pseudouridine residues (Psi) in small subunits of ribosomal RNA based on the local RNA structure. It recognizes Psi914 in 16S rRNA from the archaeon Methanocaldococcus jannaschii, Psi1191 in yeast 18S rRNA, and Psi1248 in human 18S rRNA.
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Word Map
The expected taxonomic range for this enzyme is: Archaea, Eukaryota
Reaction Schemes
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pseudouridine1191 in yeast 18S rRNA
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N1-methylpseudouridine1191 in yeast 18S rRNA
Synonyms
nep1p, essential for mitotic growth 1, n1-specific pseudouridine methyltransferase, nucleolar essential protein 1, nep1 methyltransferase, pseudouridine n1-methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + pseudouridine1191 in yeast 18S rRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine1191 in yeast 18S rRNA
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