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Information on EC 2.1.1.254 - erythromycin 3''-O-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.254 erythromycin 3''-O-methyltransferase
IUBMB Comments
The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase.
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The expected taxonomic range for this enzyme is: Saccharopolyspora erythraea
Synonyms
EryG, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A
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S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B
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