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Information on EC 2.1.1.250 - trimethylamine-corrinoid protein Co-methyltransferase

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IUBMB Comments
The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine . Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
+
a [Co(I) trimethylamine-specific corrinoid protein]
=
a [methyl-Co(III) trimethylamine-specific corrinoid protein]
+
Synonyms
DSY3156 protein, glycine betaine:cob(I)alamin methyltransferase, MMA methyltransferase 1, MMA methyltransferase 2, MtgB, MttB, mttB1C1, mttB2C2, nonpyrrolysine MttB homolog, TMA methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] = a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
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