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Information on EC 2.1.1.249 - dimethylamine-corrinoid protein Co-methyltransferase

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IUBMB Comments
The enzyme, which catalyses the transfer of a methyl group from dimethylamine to a dimethylamine-specific corrinoid protein (MtbC), is involved in methanogenesis from dimethylamine. The enzyme contains the unusual amino acid pyrrolysine . Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
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The expected taxonomic range for this enzyme is: Methanosarcina
Reaction Schemes
+
a [Co(I) dimethylamine-specific corrinoid protein]
=
a [methyl-Co(III) dimethylamine-specific corrinoid protein]
+
Synonyms
mtbb1, dma-mt, dma methyltransferase, mtbb2, mtbb3, dimethylamine/5-hydroxybenzimidazolylcobamide methyltransferase, dimethylamine:corrinoid methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] = a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
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