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Information on EC 2.1.1.246 - [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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IUBMB Comments
The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro .
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The expected taxonomic range for this enzyme is: Methanosarcina
Reaction Schemes
a [methyl-Co(III) methanol-specific corrinoid protein]
+
=
+
a [Co(I) methanol-specific corrinoid protein]
Synonyms
methyltransferase 2, mt2-a, mt2-m, methanol:coenzyme m methyltransferase, methylcobalamin:coenzyme m methyltransferase, methylcobamide:com methyltransferase, methanol-specific methyltransferase 2, methylcobamide:coenzyme m methyltransferase, co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [methyl-Co(III) methanol-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]
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