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Information on EC 2.1.1.226 - 23S rRNA (cytidine1920-2'-O)-methyltransferase

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IUBMB Comments
The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
2'-O-methyltransferase, TlyA, TlyAI, TlyAII, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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