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Reference on EC 2.1.1.224 - 23S rRNA (adenine2503-C8)-methyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Long, K.S.; Poehlsgaard, J.; Kehrenberg, C.; Schwarz, S.; Vester, B.
The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics
Antimicrob. Agents Chemother.
50
2500-2505
2006
Escherichia coli
Manually annotated by BRENDA team
Yan, F.; LaMarre, J.M.; Rhrich, R.; Wiesner, J.; Jomaa, H.; Mankin, A.S.; Fujimori, D.G.
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA
J. Am. Chem. Soc.
132
3953-3964
2010
Escherichia coli
Manually annotated by BRENDA team
Kehrenberg, C.; Schwarz, S.; Jacobsen, L.; Hansen, L.H.; Vester, B.
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503
Mol. Microbiol.
57
1064-1073
2005
Escherichia coli
Manually annotated by BRENDA team
Kaminska, K.H.; Purta, E.; Hansen, L.H.; Bujnicki, J.M.; Vester, B.; Long, K.S.
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria
Nucleic Acids Res.
38
1652-1663
2009
Escherichia coli
Manually annotated by BRENDA team
Giessing, A.M.; Jensen, S.S.; Rasmussen, A.; Hansen, L.H.; Gondela, A.; Long, K.; Vester, B.; Kirpekar, F.
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria
RNA
15
327-336
2009
Escherichia coli K-12 (P36979)
Manually annotated by BRENDA team
Yan, F.; Fujimori, D.G.
RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift
Proc. Natl. Acad. Sci. USA
108
3930-3934
2011
Escherichia coli
Manually annotated by BRENDA team
Boal, A.K.; Grove, T.L.; McLaughlin, M.I.; Yennawar, N.H.; Booker, S.J.; Rosenzweig, A.C.
Structural basis for methyl transfer by a radical SAM enzyme
Science
332
1089-1092
2011
Escherichia coli
Manually annotated by BRENDA team
Grove, T.L.; Benner, J.S.; Radle, M.I.; Ahlum, J.H.; Landgraf, B.J.; Krebs, C.; Booker, S.J.
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases
Science
332
604-607
2011
Escherichia coli
Manually annotated by BRENDA team
LaMarre, J.M.; Locke, J.B.; Shaw, K.J.; Mankin, A.S.
Low fitness cost of the multidrug resistance gene cfr
Antimicrob. Agents Chemother.
55
3714-3719
2011
Staphylococcus aureus, Staphylococcus aureus RN4220
Manually annotated by BRENDA team
Locke, J.B.; Rahawi, S.; Lamarre, J.; Mankin, A.S.; Shaw, K.J.
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05
Antimicrob. Agents Chemother.
56
332-340
2012
Staphylococcus aureus (E1VCY5), Staphylococcus aureus, Staphylococcus aureus CM05 (E1VCY5), Staphylococcus aureus CM05
Manually annotated by BRENDA team
Hansen, L.H.; Planellas, M.H.; Long, K.S.; Vester, B.
The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene
Antimicrob. Agents Chemother.
56
3563-3567
2012
Bacillus amyloliquefaciens, Brevibacillus brevis (C0ZJA6), Alkalihalobacillus clausii (Q5WJ42), Bacillus amyloliquefaciens FZB42, Brevibacillus brevis NBRC 100599 (C0ZJA6)
Manually annotated by BRENDA team
Booth, M.P.; Challand, M.R.; Emery, D.C.; Roach, P.L.; Spencer, J.
High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics
Protein Expr. Purif.
74
204-210
2010
Azotobacter vinelandii
Manually annotated by BRENDA team
Atkinson, G.C.; Hansen, L.H.; Tenson, T.; Rasmussen, A.; Kirpekar, F.; Vester, B.
Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase
Antimicrob. Agents Chemother.
57
4019-4026
2013
Mammaliicoccus sciuri (Q9FBG4)
Manually annotated by BRENDA team
Challand, M.R.; Salvadori, E.; Driesener, R.C.; Kay, C.W.; Roach, P.L.; Spencer, J.
Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase
PLoS ONE
8
e67979
2013
Staphylococcus aureus, Mammaliicoccus sciuri (Q9FBG4)
Manually annotated by BRENDA team
Hansen, L.H.; Vester, B.
A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene
Antimicrob. Agents Chemother.
59
5841-5843
2015
Clostridioides difficile (V5ZEZ1), Clostridioides difficile
Manually annotated by BRENDA team
Wang, C.; Yang, X.; Wang, E.; Li, B.
Quantum chemistry studies of adenosine 2503 methylation by S-adenosylmethionine-dependent enzymes
Int. J. Quantum Chem.
113
1409-1415
2013
Staphylococcus aureus (A5HBL2)
-
Manually annotated by BRENDA team
Pakula, K.K.; Hansen, L.H.; Vester, B.
Combined effect of the Cfr methyltransferase and ribosomal protein L3 mutations on resistance to ribosome-targeting antibiotics
Antimicrob. Agents Chemother.
61
e00862-17
2017
Staphylococcus sp.
Manually annotated by BRENDA team
Stojkovic, V.; Ulate, M.F.; Hidalgo-Villeda, F.; Aguilar, E.; Monge-Cascante, C.; Pizarro-Guajardo, M.; Tsai, K.; Tzoc, E.; Camorlinga, M.; Paredes-Sabja, D.; Quesada-Gomez, C.; Fujimori, D.G.; Rodriguez, C.
cfr(B), cfr(C), and a new cfr-like gene, cfr(E), in Clostridium difficile strains recovered across Latin America
Antimicrob. Agents Chemother.
64
e01074-19
2019
Clostridioides difficile, Clostridioides difficile DF11
Manually annotated by BRENDA team
Candela, T.; Marvaud, J.; Nguyen, T.; Lambert, T.
A cfr-like gene cfr(C) conferring linezolid resistance is common in Clostridium difficile
Int. J. Antimicrob. Agents
50
496-500
2017
Enterocloster bolteae, Clostridioides difficile (V5ZEQ2), Clostridioides difficile, Clostridioides difficile T10 (V5ZEQ2), Clostridioides difficile T10, Enterocloster bolteae 90B3
Manually annotated by BRENDA team
Ntokou, E.; Hansen, L.; Kongsted, J.; Vester, B.
Biochemical and computational analysis of the substrate specificities of Cfr and RlmN Methyltransferases
PLoS ONE
10
e0145655
2015
Mammaliicoccus sciuri (Q9FBG4)
Manually annotated by BRENDA team
Fitzsimmons, C.M.; Fujimori, D.G.
Determinants of tRNA recognition by the radical SAM enzyme RlmN
PLoS ONE
11
e0167298
2016
Enterococcus faecalis (A0A2Z6BLR4), Bacillus amyloliquefaciens (A0A4V7TJX0), Paenibacillus lautus (D3EIG6), Clostridioides difficile (V5ZEQ2), Bacillus amyloliquefaciens DSM-7 (A0A4V7TJX0), Paenibacillus lautus Y412MC10 (D3EIG6), Enterococcus faecalis TX0645 (A0A2Z6BLR4), Clostridioides difficile QCD63q42 (V5ZEQ2)
Manually annotated by BRENDA team
Boal, A.K.; Grove, T.L.; McLaughlin, M.I.; Yennawar, N.H.; Booker, S.J.; Rosenzweig, A.C.
Structural basis for methyl transfer by a radical SAM enzyme
Science
332
1089-1092
2011
Staphylococcus aureus (A5HBL2)
Manually annotated by BRENDA team
Schwalm, E.; Grove, T.; Booker, S.; Boal, A.
Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA
Science
352
309-312
2016
Escherichia coli
Manually annotated by BRENDA team