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Information on EC 2.1.1.218 - tRNA (adenine9-N1)-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.218 tRNA (adenine9-N1)-methyltransferase
IUBMB Comments
The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA . The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase).
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The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
Synonyms
TK0422p, Trm10p (ambiguous), tRNA m1A9 MTase, tRNA m1A9-methyltransferase, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + adenine9 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA
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