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Information on EC 2.1.1.215 - tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

for references in articles please use BRENDA:EC2.1.1.215
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IUBMB Comments
The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216, tRNA (guanine26-N2)-dimethyltransferase). However, it catalyses the double methylation of guanines at both positions 26 and 27 of tRNA.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
4
+
guanine26/guanine27 in tRNA
=
4
+
N2-dimethylguanine26/N2-dimethylguanine27 in tRNA
Synonyms
trna (m2(2)g26) methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4 S-adenosyl-L-methionine + guanine26/guanine27 in tRNA = 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26/N2-dimethylguanine27 in tRNA
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