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Information on EC 2.1.1.202 - multisite-specific tRNA:(cytosine-C5)-methyltransferase

for references in articles please use BRENDA:EC2.1.1.202
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EC Tree
IUBMB Comments
The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA. The incidence of modification depends on the cytosine position in tRNA. At positions 34 and 40, 5-methylcytosine is found only in two yeast tRNAs (tRNALeu(CUA) and tRNAPhe(GAA), respectively), whereas most other elongator yeast tRNAs bear either 5-methylcytosine48 or 5-methylcytosine49, but never both in the same tRNA molecule . The formation of 5-methylcytosine34 and 5-methylcytosine40 is a strictly intron-dependent process, whereas the formation of 5-methylcytosine48 and 5-methylcytosine49 is an intron-independent process [2,3].
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Word Map
  • 2.1.1.202
  • methyltransferases
  • anticodon
  • bisulfite
  • wobble
  • protein-rna
  • s-adenosyl-l-methionine-dependent
  • enzyme-rna
  • mtases
  • transcriptome-wide
  • pre-trnas
  • intron-dependent
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
hide(3 overall reactions are displayed. Show all (4)>>)
Synonyms
trm4p, trm4b, ncl1p, rna:m5c methyltransferase, mj0026, trna:m5c-methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + cytosine34 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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S-adenosyl-L-methionine + cytosine40 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine40 in tRNA precursor
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S-adenosyl-L-methionine + cytosine48 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine48 in tRNA
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S-adenosyl-L-methionine + cytosine49 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine49 in tRNA
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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