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Information on EC 2.1.1.188 - 23S rRNA (guanine748-N1)-methyltransferase

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IUBMB Comments
The enzyme specifically methylates guanine748 at N1 in 23S rRNA. The methyltransferase RlmAII confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae .
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
rlma(ii), rlmaii, methyltransferase rlmaii, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + guanine748 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
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