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Disease on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease.
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.
PEMT G523A (V175M) Is Associated with Sporadic Alzheimer's Disease in a Chinese Population.
Asthma
A pilot study to evaluate self initiated computer patient education in children with acute asthma in pediatric emergency department.
Prospective tracking of a pediatric emergency department e-kiosk to deliver asthma education.
[Membrane phosphatidylethanolamine methylase in blood leukocytes and alveolar macrophages of asthmatic patients]
Atherosclerosis
From Masochistic Enzymology to Mechanistic Physiology and Disease.
Hepatic Expression of PEMT, but Not Dietary Choline Supplementation, Reverses the Protection against Atherosclerosis in Pemt-/-/Ldlr-/- Mice.
Impaired Phosphatidylcholine Biosynthesis Reduces Atherosclerosis and Prevents Lipotoxic Cardiac Dysfunction in ApoE-/- Mice.
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
Phospholipid methylation in mammals: from biochemistry to physiological function.
Breast Neoplasms
Choline metabolism and risk of breast cancer in a population-based study.
Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China.
Epigenetic repression of phosphatidylethanolamine, N-methyltransferase (PEMT) in BRCA1-mutated breast cancer.
Carcinoma
Partial EMT in Squamous Cell Carcinoma: A Snapshot.
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
Carcinoma, Hepatocellular
A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.
An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins.
Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis.
Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas.
Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats.
Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.
Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.
Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats.
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells.
Induction of hepatocyte proliferation after partial hepatectomy is accompanied by a markedly reduced expression of phosphatidylethanolamine N-methyltransferase-2.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase.
Over-expression of pemt2 into rat hepatoma cells contributes to the mitochondrial apoptotic pathway.
Plasma homocysteine is regulated by phospholipid methylation.
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
[Comparison of the expression and activity of phosphatidylethanolamine N-methyltransferase 2 between primary cultured hepatocytes and hepatoma cells in rats]
Carcinoma, Squamous Cell
Partial EMT in Squamous Cell Carcinoma: A Snapshot.
Cholestasis, Intrahepatic
The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis.
Choline Deficiency
Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.
Common genetic polymorphisms affect the human requirement for the nutrient choline.
Effect of choline deficiency on the enzymes that synthesize phosphatidylcholine and phosphatidylethanolamine in rat liver.
No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats.
Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report.
Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency.
Colonic Neoplasms
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
Congenital Abnormalities
Choline metabolites: gene by diet interactions.
cystathionine beta-synthase deficiency
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Cystic Fibrosis
Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.
Lymphocyte and granulocyte phosphatidylethanolamine N-methyltransferase: properties and activity in cystic fibrosis.
Diabetes Mellitus
Higher homocysteine and lower betaine increases the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C.
Diabetes Mellitus, Type 1
Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy.
Diabetes Mellitus, Type 2
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
Diabetic Nephropathies
Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy.
Dyspnea
Diagnostic accuracy of physician-staffed emergency medical teams: a retrospective observational cohort study of prehospital versus hospital diagnosis in a 10-year interval.
Endometriosis
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Fatty Liver
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice.
Phospholipid methylation in mammals: from biochemistry to physiological function.
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.
Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.
Fetal Death
Importance of polymorphic variants of phosphatidylethanolamine N-methyltransferase (PEMT) gene in the etiology of intrauterine fetal death in the Polish population.
Gallstones
Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice.
glycine n-methyltransferase deficiency
Methyl balance and transmethylation fluxes in humans.
guanidinoacetate n-methyltransferase deficiency
Methyl balance and transmethylation fluxes in humans.
Homocystinuria
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Hyperhomocysteinemia
Plasma homocysteine is regulated by phospholipid methylation.
Hyperthyroidism
The effect of hyper and hypothyroidism, hypophysectomy and adrenalectomy on phosphatidylethanolamine methyltransferase, phosphatidyldimethyl-ethanolamine methyltransferase and choline phosphotransferase of rat liver microsomes.
Hypothyroidism
The effect of hyper and hypothyroidism, hypophysectomy and adrenalectomy on phosphatidylethanolamine methyltransferase, phosphatidyldimethyl-ethanolamine methyltransferase and choline phosphotransferase of rat liver microsomes.
Infertility
Folate and vitamin B(12) in idiopathic male infertility.
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Insulin Resistance
Distinct infrastructure of lipid networks in visceral and subcutaneous adipose tissues in overweight humans.
From Masochistic Enzymology to Mechanistic Physiology and Disease.
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.
GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women.
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.
Phospholipid methylation in mammals: from biochemistry to physiological function.
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
Kidney Diseases
New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis.
Lipidoses
No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats.
Liver Diseases
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.
Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis.
Physiological roles of phosphatidylethanolamine N-methyltransferase.
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo.
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.
Liver Diseases, Alcoholic
ALCOHOL: its metabolism and interaction with nutrients.
Alcoholic liver injury: pathogenesis and therapy in 2001.
Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy.
Liver Failure
Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet.
Physiological consequences of disruption of mammalian phospholipid biosynthetic genes.
Liver Neoplasms
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells.
Lung Neoplasms
Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival.
Melanoma
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Neoplasm Metastasis
EMT, MET, Plasticity, and Tumor Metastasis.
Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.
Neoplasms
EMT, MET, Plasticity, and Tumor Metastasis.
Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas.
GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women.
Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats.
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells.
Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival.
Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk.
Partial EMT in Squamous Cell Carcinoma: A Snapshot.
Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor.
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.
Targeting Phospholipid Metabolism in Cancer.
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma.
Non-alcoholic Fatty Liver Disease
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
NAFLD Susceptibility Genes and their Association with Type 2 Diabetes and Obesity in a New Mexico Population.
Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis.
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease.
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.
Obesity
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
From Masochistic Enzymology to Mechanistic Physiology and Disease.
Gene-by-environment interactions of the CLOCK, PEMT, and GHRELIN loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children.
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT.
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.
Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms.
Phospholipid methylation in mammals: from biochemistry to physiological function.
Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-(PEMT) deficient mice.
Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity.
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.
Osteosarcoma
Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma.
Overnutrition
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
phosphatidylethanolamine n-methyltransferase deficiency
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Impaired Phosphatidylcholine Biosynthesis Reduces Atherosclerosis and Prevents Lipotoxic Cardiac Dysfunction in ApoE-/- Mice.
Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.
Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy.
The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice.
The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor.
Premature Birth
Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study.
Sarcoidosis
Phosphatidylethanolamine methyltransferase and cAMP, cGMP phosphodiesterases in lymphocytes and monocytes in sarcoidosis.
Spinal Dysraphism
Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida.
Stroke, Lacunar
Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific.
Urinary Bladder Neoplasms
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk.
Virus Diseases
Effect of Friend virus infection on the biosynthetic enzymes of phosphatidylcholine biosynthesis in spleen microsomes.
Vitamin B 6 Deficiency
Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes.
Whooping Cough
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin.