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Information on EC - 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

for references in articles please use BRENDA:EC2.1.1.167
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EC Tree
IUBMB Comments
Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 .
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Word Map
  • rrnas
  • nucleolar
  • 2'-o-ribose
  • pre-ribosomal
  • coimmunoprecipitation
  • methyltransferases
  • cold-sensitive
The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae
Reaction Schemes
guanosine2922 in 27S pre-rRNA
2'-O-methylguanosine2922 in 27S pre-rRNA
spb1p, more
S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA
show the reaction diagram
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