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Information on EC 2.1.1.163 - demethylmenaquinone methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.163 demethylmenaquinone methyltransferase
IUBMB Comments
The enzyme catalyses the last step in menaquinone biosynthesis. It is able to accept substrates with varying polyprenyl side chain length (the chain length is determined by polyprenyl diphosphate synthase). The enzyme from Escherichia coli also catalyses the conversion of 2-methoxy-6-octaprenyl-1,4-benzoquinone to 5-methoxy-2-methyl-3-octaprenyl-1,4-benzoquinone during the biosynthesis of ubiquinone . The enzyme probably acts on menaquinol rather than menaquinone.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
dmkt1, 2-heptaprenyl-1,4-naphthoquinone methyltransferase, dmth protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine
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