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Information on EC 2.1.1.157 - sarcosine/dimethylglycine N-methyltransferase

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IUBMB Comments
Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC 2.1.1.156, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine . The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
gsdmt, sarcosine dimethylglycine n-methyltransferase, sarcosine dimethylglycine methyltransferase, glycine sarcosine methyltransferase, dimethylglycine methyltransferase, glycine sarcosine dimethylglycine methyltransferase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine
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S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine
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S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine
show the reaction diagram
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