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Information on EC 2.1.1.139 - 3'-demethylstaurosporine O-methyltransferase

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IUBMB Comments
Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
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The enzyme appears in viruses and cellular organisms
Synonyms
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, staurosporine synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine
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