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Information on EC 2.1.1.137 - arsenite methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.137 arsenite methyltransferase
IUBMB Comments
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by EC 1.20.4.2, methylarsonate reductase, to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate for this enzyme (EC 2.1.1.137), which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
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Word Map
  • 2.1.1.137
  • dimethylarsinic
  • monomethylarsonic
  • trivalent
  • arsenic-induced
  • biomethylation
  • metalloid
  • met287thr
  • dimethylarsenate
  • dmasiii
  • arsenic-related
  • trimethylarsine
  • cyanidioschyzon
  • hplc-icpms
  • methylarsenicals
  • arsenic-contaminated
  • as-contaminated
  • arsenic-exposed
  • organoarsenical
  • n6amt1
  • methylarsonic
  • gstos
  • chromatography-inductively
  • urotsa
  • arseniciii
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
as3mt, has3mt, arsenic (+3 oxidation state) methyltransferase, cyt19, as(iii) s-adenosylmethionine methyltransferase, arsenic (iii) methyltransferase, arsenite s-adenosylmethionine methyltransferase, arsenic (+3) methyltransferase, s-adenosyl-l-methionine:arsenic(iii) methyltransferase, arsenic (+3 oxidation state)-methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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