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Information on EC 1.9.98.1 - iron-cytochrome-c reductase

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IUBMB Comments
An iron protein.
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The expected taxonomic range for this enzyme is: Acidithiobacillus ferrooxidans
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EC NUMBER
COMMENTARY hide
1.9.98.1
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RECOMMENDED NAME
GeneOntology No.
iron-cytochrome-c reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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-
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reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
ferrocytochrome-c:Fe3+ oxidoreductase
An iron protein.
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CAS REGISTRY NUMBER
COMMENTARY hide
37256-52-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ferrocytochrome c + Fe3+
ferricytochrome c + Fe2+
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ferrocytochrome c + Fe3+
ferricytochrome c + Fe2+
show the reaction diagram
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close association of enzyme with respiration chain
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome
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most highly purified fraction of the enzyme contains cytochrome c and apparently nonfunctional cytochrome b
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxo-3-phenylpropanoate
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100% inhibition at 0.08 mM
Cr2+
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slight inhibition
Cu2+
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100% inhibition at 0.1 mM
cysteine
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100% inhibition at 0.2 mM
Fe3+
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48% inhibition at 1 mM
Ni2+
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slight inhibition
p-hydroxymercuribenzoate
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100% inhibition at 0.5 mM, inhibition can be reversed by reduced glutathione or cysteine
reduced glutathione
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67% inhibition at 1 mM
additional information
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not inhibitory: atebrin, amytal, antimycin A
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0275
cytochrome c
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 6.7
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pH 5: about 50% of maximum activity, pH 6.7: about 25% of maximum activity
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.5
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several weeks, no loss of activity
22
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8 h, no loss of activity
40
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20 min, 10% loss of activity
60
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5 min, 46% loss of activity
90
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1 min, 74% loss of activity
100
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1 min, complete loss of activity
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0-5°C, several weeks without loss of activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.9.98.1)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)