Information on EC 1.8.7.3 - ferredoxin:CoB-CoM heterodisulfide reductase

for references in articles please use BRENDA:EC1.8.7.3
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The expected taxonomic range for this enzyme is: Bacteria, Archaea

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EC NUMBER
COMMENTARY hide
1.8.7.3
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RECOMMENDED NAME
GeneOntology No.
ferredoxin:CoB-CoM heterodisulfide reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = 2 reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + 2 H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
coenzyme B/coenzyme M regeneration II (ferredoxin-dependent)
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Methane metabolism
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Metabolic pathways
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
CoB,CoM:ferredoxin oxidoreductase
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
show the reaction diagram
oxidized methyl viologen + CoB + CoM
reduced methyl viologen + CoM-S-S-CoB + H+
show the reaction diagram
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
show the reaction diagram
reduced ferredoxin [iron-sulfur] cluster + DsrC-S-S-DsrC + H+
oxidized ferredoxin [iron-sulfur] cluster + DsrC + DsrC
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
show the reaction diagram
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
show the reaction diagram
reduced ferredoxin [iron-sulfur] cluster + DsrC-S-S-DsrC + H+
oxidized ferredoxin [iron-sulfur] cluster + DsrC + DsrC
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
[4Fe-4S]-center
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.1 - 1.2
CoB
1.2 - 1.4
CoM
0.05
CoM-S-S-CoB
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subunit HdrB2C2, at 21°C, pH not specified in the publication
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 18000, subunit HdrC2, SDS-PAGE; x * 33000, subunit HdrB2, SDS-PAGE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phenyl-Sepharose column chromatography, and Superdex 200 gel filtration
Q-Sepharose column chromatography and Superdex 200 gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli BL21(DE3)-pCodonPlus-RIL cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is upregulated in tetrathionate-grown cells
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LINKS TO OTHER DATABASES (specific for EC-Number 1.8.7.3)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)