Information on EC 1.8.4.3 - glutathione-CoA-glutathione transhydrogenase

for references in articles please use BRENDA:EC1.8.4.3

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EC Tree 1 Oxidoreductases 1.8 Acting on a sulfur group of donors 1.8.4 With a disulfide as acceptor 1.8.4.3 glutathione-CoA-glutathione transhydrogenase

The enzyme appears in viruses and cellular organisms

Reaction Schemes

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CoA

glutathione disulfide

CoA-glutathione

glutathione

Synonyms
glutathione coenzyme A-glutathione transhydrogenase, glutathione-coenzyme A glutathione disulfide transhydrogenase, glutathione:coenzyme A-glutathione transhydrogenase, transhydrogenase, glutathione-coenzyme A glutathione disulfide, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

glutathione coenzyme A-glutathione transhydrogenase

glutathione-coenzyme A glutathione disulfide transhydrogenase

glutathione:coenzyme A-glutathione transhydrogenase

transhydrogenase, glutathione-coenzyme A glutathione disulfide

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show all columns Go to Reaction Search

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

CoA + glutathione disulfide = CoA-glutathione + glutathione

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

redox reaction

reduction

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Go to Pathway Search

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PATHWAY SOURCE

PATHWAYS

KEGG

Cysteine and methionine metabolism, Glutathione metabolism

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Go to Systematic Name Search

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SYSTEMATIC NAME

IUBMB Comments

CoA:glutathione-disulfide oxidoreductase

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show all columns Go to CAS Registry Number Search

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CAS REGISTRY NUMBER

COMMENTARY

37256-48-7

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

CoA-glutathione + GSH

CoA + GSSG

2 entries

cysteine-glutathione + GSH

cysteine + GSSG

2 entries

pantetheine-glutathione + GSH

pantetheine + GSSG

Bos taurus

395011

Substrates: -
Products: -

thiolethanolamine-glutathione + GSH

thioethanolamine + GSSG

Bos taurus

395011

Substrates: -
Products: -

additional information

4 entries

CoA-glutathione + GSH

CoA + GSSG

Bos taurus

395011

Substrates: -
Products: -

CoA-glutathione + GSH

CoA + GSSG

Rattus norvegicus

395011, 395012

Substrates: -
Products: -

cysteine-glutathione + GSH

cysteine + GSSG

Bos taurus

395011

Substrates: -
Products: -

cysteine-glutathione + GSH

cysteine + GSSG

Rattus norvegicus

395011

Substrates: -
Products: -

additional information

Bos taurus

395011

Substrates: possible functions: 1. salvage of the coenzyme form of pantothenic acid which might be lost to the cell as CoA-glutathione, 2. maintenance of the free CoA-SH at cellular level
Products: -

additional information

Bos taurus

395011

Substrates: catalyzes GSH-GSSG exchange reaction
Products: -

additional information

Rattus norvegicus

395011

Substrates: possible functions: 1. salvage of the coenzyme form of pantothenic acid which might be lost to the cell as CoA-glutathione, 2. maintenance of the free CoA-SH at cellular level
Products: -

additional information

Rattus norvegicus

395011

Substrates: catalyzes GSH-GSSG exchange reaction
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

CoA-glutathione + GSH

CoA + GSSG

2 entries

CoA-glutathione + GSH

CoA + GSSG

Bos taurus

395011

Substrates: -
Products: -

CoA-glutathione + GSH

CoA + GSSG

Rattus norvegicus

395011

Substrates: -
Products: -

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show all columns Go to KM Value Search

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.045

CoA-glutathione

Bos taurus

395011

0.33

GSH

Bos taurus

395011

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show all columns Go to Specific Activity Search

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.513

Bos taurus

395011

12000

Rattus norvegicus

transhydrogenase of normal rat

395012

13300

Rattus norvegicus

transhydrogenase of diabetic rat

395012

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show all columns Go to pH Optimum Search

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

8.2

Bos taurus

395011

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show all columns Go to pH Range Search

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

7 - 9

Bos taurus

pH 7: about 30% of activity maximum, pH 9: about 75% of activity maximum

395011

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show all columns Go to Temperature Optimum Search

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TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

assay at

assay at

show all columns Go to Organism Search

only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

brenda

brenda

show all columns Go to Source Tissue Search

only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brenda

low activity

brenda

brenda

brenda

brenda

brenda

brenda

brenda

Highest Expressing Human Cell Lines

Filter by:

Cell Line Links

Gene Links

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show all columns Go to Molecular Weight Search

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

120000

Bos taurus

gel filtration

395011

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Go to General Stability Search

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

inactivation during storage is largely reversed by glutathione

Bos taurus

395011

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Go to Storage Stability Search

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-12°C, 6 weeks, stable

Bos taurus

395011

-12°C, 7 months, 70% loss of activity

Bos taurus

395011

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Go to Purification (commentary) Search

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

Bos taurus

395011

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

395011

Chang, S.H.; Wilken, D.R.

Participation of the unsymmetrical disulfide of coenzyme A and glutathione in an enzymatic sulfhydryl-disulfide interchange

J. Biol. Chem.

241

4251-4260

1966

Bos taurus, Rattus norvegicus

5924646

brenda

395012

Dyar, R.E.; Wilken, D.R.

Rat liver levels of coenzyme A-glutathione and of enzymes in its metabolism

Arch. Biochem. Biophys.

153

619-626

1972

Rattus norvegicus

4662104

brenda

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EXTERNAL LINKS (specific for EC-Number 1.8.4.3)

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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