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2,3-dimercaptopropanol + protein disulfide
2,3-dimercaptopropanol disulfide + protein-dithiol
2-mercaptoethanol + protein disulfide
2-mercaptoethanol disulfide + protein-dithiol
alpha-lipoate + protein disulfide
?
-
-
-
-
?
apocytochrome c + glutathione disulfide
apocytochrome c disulfide + 2 glutathione
cysteamine + protein disulfide
?
dihydrolipoamide + protein disulfide
?
-
-
-
-
?
dihydrolipoate + protein disulfide
?
dihydrolipoic acid + protein disulfide
?
dithiothreitol + protein disulfide
?
GSH + 5,5'-dithiobis(nitrobenzoic acid)
?
-
-
-
-
?
GSH + AtlS
GSSG + ?
-
-
-
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
GSH + protein disulfide
GSSG + protein-dithiol
GSH + protein-disulfide
GSSG + protein-dithiol
GSH + vasotocin
?
-
-
-
-
?
GSSG + reduced ribonuclease
GSH + oxidized ribonuclease
hydroxyethyl disulfide + protein disulfide
?
-
-
-
-
?
insulin disulfide + dithiothreitol
insulin + dithiothreitol disulfide
L-cysteine + protein disulfide
cystine + protein-dithiol
reduced dithiothreitol + NADP+
oxidized dithiothreitol + NADPH + H+
-
-
-
-
r
thioglycolic acid + protein disulfide
?
-
-
-
-
?
additional information
?
-
2,3-dimercaptopropanol + protein disulfide

2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
-
?
2,3-dimercaptopropanol + protein disulfide
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
-
?
2,3-dimercaptopropanol + protein disulfide
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
-
?
2,3-dimercaptopropanol + protein disulfide
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
-
?
2-mercaptoethanol + protein disulfide

2-mercaptoethanol disulfide + protein-dithiol
-
-
-
-
?
2-mercaptoethanol + protein disulfide
2-mercaptoethanol disulfide + protein-dithiol
-
-
-
-
?
apocytochrome c + glutathione disulfide

apocytochrome c disulfide + 2 glutathione
-
-
-
?
apocytochrome c + glutathione disulfide
apocytochrome c disulfide + 2 glutathione
-
-
-
?
cysteamine + protein disulfide

?
-
-
-
-
?
cysteamine + protein disulfide
?
-
-
-
-
?
cysteamine + protein disulfide
?
-
low activity
-
-
?
cysteamine + protein disulfide
?
-
-
-
-
?
cysteamine + protein disulfide
?
-
-
-
-
?
dihydrolipoate + protein disulfide

?
-
-
-
-
?
dihydrolipoate + protein disulfide
?
-
-
-
-
?
dihydrolipoic acid + protein disulfide

?
-
-
-
-
?
dihydrolipoic acid + protein disulfide
?
-
-
-
-
?
dihydrolipoic acid + protein disulfide
?
-
-
-
-
?
dihydrolipoic acid + protein disulfide
?
-
-
-
-
?
dithiothreitol + protein disulfide

?
-
-
-
-
?
dithiothreitol + protein disulfide
?
-
protein disulfide: insulin or thioredoxin
-
-
r
dithiothreitol + protein disulfide
?
-
-
-
-
r
dithiothreitol + protein disulfide
?
-
low activity
-
-
?
dithiothreitol + protein disulfide
?
-
-
-
-
?
GSH + insulin

GSSG + reduced insulin chain A and B
-
-
3052, 394817, 394819, 394825, 394826, 394827, 394828, 394829, 394831, 394832, 394833, 394834, 394835, 394836, 394837, 394838, 394839, 394840, 394845, 394847, 394848, 394849, 394851 -
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
-
proinsulin
-
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
-
-
-
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
-
-
-
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
-
proinsulin
-
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
-
proinsulin
-
-
?
GSH + insulin
GSSG + reduced insulin chain A and B
-
proinsulin
-
-
?
GSH + oxytoxin

?
-
-
-
-
?
GSH + oxytoxin
?
-
-
-
-
?
GSH + oxytoxin
?
-
-
-
-
?
GSH + oxytoxin
?
-
-
-
-
?
GSH + protein disulfide

GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
r
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
r
GSH + protein disulfide
GSSG + protein-dithiol
-
protein disulfide: e.g. of alcohol dehydrogenase, hexokinase, fructose-1,6-diphosphatase, malate dehydrogenase, glyceraldehyde phosphate dehydrogenase, glycerol phosphate dehydrogenase
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
prolactin is a poor substrate
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
physiological function
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
reductive degradation and assembly of proteins
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
modulation of enzymatic activity from latent to active form and vice versa
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
feedback control via insulin in the liver
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
protein disulfide: thioredoxin
-
-
r
GSH + protein disulfide
GSSG + protein-dithiol
-
very rapid disulfide interchange reaction
-
-
r
GSH + protein disulfide
GSSG + protein-dithiol
-
protein disulfide: enzyme itself
-
r
GSH + protein disulfide
GSSG + protein-dithiol
-
disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds
-
-
r
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
physiological function
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
reductive degradation and assembly of proteins
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
modulation of enzymatic activity from latent to active form and vice versa
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
feedback control via insulin in the liver
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
physiological function
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
reductive degradation and assembly of proteins
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
modulation of enzymatic activity from latent to active form and vice versa
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
major contributor to the inactivation of oxytoxin by lactating mammary gland
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
feedback control via insulin in the liver
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
synthesis of protein disulfide bond
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
enzyme plays a role in formation of intramonomer bonds common to all immunoglobulin molecules
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
physiological function
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
reductive degradation and assembly of proteins
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
modulation of enzymatic activity from latent to active form and vice versa
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
enzyme not directly involved in the subcellular processing of receptor-bound internalized insulin
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
feedback control via insulin in the liver
-
-
?
GSH + protein disulfide
GSSG + protein-dithiol
-
initial step in sequential insulin degradation
-
-
?
GSH + protein-disulfide

GSSG + protein-dithiol
-
-
-
-
?
GSH + protein-disulfide
GSSG + protein-dithiol
-
-
-
-
?
GSH + vasopressin

?
-
-
-
-
?
GSH + vasopressin
?
-
-
-
-
?
GSH + vasopressin
?
-
-
-
-
?
GSH + vasopressin
?
-
-
-
-
?
GSSG + reduced ribonuclease

GSH + oxidized ribonuclease
-
-
-
-
?
GSSG + reduced ribonuclease
GSH + oxidized ribonuclease
-
-
-
r
insulin disulfide + dithiothreitol

insulin + dithiothreitol disulfide
-
-
-
-
?
insulin disulfide + dithiothreitol
insulin + dithiothreitol disulfide
-
-
-
?
L-cysteine + protein disulfide

cystine + protein-dithiol
-
-
-
-
?
L-cysteine + protein disulfide
cystine + protein-dithiol
-
-
-
-
?
additional information

?
-
-
bdbC and bdbD catalyze the formation of disulfide bonds that are essential for the DNA binding and uptake machinery
-
-
?
additional information
?
-
-
bdbC and bdbD catalyze the formation of disulfide bonds that are essential for the DNA binding and uptake machinery
-
-
?
additional information
?
-
-
ResA, probably together with another thiol-disulfide oxidoreductase, CcdA, is required for the the reduction of the cysteinyls in the heme binding site of apocytochrome c
-
-
?
additional information
?
-
-
StoA is a thiol-disulfide oxidoreductase that is involved in breaking disulfide bonds in cortex components or in proteins important for cortex synthesis
-
-
?
additional information
?
-
-
reduction of choleragen
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species
-
-
?
additional information
?
-
-
glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species
-
-
?
additional information
?
-
-
glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
scrambled trypsin inhibitor and proinsulin
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
reduction of ricin and other plant thiols
-
-
?
additional information
?
-
-
the enzyme is unable to reduce insulin
-
-
?
additional information
?
-
-
redox reaction between different Dsn proteins
-
-
?
additional information
?
-
-
DsbB protein re-oxidizes the reduced DsbA protein
-
-
?
additional information
?
-
-
DsbB protein re-oxidizes the reduced DsbA protein
-
-
?
additional information
?
-
-
the enzyme is required for efficient disulfide bond formation in the periplasm
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
scrambled trypsin inhibitor and proinsulin
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
multifunctional enzyme that efficiently catalyzes disulfide reduction, disulfide isomerization, and dithiol oxidation
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
immunoglobulin IgM and IgG
-
-
?
additional information
?
-
-
glutathione-insulin transhydrogenase EC 1.8.4.2 and protein disulfide-isomerase EC 5.3.4.1 activities are not both catalyzed by a single enzyme species
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
scrambled lysozyme
-
-
?
additional information
?
-
-
scrambled trypsin inhibitor and proinsulin
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
-
-
?
additional information
?
-
-
reduction of ricin and other plant thiols
-
-
?
additional information
?
-
-
addition of GSH-dependent protein disulfide oxidoreductase to flour significantly increases dough extensibility (from 17 to 49% for cultivars with different quality), which implies the ability of the enzyme to disrupt disulfide bonds in high-molecular-weight gluten polymers
-
-
?
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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