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The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
selenbp1, selenium-binding protein 1, selenium binding protein 1, methanethiol oxidase, sbp56, more
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methyl mercaptan oxidase
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methylmercaptan oxidase
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oxidase, methyl mercaptan
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selenium binding protein 1
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selenium-binding protein 1
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MTO
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methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2
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MetaCyc
dimethyl sulfide degradation I
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methanethiol:oxygen oxidoreductase
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ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
sulfide + O2
sulfur + H2O2
ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
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ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
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ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
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ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: enzyme can be induced by methylmercaptan
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: enzyme in oxidation pathway of dimethyl disulfide
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: enzyme in oxidation pathway of dimethyl disulfide
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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sulfide + O2
sulfur + H2O2
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Substrates: -
Products: -
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sulfide + O2
sulfur + H2O2
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Substrates: -
Products: -
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sulfide + O2
sulfur + H2O2
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Substrates: no activity
Products: -
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sulfide + O2
sulfur + H2O2
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Substrates: no activity
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: enzyme can be induced by methylmercaptan
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: enzyme in oxidation pathway of dimethyl disulfide
Products: -
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methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
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Substrates: enzyme in oxidation pathway of dimethyl disulfide
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
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Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
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Substrates: -
Products: -
?
methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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methanethiol + O2 + H2O
formaldehyde + hydrogen sulfide + H2O2
Substrates: -
Products: -
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Cu2+
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metalloenzyme that requires Cu2+ for enzyme activity. Cu2+ is involved in the redox process of methanethiol oxidation
Cu2+
metalloenzyme that requires Cu2+ for enzyme activity. Cu2+ is involved in the redox process of methanethiol oxidation
Cu2+
metalloenzyme that requires Cu2+ for enzyme activity. Cu2+ is involved in the redox process of methanethiol oxidation
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K2SO4
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inhibition at concentration below 200 mM, original activity is recovered at 200 mM
NaCl
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inhibition at concentration below 200 mM, original activity is recovered at 200 mM
cyanide
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ethyl mercaptan
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methanethiol
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above 0.014 mM
Sulfide
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non-competitive inhibition of methyl mercaptan oxidation
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0.018
ethyl mercaptan
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0.0048 - 0.0313
methanethiol
0.0048
methanethiol
pH and temperature not specified in the publication
0.005 - 0.01
methanethiol
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0.008 - 0.042
methanethiol
0.008
methanethiol
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additional information
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SwissProt
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UniProt
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UniProt
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SwissProt
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E6
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E6
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methanethiol oxidase activity is strongly enhanced in Caco-2 cells upon enterocyte differentiation, in parallel with increased SELENBP1 levels
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Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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malfunction
an inborn error of metabolism caused by methanethiol oxidase-deficiency leads to a malodor syndrome
physiological function
mature enterocytes located at the tip of colonic crypts are capable of eliminating microbiome-derived methanethiol
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180000 - 200000
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native gel electrophoresis
40000
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1 * 40000, SDS-PAGE
40000 - 50000
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gel filtration
46186
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electrospray-ionisation mass spectroscopy
49000
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1 * 49000, SDS-PAGE
64500
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x * 64500, SDS-PAGE
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homotetramer
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4 * 46000, SDS-PAGE
monomer
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1 * 49000, SDS-PAGE
monomer
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1 * 49000, SDS-PAGE
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monomer
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1 * 40000, SDS-PAGE
monomer
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1 * 40000, SDS-PAGE
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G225W
the mutant is identified in individuals with extraoral halitosis. Inactive mutant enzyme
H329Y
the mutant is identified in individuals with extraoral halitosis. Inactive mutant enzyme
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65
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10 min, complete loss of activity
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-20°C, stable for months
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methanethiol oxidase activity is strongly enhanced in Caco-2 cells upon enterocyte differentiation, in parallel with increased SELENBP1 levels
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Suylen, G.M.H.; Large, P.J.; van Dijken, J.P.; Kuenen, J.G.
Methyl mercaptan oxidase, a key enzyme in the metabolism of methylated sulphur compounds by Hyphomicrobium EG
J. Gen. Microbiol.
133
2989-2997
1987
Hyphomicrobium sp., Hyphomicrobium sp. EG
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Gould, W.D.; Kanagawa, T.
Purification and properties of methyl mercaptan oxidase from Thiobacillus thioparus TK-m
J. Gen. Microbiol.
138
217-221
1992
Thiobacillus thioparus, Thiobacillus thioparus TK-m
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brenda
Smith, N.A.; Kelly, D.P.
Mechanism of oxidation of dimethyl disulphide by Thiobacillus thioparus
J. Gen. Microbiol.
134
3031-3039
1988
Thiobacillus thioparus, Thiobacillus thioparus E6
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brenda
Kim, S.J.; Shin, H.J.; Kim, Y.C.; Yang, J.W.
Isolation and purification of methyl mercaptan oxidase from Rhodococcus rhodochrous for mercaptan detection
Biotechnol. Bioprocess Eng.
5
465-468
2000
Rhodococcus rhodochrous
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Eyice, O.e.; Myronova, N.; Pol, A.; Carrion, O.; Todd, J.D.; Smith, T.J.; Gurman, S.J.; Cuthbertson, A.; Mazard, S.; Mennink-Kersten, M.A.; Bugg, T.D.; Andersson, K.K.; Johnston, A.W.; Op den Camp, H.J.; Schaefer, H.
Bacterial SBP56 identified as a Cu-dependent methanethiol oxidase widely distributed in the biosphere
ISME J.
12
145-160
2018
Hyphomicrobium sp. VS, Methylophaga thiooxydans (C0N434), Methylophaga thiooxydans DMS010 (C0N434), Ruegeria pomeroyi (Q5LKW0), Ruegeria pomeroyi
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Pol, A.; Renkema, G.H.; Tangerman, A.; Winkel, E.G.; Engelke, U.F.; de Brouwer, A.P.M.; Lloyd, K.C.; Araiza, R.S.; van den Heuvel, L.; Omran, H.; Olbrich, H.; Oude Elberink, M.; Gilissen, C.; Rodenburg, R.J.; Sass, J.O.; Schwab, K.O.; Schaefer, H.; Venselaar, H.; Sequeira, J.S.; Op den Camp, H.J.M.; Wevers, R.A.
Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis
Nat. Genet.
50
120-129
2018
Homo sapiens (Q13228), Homo sapiens
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Philipp, T.M.; Will, A.; Richter, H.; Winterhalter, P.R.; Pohnert, G.; Steinbrenner, H.; Klotz, L.O.
A coupled enzyme assay for detection of selenium-binding protein 1 (SELENBP1) methanethiol oxidase (MTO) activity in mature enterocytes
Redox Biol.
43
101972
2021
Homo sapiens (Q13228), Homo sapiens
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